Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 52785790

GI number: 52785790

Start: 1978996

End: 1980999

Strand: Direct

Name: tkt [H]

Synonym: BLi02036

Alternate gene names: 52785790

Gene position: 1978996-1980999 (Clockwise)

Preceding gene: 52785789

Following gene: 52785791

Centisome position: 46.87

GC content: 49.25

Gene sequence:

>2004_bases
ATGAAAACGATTGAATTAAAATCTGTCGCAACAATACGAACACTCTCCATAGACGCGATTGAAAAAGCTAAATCCGGTCA
CCCCGGCATGCCGATGGGGACTGCTCCGATGGCTTATGCGCTTTGGACAAAAATGATGAATGTCAGCCCTGAAAATCCGA
ATTGGTTTAACAGGGACCGTTTTGTGCTTTCCGCCGGACACGGATCAATGCTTTTGTACAGCATGCTTCACTTAAGCGGA
TATGACGTTTCAATTGAAGACCTCAAAAATTTCCGCCAATGGGGAAGCAAAACTCCTGGGCATCCGGAATTCGGACATAC
TCCGGGTGTAGATGCGACTACAGGTCCGCTTGGCCAAGGAATCGGAATGGCTGTCGGAATGGCGCTTGCTGAACGTCACC
TTGCTGAAACTTACAACCGTGACGACTATCGCGTCGTTGACCATTATACATACAGCATTTGCGGTGACGGAGACTTGATG
GAGGGAATTTCATCCGAAGCGGCTTCGCTTGCGGGACATTTGAACCTCGGCCGTCTCATCGTGCTTTATGATTCAAATGA
CATTTCGCTTGACGGCGAACTAAACCGCTCATTCTCTGAAAATGTAAAGCAGCGCTTTGAAGCGATGAATTGGGAAGTGC
TTTATGTTGAAGACGGCAACAACATTGCCGAAATTACGGCGGCCATCGAGAAAGCGAAACAAAATGAAAAGCAGCCGACA
TTAATTGAAGTGAAAACAACGATCGGTTTCGGTTCTCCAAACCGTGCGGGCACATCCGGCGTCCACGGCGCTCCGCTCGG
ATCAGAAGAGGCGAAATTAACGAAGGAAGCGTATGAGTGGACATACGAAGAAGATTTTTATGTTCCTTCCGAAGTGTACG
AGCACTTTAACGAAACAGTGAAGGAAGCGGGCAAGAAAAAAGAGGCGGAATGGAACGAACTGTTCTCCGCATACAAGAAA
GCCCACCCGGAACTTGCCGAAGAGCTTGAACTGGCGATCAAAGGCGAGCTTCCTGAAGGATGGGATCAGAAAGTACCTGT
ATATGAAAAAGGAAGCAGCCTTGCTTCACGTGCATCCTCAGGTGAAGTGTTAAACGGAATCGCTCAACAAGTGCCGTTTT
TCTTTGGCGGATCCGCGGACTTGGCCGGTTCCAACAAAACGACAATCAAAAACGGCGGAGATGTTTCAGCGAAGGATTAC
GCCGGCAGAAATATCTGGTTCGGTGTAAGGGAATTTGCGATGGGAGCAGCTTTGAACGGAATGGCTCTTCACGGAGGCCT
CCGCGTATTCGGCGGAACGTTCTTCGTTTTCTCCGATTACTTGAGACCAGCGATTCGTCTTGCTGCATTGATGGGGCTTC
CTGTCACCTATGTATTTACACATGACAGCATTGCCGTCGGTGAAGACGGACCGACTCATGAGCCGATTGAACAGCTGGCA
TCACTTCGTGCGCTGCCGAACTTGTCCGTCATCAGACCTGCCGACGGAAATGAAACAGCAGCTGCCTGGAAGCTCGCGCT
TCAATCAAAAGACCAGCCGACTGCGCTTGTGTTGACACGCCAAAACTTGCCGACAATCGATCAGTCTGCTGAAACGGCTT
ATGAAGGCGTTAAAAAGGGTGCATATGTCGTTTCAAAAAGCCAAAACGAAAAACCGGAAGCGATCTTGCTTGCGAGCGGA
TCTGAAGTTGGCCTTGCGCTTGATGCACAAAGCGAGCTGCAAAAAGAAGGCATTGACGTATCCGTTGTCAGCGTTCCGTC
ATGGGATCGATTTGACAAGCAGCCGGCTGAATATAAAAACGCTGTTCTTCCAACTGATGTGACAAAGCGTCTCGCAATTG
AAATGGGATCGCCGCTCGGATGGGAGAGATATACAGGCACTGACGGGGACATTCTCGGAATCGACCAGTTCGGTGCATCA
GCTCCTGGCGAAACGATCATGAAAGAATACGGTTTTACGCCTGCGAATGTAGTTGACCGGGTGAAAAAACTGTTAAATCG
CTAA

Upstream 100 bases:

>100_bases
ATTCGTCATTTTTCGCCCAGCTTTTGAGCTGAAATGGTTGTGAAAACCGATGGGTAGATTTATGATAAGAAAGTAGAGTC
CATACAGGAAGGGGATCATA

Downstream 100 bases:

>100_bases
TCGGGCATATGAAAGAGAATGATCTGCGGATCATTCTCTTTTTTTCGTTTCGACAAAATTAGTCGCTTCTTTTATCATCA
TCAGACAATTATTTCTAACC

Product: Tkt

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MKTIELKSVATIRTLSIDAIEKAKSGHPGMPMGTAPMAYALWTKMMNVSPENPNWFNRDRFVLSAGHGSMLLYSMLHLSG
YDVSIEDLKNFRQWGSKTPGHPEFGHTPGVDATTGPLGQGIGMAVGMALAERHLAETYNRDDYRVVDHYTYSICGDGDLM
EGISSEAASLAGHLNLGRLIVLYDSNDISLDGELNRSFSENVKQRFEAMNWEVLYVEDGNNIAEITAAIEKAKQNEKQPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGSEEAKLTKEAYEWTYEEDFYVPSEVYEHFNETVKEAGKKKEAEWNELFSAYKK
AHPELAEELELAIKGELPEGWDQKVPVYEKGSSLASRASSGEVLNGIAQQVPFFFGGSADLAGSNKTTIKNGGDVSAKDY
AGRNIWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPIEQLA
SLRALPNLSVIRPADGNETAAAWKLALQSKDQPTALVLTRQNLPTIDQSAETAYEGVKKGAYVVSKSQNEKPEAILLASG
SEVGLALDAQSELQKEGIDVSVVSVPSWDRFDKQPAEYKNAVLPTDVTKRLAIEMGSPLGWERYTGTDGDILGIDQFGAS
APGETIMKEYGFTPANVVDRVKKLLNR

Sequences:

>Translated_667_residues
MKTIELKSVATIRTLSIDAIEKAKSGHPGMPMGTAPMAYALWTKMMNVSPENPNWFNRDRFVLSAGHGSMLLYSMLHLSG
YDVSIEDLKNFRQWGSKTPGHPEFGHTPGVDATTGPLGQGIGMAVGMALAERHLAETYNRDDYRVVDHYTYSICGDGDLM
EGISSEAASLAGHLNLGRLIVLYDSNDISLDGELNRSFSENVKQRFEAMNWEVLYVEDGNNIAEITAAIEKAKQNEKQPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGSEEAKLTKEAYEWTYEEDFYVPSEVYEHFNETVKEAGKKKEAEWNELFSAYKK
AHPELAEELELAIKGELPEGWDQKVPVYEKGSSLASRASSGEVLNGIAQQVPFFFGGSADLAGSNKTTIKNGGDVSAKDY
AGRNIWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPIEQLA
SLRALPNLSVIRPADGNETAAAWKLALQSKDQPTALVLTRQNLPTIDQSAETAYEGVKKGAYVVSKSQNEKPEAILLASG
SEVGLALDAQSELQKEGIDVSVVSVPSWDRFDKQPAEYKNAVLPTDVTKRLAIEMGSPLGWERYTGTDGDILGIDQFGAS
APGETIMKEYGFTPANVVDRVKKLLNR
>Mature_667_residues
MKTIELKSVATIRTLSIDAIEKAKSGHPGMPMGTAPMAYALWTKMMNVSPENPNWFNRDRFVLSAGHGSMLLYSMLHLSG
YDVSIEDLKNFRQWGSKTPGHPEFGHTPGVDATTGPLGQGIGMAVGMALAERHLAETYNRDDYRVVDHYTYSICGDGDLM
EGISSEAASLAGHLNLGRLIVLYDSNDISLDGELNRSFSENVKQRFEAMNWEVLYVEDGNNIAEITAAIEKAKQNEKQPT
LIEVKTTIGFGSPNRAGTSGVHGAPLGSEEAKLTKEAYEWTYEEDFYVPSEVYEHFNETVKEAGKKKEAEWNELFSAYKK
AHPELAEELELAIKGELPEGWDQKVPVYEKGSSLASRASSGEVLNGIAQQVPFFFGGSADLAGSNKTTIKNGGDVSAKDY
AGRNIWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPIEQLA
SLRALPNLSVIRPADGNETAAAWKLALQSKDQPTALVLTRQNLPTIDQSAETAYEGVKKGAYVVSKSQNEKPEAILLASG
SEVGLALDAQSELQKEGIDVSVVSVPSWDRFDKQPAEYKNAVLPTDVTKRLAIEMGSPLGWERYTGTDGDILGIDQFGAS
APGETIMKEYGFTPANVVDRVKKLLNR

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=599, Percent_Identity=27.212020033389, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI4507521, Length=599, Percent_Identity=27.212020033389, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI133778974, Length=615, Percent_Identity=27.3170731707317, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=671, Percent_Identity=23.2488822652757, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI225637463, Length=573, Percent_Identity=24.0837696335079, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI225637461, Length=598, Percent_Identity=23.5785953177258, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994911, Length=659, Percent_Identity=50.3793626707132, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=660, Percent_Identity=48.6363636363636, Blast_Score=629, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=597, Percent_Identity=27.9731993299832, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=49.7014925373134, Blast_Score=639, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=47.4702380952381, Blast_Score=603, Evalue=1e-173,
Organism=Drosophila melanogaster, GI45551847, Length=605, Percent_Identity=27.603305785124, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI45550715, Length=605, Percent_Identity=27.603305785124, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24666278, Length=611, Percent_Identity=27.4959083469722, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645119, Length=568, Percent_Identity=26.7605633802817, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72637; Mature: 72637

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00037 MYB_1 ; PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIELKSVATIRTLSIDAIEKAKSGHPGMPMGTAPMAYALWTKMMNVSPENPNWFNRDR
CCEEECCCCEEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
FVLSAGHGSMLLYSMLHLSGYDVSIEDLKNFRQWGSKTPGHPEFGHTPGVDATTGPLGQG
EEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
IGMAVGMALAERHLAETYNRDDYRVVDHYTYSICGDGDLMEGISSEAASLAGHLNLGRLI
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEE
VLYDSNDISLDGELNRSFSENVKQRFEAMNWEVLYVEDGNNIAEITAAIEKAKQNEKQPT
EEECCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCC
LIEVKTTIGFGSPNRAGTSGVHGAPLGSEEAKLTKEAYEWTYEEDFYVPSEVYEHFNETV
EEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KEAGKKKEAEWNELFSAYKKAHPELAEELELAIKGELPEGWDQKVPVYEKGSSLASRASS
HHHCCCCCCHHHHHHHHHHHHCHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHCCC
GEVLNGIAQQVPFFFGGSADLAGSNKTTIKNGGDVSAKDYAGRNIWFGVREFAMGAALNG
CHHHHHHHHHCCEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCEEHHHHHHHHHHHCCC
MALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPIEQLA
EEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRALPNLSVIRPADGNETAAAWKLALQSKDQPTALVLTRQNLPTIDQSAETAYEGVKKG
HHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
AYVVSKSQNEKPEAILLASGSEVGLALDAQSELQKEGIDVSVVSVPSWDRFDKQPAEYKN
EEEEECCCCCCCCEEEEECCCCCEEEECCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHC
AVLPTDVTKRLAIEMGSPLGWERYTGTDGDILGIDQFGASAPGETIMKEYGFTPANVVDR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHH
VKKLLNR
HHHHHCC
>Mature Secondary Structure
MKTIELKSVATIRTLSIDAIEKAKSGHPGMPMGTAPMAYALWTKMMNVSPENPNWFNRDR
CCEEECCCCEEEEEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
FVLSAGHGSMLLYSMLHLSGYDVSIEDLKNFRQWGSKTPGHPEFGHTPGVDATTGPLGQG
EEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
IGMAVGMALAERHLAETYNRDDYRVVDHYTYSICGDGDLMEGISSEAASLAGHLNLGRLI
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEE
VLYDSNDISLDGELNRSFSENVKQRFEAMNWEVLYVEDGNNIAEITAAIEKAKQNEKQPT
EEECCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCC
LIEVKTTIGFGSPNRAGTSGVHGAPLGSEEAKLTKEAYEWTYEEDFYVPSEVYEHFNETV
EEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
KEAGKKKEAEWNELFSAYKKAHPELAEELELAIKGELPEGWDQKVPVYEKGSSLASRASS
HHHCCCCCCHHHHHHHHHHHHCHHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHCCC
GEVLNGIAQQVPFFFGGSADLAGSNKTTIKNGGDVSAKDYAGRNIWFGVREFAMGAALNG
CHHHHHHHHHCCEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCEEHHHHHHHHHHHCCC
MALHGGLRVFGGTFFVFSDYLRPAIRLAALMGLPVTYVFTHDSIAVGEDGPTHEPIEQLA
EEEECCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRALPNLSVIRPADGNETAAAWKLALQSKDQPTALVLTRQNLPTIDQSAETAYEGVKKG
HHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
AYVVSKSQNEKPEAILLASGSEVGLALDAQSELQKEGIDVSVVSVPSWDRFDKQPAEYKN
EEEEECCCCCCCCEEEEECCCCCEEEECCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHC
AVLPTDVTKRLAIEMGSPLGWERYTGTDGDILGIDQFGASAPGETIMKEYGFTPANVVDR
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHCCCCCCHHHHHHHHCCCHHHHHHH
VKKLLNR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]