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The map label for this gene is tetB [H]

Identifier: 52785700

GI number: 52785700

Start: 1904017

End: 1904790

Strand: Direct

Name: tetB [H]

Synonym: BLi01942

Alternate gene names: 52785700

Gene position: 1904017-1904790 (Clockwise)

Preceding gene: 52785699

Following gene: 52785701

Centisome position: 45.09

GC content: 45.61

Gene sequence:

>774_bases
TTGATTGTACATTATATTCATTGGTCGTTTCTGTTTATTCTGCCGATGGCAGTGCTGATGGCGATTCCTTTCTTCTTTAG
AAATATGCCTGATGAAGCCGCTGCAAAAGCAAACCTGGATATCATTGGGATCGGACTGCTGACAATCAGCATTGTGATGT
TCGCTGTATATATATCGCTGTATCATGTCTTTTATTTACTGGCGGGCATTTTTTGCTTGATTGGAGCTGCAGTTCATACC
CGACATGCAGAACATCCGTTTATTGACCGTTCTTTAATAAAGAATCGCCGATATATAGGCGTCGTTTTGGCAGGATGTAC
TGTATTGGGAAGCGTTGCGGGCGGAGCCCTTACAGATCGCTTCGGCAGCCGGTTTGTTTTTACTCTTGGATGGTTATTGA
TCTTGTCAACCATGGCAGCCGCGTCACAGGTCGGCGACCGGACACCATGGTTGATGACGATTATGCTCGTGTTTATATTT
GGCGGTCTTTCATTTGTGAAAACGGCAATTTCAAACAGTACCGCAGAAAGCTTGGAAGAAAAGGCTGCAGGCGCTGGAAT
GGGGATGCTGAACTTTGCCTGTTTTTTATCTGAAGGAATAGGCGTCGCATTAGCAGGAGGCTTGATGGCAGTGCACGGGT
TTGGCTATTCTGCGCTTCCGGCAATGAACGATGCCTGGAGTGCTGTATTCAGCCGCTCGTTTGCCATATTCACAGTTTTT
GTATTGGCTGGCGGATTGCTATATTTATTGACTTGCAAACGCAAAAAATCTTAG

Upstream 100 bases:

>100_bases
ACGCGCTATGTCCGTCCGGAGGGCCGGGGCAAAGCATTCGGCATTGTCGGATCACTGGTGGCAATGGGCGAGGGAATAGG
TCCGGCCATCGGCGGAATGA

Downstream 100 bases:

>100_bases
GATATTCGAGTGGTTGGGCGGGAAAGCCCAGCCGTTTTTTATGCTGACTCGATTTTCTGAAACATAATGAAAAGAAAATC
GTATTTGATGTAAAGCTTCT

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MIVHYIHWSFLFILPMAVLMAIPFFFRNMPDEAAAKANLDIIGIGLLTISIVMFAVYISLYHVFYLLAGIFCLIGAAVHT
RHAEHPFIDRSLIKNRRYIGVVLAGCTVLGSVAGGALTDRFGSRFVFTLGWLLILSTMAAASQVGDRTPWLMTIMLVFIF
GGLSFVKTAISNSTAESLEEKAAGAGMGMLNFACFLSEGIGVALAGGLMAVHGFGYSALPAMNDAWSAVFSRSFAIFTVF
VLAGGLLYLLTCKRKKS

Sequences:

>Translated_257_residues
MIVHYIHWSFLFILPMAVLMAIPFFFRNMPDEAAAKANLDIIGIGLLTISIVMFAVYISLYHVFYLLAGIFCLIGAAVHT
RHAEHPFIDRSLIKNRRYIGVVLAGCTVLGSVAGGALTDRFGSRFVFTLGWLLILSTMAAASQVGDRTPWLMTIMLVFIF
GGLSFVKTAISNSTAESLEEKAAGAGMGMLNFACFLSEGIGVALAGGLMAVHGFGYSALPAMNDAWSAVFSRSFAIFTVF
VLAGGLLYLLTCKRKKS
>Mature_257_residues
MIVHYIHWSFLFILPMAVLMAIPFFFRNMPDEAAAKANLDIIGIGLLTISIVMFAVYISLYHVFYLLAGIFCLIGAAVHT
RHAEHPFIDRSLIKNRRYIGVVLAGCTVLGSVAGGALTDRFGSRFVFTLGWLLILSTMAAASQVGDRTPWLMTIMLVFIF
GGLSFVKTAISNSTAESLEEKAAGAGMGMLNFACFLSEGIGVALAGGLMAVHGFGYSALPAMNDAWSAVFSRSFAIFTVF
VLAGGLLYLLTCKRKKS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 27772; Mature: 27772

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2844262; 7584024; 9384377 [H]