BacMap

Definition	Bacillus licheniformis ATCC 14580, complete genome.
Accession	NC_006322
Length	4,222,645

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The map label for this gene is fabG [H]

Identifier: 52786809

GI number: 52786809

Start: 2967933

End: 2968694

Strand: Reverse

Name: fabG [H]

Synonym: BLi03081

Alternate gene names: 52786809

Gene position: 2968694-2967933 (Counterclockwise)

Preceding gene: 52786810

Following gene: 52786808

Centisome position: 70.3

GC content: 50.13

Gene sequence:

>762_bases
GTGCGCCATGCGTTAATTACTGCCGGTTCAAAAGGTTTGGGGCGTAAAGTGACGGAAGCCCTGCTTGAAAAAGGCTACTC
AGTGACGGTGAATTACAGGCAAGACGAAGAAGCTGTCCGCCGCCTCAAAGAAAAATGGCGGTCATCCCTTGACCGTTTGC
AGTTTGTTAAGGGTGATGTCACCAGGAAAGAAGACCTGCTCCGGATGGTGAATGCCGCTCTTGAGCGATTTGGAAAAATT
GATCTTCTGATCAATAATGCCGGCCCATACATATTTGAACGAAAAAAGCTTGCGGATTATACTGATGATGAATGGTATGA
CATGCTTGAAGGCAACTTAAGCTCTGTCTTCCATCTGTTTAAAGCGGTTGTTCCGATCATGAGGCGCCAGCGGTTCGGCC
GAATCATCACTTACGGATTTCAGGGGGCCGACCATGCGCCTGGCTGGCTGCATCGTTCCGCTTTTGGAGCGGCAAAAGTA
GGGCTGGCTTCTTTAACAAAGACGATCGCCATTGAAGAAGCGGGCTCCGGCATCACAGCCAACATGGTCTGTCCAGGCAA
CATTGTCGGGGATATGAAAGAGGCCTCGATTTCAGAAGCGAGGGCGTCACTTGATGAGGAAACGCCGATCGGCAGGTCGG
GAACCGGTGAAGACATCGCAAGGATCATCACTTTTCTATGCGATGAACATTCCGACTACATTACGGGAACAGTCATTGAA
GCCACAGGCGGCTTGAATGTGATTAACCGTCATTCTCTCTAG

Upstream 100 bases:

>100_bases
ATGCTCCAAATGTGATATCCTAAGGGTTTTGTAGTAAAGTATAGGTAGATTAATGCAATCATTTGCGAATACCGAGAACC
AATGCCTGGGAGGGAAAGAT

Downstream 100 bases:

>100_bases
ACGTGCGAAATTAAAAAAATCAGGGGTGGATATGATGAAAGTGGCATATCATGGTCATTCAGTGGTAACAGTTGATACGG
GAGATCATCAGTTGATCTTC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRHALITAGSKGLGRKVTEALLEKGYSVTVNYRQDEEAVRRLKEKWRSSLDRLQFVKGDVTRKEDLLRMVNAALERFGKI
DLLINNAGPYIFERKKLADYTDDEWYDMLEGNLSSVFHLFKAVVPIMRRQRFGRIITYGFQGADHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAGSGITANMVCPGNIVGDMKEASISEARASLDEETPIGRSGTGEDIARIITFLCDEHSDYITGTVIE
ATGGLNVINRHSL

Sequences:

>Translated_253_residues
MRHALITAGSKGLGRKVTEALLEKGYSVTVNYRQDEEAVRRLKEKWRSSLDRLQFVKGDVTRKEDLLRMVNAALERFGKI
DLLINNAGPYIFERKKLADYTDDEWYDMLEGNLSSVFHLFKAVVPIMRRQRFGRIITYGFQGADHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAGSGITANMVCPGNIVGDMKEASISEARASLDEETPIGRSGTGEDIARIITFLCDEHSDYITGTVIE
ATGGLNVINRHSL
>Mature_253_residues
MRHALITAGSKGLGRKVTEALLEKGYSVTVNYRQDEEAVRRLKEKWRSSLDRLQFVKGDVTRKEDLLRMVNAALERFGKI
DLLINNAGPYIFERKKLADYTDDEWYDMLEGNLSSVFHLFKAVVPIMRRQRFGRIITYGFQGADHAPGWLHRSAFGAAKV
GLASLTKTIAIEEAGSGITANMVCPGNIVGDMKEASISEARASLDEETPIGRSGTGEDIARIITFLCDEHSDYITGTVIE
ATGGLNVINRHSL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=28.5171102661597, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=32.5490196078431, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI59889578, Length=217, Percent_Identity=27.1889400921659, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=29.3650793650794, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI66933014, Length=192, Percent_Identity=29.1666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=27.2357723577236, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=29.5081967213115, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=30.1960784313725, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4504505, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=25, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=35.5102040816327, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=28.3400809716599, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=28, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=26.5060240963855, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=27.9352226720648, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=25.7028112449799, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=25.9109311740891, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=26.8774703557312, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=25.6916996047431, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=24, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=25.4901960784314, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=25.4166666666667, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=29.6442687747036, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=32.046332046332, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=32.6996197718631, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=31.0606060606061, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=29.1187739463602, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=30.6818181818182, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=29.5454545454545, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=28.968253968254, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=274, Percent_Identity=29.1970802919708, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=25.5813953488372, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=26.4227642276423, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=27.7153558052434, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=30.188679245283, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=26.8199233716475, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=28.3018867924528, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=28.1368821292776, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=28.0769230769231, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=26.1538461538462, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=27.3408239700375, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=24.7104247104247, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=25.1908396946565, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=256, Percent_Identity=25.78125, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=26.9035532994924, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=25.8964143426295, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=193, Percent_Identity=29.5336787564767, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=179, Percent_Identity=27.9329608938547, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24644339, Length=262, Percent_Identity=27.4809160305344, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=28.8, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=29.0076335877863, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28571526, Length=269, Percent_Identity=25.2788104089219, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=24.5283018867925, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859837, Length=251, Percent_Identity=26.6932270916335, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28049; Mature: 28049

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHALITAGSKGLGRKVTEALLEKGYSVTVNYRQDEEAVRRLKEKWRSSLDRLQFVKGDV
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TRKEDLLRMVNAALERFGKIDLLINNAGPYIFERKKLADYTDDEWYDMLEGNLSSVFHLF
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHCCHHHHHHHH
KAVVPIMRRQRFGRIITYGFQGADHAPGWLHRSAFGAAKVGLASLTKTIAIEEAGSGITA
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
NMVCPGNIVGDMKEASISEARASLDEETPIGRSGTGEDIARIITFLCDEHSDYITGTVIE
EEECCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
ATGGLNVINRHSL
ECCCCCCCCCCCC
>Mature Secondary Structure
MRHALITAGSKGLGRKVTEALLEKGYSVTVNYRQDEEAVRRLKEKWRSSLDRLQFVKGDV
CCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
TRKEDLLRMVNAALERFGKIDLLINNAGPYIFERKKLADYTDDEWYDMLEGNLSSVFHLF
CHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHCCHHHHHHHH
KAVVPIMRRQRFGRIITYGFQGADHAPGWLHRSAFGAAKVGLASLTKTIAIEEAGSGITA
HHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
NMVCPGNIVGDMKEASISEARASLDEETPIGRSGTGEDIARIITFLCDEHSDYITGTVIE
EEECCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
ATGGLNVINRHSL
ECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]