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The map label for this gene is yodQ [H]

Identifier: 52786040

GI number: 52786040

Start: 2249997

End: 2251265

Strand: Reverse

Name: yodQ [H]

Synonym: BLi02296

Alternate gene names: 52786040

Gene position: 2251265-2249997 (Counterclockwise)

Preceding gene: 52786041

Following gene: 52786039

Centisome position: 53.31

GC content: 50.59

Gene sequence:

>1269_bases
ATGGAGAACATAGAGAGAAAAGTGTGCGATTGGATCGATTCGCATGAGCAAAAAGCGATTCGCCTTTTGAAAAAACTCGT
CGGAGAAAAAAGCACGATGGGCCGAGAATTTAACGCCCAGGCCGTCGTCCTGGAGAAATTGAGGCAATTCGAAGCTGAAA
TCGATGTCTGGGAGCCAAGCATAAAGCAGTTGGAACAGCATCCGCTGTTTAAATCAGACAGAACAAGCTTTAAAGAAAGC
CCGAATATTGCGGCTGTTAAAAAAGGAAAGGGCGGCGGGAAATCGCTGATCTTAAACGGACACATCGATGTCGTGCCTGA
AGGAAACAGAAAAGACTGGGAGACGGAGCCTTTTCAGCCGGTTGTGAAGCAGGGGCGGATATACGGCCGAGGCACAACTG
ACATGAAAGGCGGCAATACCGCTCTTTTAATCGCGATGGAAGCGCTGGAGCAATGCGGGGTTCAACTAAAAGGAGACCTT
ATTTTTCAAAGTGTCGTAGACGAGGAGTGTGGCGGAGCCGGGACGCTTGCGGCCGTAATGAGGGGCTACAAAGCGGACGG
CGCTTTGATTCCCGAGCCGACAAATATGAAAATGTTTATTAAACAGCAGGGCTCAATGTGGTTCAGAATCACGGTCAAAG
GGCTTTCTGCGCACGGCGGCACAAGATATGAAGGCGTCAGCGCCATCGAAAAAAGCATGCTTGTCATTCAATCGCTCCGC
CAGCTTGAACAGGTCAGGAATAAGAGAATAACAGATTCTTTGTATGACAATATCCCGATTCCGGTCCCGATCAACATCGG
CACGATCAACGGAGGCGCCTGGCCTTCGTCGGTTGCCGACACGGTGACACTGGAAGGAAGGTGCGGAATCGCTCCGAACG
AATCCCCTGAAGCCGTCCAGTCCGAGCTTGAAAACTGGCTCAACGATCTTCAGTACCATGATGAATGGTTTAAGCACTAT
CCTGTTGATATAGAATGGTTCGGCGCCATGTGGCTTCCTAACGATTTGGCTGAAGACCATGAACTGACGAAAGTGCTGAA
ATCCGCCTATCAAACCATCACGGCAGAGGCTCCGCTCATCGAAGCTTCCCCGTGGGCGACAGACGGCGGAATATTGTCGC
ACGCCGGAGGCACCCCTGTCATCGTCTTCGGGCCGGGAGAAACGAAAATGGCCCACCAGGCAAACGAATACATTGAAAAA
GACGCCCTGATCCAGTCAGCCAAGATCATCAGCCTGTTTATTATGAATTGGTGTGATTATGAAAGGTGA

Upstream 100 bases:

>100_bases
TTACAAGAGCTGATGAATGAAGAGGATCTTGATGATGTGCTGCGGCTGACGGAGGGAAAGATCCGGATCGACGGGCCGCT
TTCGTAAGAGGAGGAATTGG

Downstream 100 bases:

>100_bases
AAAGATCAGCCGTTTCGGAGGTTAAATCATGGTGAAAAAATGGAGCAATGACAGCTGCACGCTTGAAGCGGATGTCGACT
TGTTCAGCAAAAGGATCAGA

Product: acetylornithine deacetylase

Products: acetate; L-ornithine

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MENIERKVCDWIDSHEQKAIRLLKKLVGEKSTMGREFNAQAVVLEKLRQFEAEIDVWEPSIKQLEQHPLFKSDRTSFKES
PNIAAVKKGKGGGKSLILNGHIDVVPEGNRKDWETEPFQPVVKQGRIYGRGTTDMKGGNTALLIAMEALEQCGVQLKGDL
IFQSVVDEECGGAGTLAAVMRGYKADGALIPEPTNMKMFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMLVIQSLR
QLEQVRNKRITDSLYDNIPIPVPINIGTINGGAWPSSVADTVTLEGRCGIAPNESPEAVQSELENWLNDLQYHDEWFKHY
PVDIEWFGAMWLPNDLAEDHELTKVLKSAYQTITAEAPLIEASPWATDGGILSHAGGTPVIVFGPGETKMAHQANEYIEK
DALIQSAKIISLFIMNWCDYER

Sequences:

>Translated_422_residues
MENIERKVCDWIDSHEQKAIRLLKKLVGEKSTMGREFNAQAVVLEKLRQFEAEIDVWEPSIKQLEQHPLFKSDRTSFKES
PNIAAVKKGKGGGKSLILNGHIDVVPEGNRKDWETEPFQPVVKQGRIYGRGTTDMKGGNTALLIAMEALEQCGVQLKGDL
IFQSVVDEECGGAGTLAAVMRGYKADGALIPEPTNMKMFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMLVIQSLR
QLEQVRNKRITDSLYDNIPIPVPINIGTINGGAWPSSVADTVTLEGRCGIAPNESPEAVQSELENWLNDLQYHDEWFKHY
PVDIEWFGAMWLPNDLAEDHELTKVLKSAYQTITAEAPLIEASPWATDGGILSHAGGTPVIVFGPGETKMAHQANEYIEK
DALIQSAKIISLFIMNWCDYER
>Mature_422_residues
MENIERKVCDWIDSHEQKAIRLLKKLVGEKSTMGREFNAQAVVLEKLRQFEAEIDVWEPSIKQLEQHPLFKSDRTSFKES
PNIAAVKKGKGGGKSLILNGHIDVVPEGNRKDWETEPFQPVVKQGRIYGRGTTDMKGGNTALLIAMEALEQCGVQLKGDL
IFQSVVDEECGGAGTLAAVMRGYKADGALIPEPTNMKMFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMLVIQSLR
QLEQVRNKRITDSLYDNIPIPVPINIGTINGGAWPSSVADTVTLEGRCGIAPNESPEAVQSELENWLNDLQYHDEWFKHY
PVDIEWFGAMWLPNDLAEDHELTKVLKSAYQTITAEAPLIEASPWATDGGILSHAGGTPVIVFGPGETKMAHQANEYIEK
DALIQSAKIISLFIMNWCDYER

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=342, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790395, Length=352, Percent_Identity=27.2727272727273, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789236, Length=337, Percent_Identity=26.7062314540059, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788816, Length=234, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24649206, Length=346, Percent_Identity=25.1445086705202, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356353, Length=343, Percent_Identity=23.9067055393586, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24649210, Length=343, Percent_Identity=23.9067055393586, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24649208, Length=343, Percent_Identity=23.0320699708455, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24649202, Length=343, Percent_Identity=22.7405247813411, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24649204, Length=343, Percent_Identity=22.7405247813411, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16

Molecular weight: Translated: 46937; Mature: 46937

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIERKVCDWIDSHEQKAIRLLKKLVGEKSTMGREFNAQAVVLEKLRQFEAEIDVWEPS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
IKQLEQHPLFKSDRTSFKESPNIAAVKKGKGGGKSLILNGHIDVVPEGNRKDWETEPFQP
HHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCEEEEECCEEEEECCCCCCCCCCCCHH
VVKQGRIYGRGTTDMKGGNTALLIAMEALEQCGVQLKGDLIFQSVVDEECGGAGTLAAVM
HHHCCEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCHHHHHHH
RGYKADGALIPEPTNMKMFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMLVIQSLR
CCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
QLEQVRNKRITDSLYDNIPIPVPINIGTINGGAWPSSVADTVTLEGRCGIAPNESPEAVQ
HHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHHH
SELENWLNDLQYHDEWFKHYPVDIEWFGAMWLPNDLAEDHELTKVLKSAYQTITAEAPLI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHCCCCEE
EASPWATDGGILSHAGGTPVIVFGPGETKMAHQANEYIEKDALIQSAKIISLFIMNWCDY
ECCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ER
CC
>Mature Secondary Structure
MENIERKVCDWIDSHEQKAIRLLKKLVGEKSTMGREFNAQAVVLEKLRQFEAEIDVWEPS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
IKQLEQHPLFKSDRTSFKESPNIAAVKKGKGGGKSLILNGHIDVVPEGNRKDWETEPFQP
HHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCCCEEEEECCEEEEECCCCCCCCCCCCHH
VVKQGRIYGRGTTDMKGGNTALLIAMEALEQCGVQLKGDLIFQSVVDEECGGAGTLAAVM
HHHCCEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCHHHHHHH
RGYKADGALIPEPTNMKMFIKQQGSMWFRITVKGLSAHGGTRYEGVSAIEKSMLVIQSLR
CCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
QLEQVRNKRITDSLYDNIPIPVPINIGTINGGAWPSSVADTVTLEGRCGIAPNESPEAVQ
HHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHHH
SELENWLNDLQYHDEWFKHYPVDIEWFGAMWLPNDLAEDHELTKVLKSAYQTITAEAPLI
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHCCCCEE
EASPWATDGGILSHAGGTPVIVFGPGETKMAHQANEYIEKDALIQSAKIISLFIMNWCDY
ECCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ER
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-acetyl-L-ornithine; H2O

Specific reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]