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The map label for this gene is msrA

Identifier: 52786047

GI number: 52786047

Start: 2257024

End: 2257569

Strand: Reverse

Name: msrA

Synonym: BLi02303

Alternate gene names: 52786047

Gene position: 2257569-2257024 (Counterclockwise)

Preceding gene: 52786050

Following gene: 52786046

Centisome position: 53.46

GC content: 49.45

Gene sequence:

>546_bases
ATGGCTGAAAAACGCGAACTCGCCACATTTGCCGGAGGCTGCTTTTGGTGTATGGTCAAGCCTTTTGACGAACAGCCGGG
CATTCTAAAAGTCGAATCCGGCTATACCGGCGGCCATACGGAAAATCCGACCTATGAAGAGGTGTGCAGCAATACAACGG
GACATAGGGAAGCGGTGCAAATCACATTTGATCCCGATGTCTTTCCATACGAAAAACTGCTGGAACTCTACTGGCAGCAA
ATCGATCCCACTGACAGCGGAGGACAATTCACAGACCGCGGAGAGTCTTACCGGACAGCGATTTTTTACCATAATGACAA
GCAGCGGAAACTCGCTGAAGAATCGAAGAAAAAGCTCGGAGAAAGCGGCATCTTTAAAGATCCAATCGCGACCGACATTC
TGGAGGCCGGGCCATTTTATCCGGCTGAGGAGTATCACCAGGACTATCATAAAAAGCACCCTGAACGCTACACACAGTAT
CGGATCGGAAGCGGAAGGGAAGGATTTTTACAACAGCATTGGGGGCGAAAGCATGACGAACAATAA

Upstream 100 bases:

>100_bases
GTGTTAAAAGTTGTTTCCTGTGAGCGGGAGCGGGCTTAAAAATGAGCATGCTGTGATATAATGGTTCCCAACAAGTGTTG
AAGAGAAGGAGGCAGAACAG

Downstream 100 bases:

>100_bases
AGAAGAACGGCTGAAACAGCTGACCCGGATGCAATATGAAGTAACGCAGAAAAACGGGACGGAGCCTCCATTCCAAAACG
AGTACTGGGACCTGCATGAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MAEKRELATFAGGCFWCMVKPFDEQPGILKVESGYTGGHTENPTYEEVCSNTTGHREAVQITFDPDVFPYEKLLELYWQQ
IDPTDSGGQFTDRGESYRTAIFYHNDKQRKLAEESKKKLGESGIFKDPIATDILEAGPFYPAEEYHQDYHKKHPERYTQY
RIGSGREGFLQQHWGRKHDEQ

Sequences:

>Translated_181_residues
MAEKRELATFAGGCFWCMVKPFDEQPGILKVESGYTGGHTENPTYEEVCSNTTGHREAVQITFDPDVFPYEKLLELYWQQ
IDPTDSGGQFTDRGESYRTAIFYHNDKQRKLAEESKKKLGESGIFKDPIATDILEAGPFYPAEEYHQDYHKKHPERYTQY
RIGSGREGFLQQHWGRKHDEQ
>Mature_180_residues
AEKRELATFAGGCFWCMVKPFDEQPGILKVESGYTGGHTENPTYEEVCSNTTGHREAVQITFDPDVFPYEKLLELYWQQI
DPTDSGGQFTDRGESYRTAIFYHNDKQRKLAEESKKKLGESGIFKDPIATDILEAGPFYPAEEYHQDYHKKHPERYTQYR
IGSGREGFLQQHWGRKHDEQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=42.1383647798742, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=42.1383647798742, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=42.2018348623853, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.078947368421, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=37.4149659863946, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=32.3353293413174, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=34.5070422535211, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=33.1034482758621, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=33.5766423357664, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_BACLD (Q65ID1)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_079465.2
- RefSeq:   YP_091876.1
- HSSP:   P0A744
- ProteinModelPortal:   Q65ID1
- SMR:   Q65ID1
- STRING:   Q65ID1
- EnsemblBacteria:   EBBACT00000056382
- EnsemblBacteria:   EBBACT00000062287
- GeneID:   3028308
- GeneID:   3101335
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02303
- KEGG:   bli:BL01421
- NMPDR:   fig|279010.5.peg.154
- eggNOG:   COG0225
- GeneTree:   EBGT00050000000580
- HOGENOM:   HBG748152
- ProtClustDB:   PRK14054
- BioCyc:   BLIC279010-1:BLI02303-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 21007; Mature: 20876

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: ACT_SITE 14-14

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKRELATFAGGCFWCMVKPFDEQPGILKVESGYTGGHTENPTYEEVCSNTTGHREAVQ
CCCHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEE
ITFDPDVFPYEKLLELYWQQIDPTDSGGQFTDRGESYRTAIFYHNDKQRKLAEESKKKLG
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHC
ESGIFKDPIATDILEAGPFYPAEEYHQDYHKKHPERYTQYRIGSGREGFLQQHWGRKHDE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHCCCCCCC
Q
C
>Mature Secondary Structure 
AEKRELATFAGGCFWCMVKPFDEQPGILKVESGYTGGHTENPTYEEVCSNTTGHREAVQ
CCHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEE
ITFDPDVFPYEKLLELYWQQIDPTDSGGQFTDRGESYRTAIFYHNDKQRKLAEESKKKLG
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHC
ESGIFKDPIATDILEAGPFYPAEEYHQDYHKKHPERYTQYRIGSGREGFLQQHWGRKHDE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHCCCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA