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The map label for this gene is uppS [H]

Identifier: 52785633

GI number: 52785633

Start: 1826507

End: 1827289

Strand: Direct

Name: uppS [H]

Synonym: BLi01874

Alternate gene names: 52785633

Gene position: 1826507-1827289 (Clockwise)

Preceding gene: 52785632

Following gene: 52785634

Centisome position: 43.26

GC content: 47.13

Gene sequence:

>783_bases
ATGCTCAATATACTCAAAAATTGGAAGAATCAGCATTCGGCTGCTTCCAACATGGAATGTTACACAAAAGAAAATATTTT
AAAAGGAGAAATTCCTGAACATATCGCCATTATTATGGACGGAAACGGCCGCTGGGCAAAGAAGCGGGCGATGCCCCGCA
TCGCGGGTCATCACGAAGGCATGAAAGTGGTCAGACAGACGACAAAGCTTGCCAATGAGCTCGGTGTCAAAGCGTTGACG
CTGTATGCCTTTTCGACGGAAAATTGGAAGCGTCCAAAGCTTGAGGTTGACTTTCTGATGAAGCTGCCTGAAGAGTTTCT
GGGAACGTATCTCCCGGAGCTGGTCGAAGAAAATGTCCGGGTCCGCATGACAGGCGATAGGGAAGGACTGCCGCCCCACA
CGATCCGCGCGGTTGAAAAAGCCATCCGTGATACGGAGAACAATGACGGACTTATTCTTAATTTTGCATTGAATTACGGG
GGACGTGCAGAAATCGTCAGAGCCGCAAAGAAAATTGCCGAAGAAGCCAAAAAAGGCACATTGAATACCGAGGAAATCGA
CGAAAAGCTATTTTCCGATTATTTAATGACAGAAACTTTGCAGGACCCTGATTTGCTGATTCGCACAAGCGGCGAGATCA
GGCTGAGCAACTTCATGCTTTGGCAGCTTGCCTACAGCGAATTTTTATTTACCGATGTATTGTGGCCTGATTTTAAAGAC
GTTCACTTGCTTCAGGCTATCGGAGAATATCAGCGTCGCGGGAGAAGGTTTGGCGGAATTTAG

Upstream 100 bases:

>100_bases
AAAAGACCCTCTCATGTTTACAGGGGGTTTTTTTGTTAATACTGTTGTTATCTAGAACGATATAACAGGAAAGCAACCTT
TTGGGTGATGGAGGACTCTC

Downstream 100 bases:

>100_bases
AGGATGGTGCAGATGAAACAGAGAATATTGACGGGTGTGATCGCGGCAGCGGTTTTTCTGCCGCTCGTGATTTTCGGCGA
GCTGCCGTTCACCCTGCTAG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLNILKNWKNQHSAASNMECYTKENILKGEIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMKVVRQTTKLANELGVKALT
LYAFSTENWKRPKLEVDFLMKLPEEFLGTYLPELVEENVRVRMTGDREGLPPHTIRAVEKAIRDTENNDGLILNFALNYG
GRAEIVRAAKKIAEEAKKGTLNTEEIDEKLFSDYLMTETLQDPDLLIRTSGEIRLSNFMLWQLAYSEFLFTDVLWPDFKD
VHLLQAIGEYQRRGRRFGGI

Sequences:

>Translated_260_residues
MLNILKNWKNQHSAASNMECYTKENILKGEIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMKVVRQTTKLANELGVKALT
LYAFSTENWKRPKLEVDFLMKLPEEFLGTYLPELVEENVRVRMTGDREGLPPHTIRAVEKAIRDTENNDGLILNFALNYG
GRAEIVRAAKKIAEEAKKGTLNTEEIDEKLFSDYLMTETLQDPDLLIRTSGEIRLSNFMLWQLAYSEFLFTDVLWPDFKD
VHLLQAIGEYQRRGRRFGGI
>Mature_260_residues
MLNILKNWKNQHSAASNMECYTKENILKGEIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMKVVRQTTKLANELGVKALT
LYAFSTENWKRPKLEVDFLMKLPEEFLGTYLPELVEENVRVRMTGDREGLPPHTIRAVEKAIRDTENNDGLILNFALNYG
GRAEIVRAAKKIAEEAKKGTLNTEEIDEKLFSDYLMTETLQDPDLLIRTSGEIRLSNFMLWQLAYSEFLFTDVLWPDFKD
VHLLQAIGEYQRRGRRFGGI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=39.8268398268398, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=39.8268398268398, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=46.4601769911504, Blast_Score=210, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=38.5281385281385, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=37.1559633027523, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=33.1838565022422, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=40.0881057268723, Blast_Score=164, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29922; Mature: 29922

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNILKNWKNQHSAASNMECYTKENILKGEIPEHIAIIMDGNGRWAKKRAMPRIAGHHEG
CCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHCCHHH
MKVVRQTTKLANELGVKALTLYAFSTENWKRPKLEVDFLMKLPEEFLGTYLPELVEENVR
HHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCE
VRMTGDREGLPPHTIRAVEKAIRDTENNDGLILNFALNYGGRAEIVRAAKKIAEEAKKGT
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
LNTEEIDEKLFSDYLMTETLQDPDLLIRTSGEIRLSNFMLWQLAYSEFLFTDVLWPDFKD
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHH
VHLLQAIGEYQRRGRRFGGI
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLNILKNWKNQHSAASNMECYTKENILKGEIPEHIAIIMDGNGRWAKKRAMPRIAGHHEG
CCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHCCHHH
MKVVRQTTKLANELGVKALTLYAFSTENWKRPKLEVDFLMKLPEEFLGTYLPELVEENVR
HHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCE
VRMTGDREGLPPHTIRAVEKAIRDTENNDGLILNFALNYGGRAEIVRAAKKIAEEAKKGT
EEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
LNTEEIDEKLFSDYLMTETLQDPDLLIRTSGEIRLSNFMLWQLAYSEFLFTDVLWPDFKD
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHH
VHLLQAIGEYQRRGRRFGGI
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]