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The map label for this gene is rnc [H]

Identifier: 52785573

GI number: 52785573

Start: 1771500

End: 1772249

Strand: Direct

Name: rnc [H]

Synonym: BLi01814

Alternate gene names: 52785573

Gene position: 1771500-1772249 (Clockwise)

Preceding gene: 52785572

Following gene: 52785574

Centisome position: 41.95

GC content: 44.27

Gene sequence:

>750_bases
ATGTCAAAACATTCACATTTCAGAGACAAAAAAATGTTTCAAAAAAAAGCGGAGCAGTTTAAAAAGTTTCAGGAACGGAT
TTCGGTTCAATTTCAAAACGAGAAGCTTTTATATCAAGCGTTTACACATTCATCTTATGTGAATGAGCATCGAAAGAAGC
CATATGAAGATAATGAGAGGCTTGAATTTTTAGGAGACGCCGTTTTGGAACTGACGATTTCTCAATTTTTATACGCCAAA
TACCCGGCGATGAGCGAGGGTGATTTGACGAAATTGAGAGCGGCGATCGTATGCGAGCCTTCTTTGGTTTCCCTGGCCCA
TGAGCTTTCTTTCGGAGAGCTTGTTCTATTGGGAAAAGGAGAGGAAATGACTGGAGGAAGAAAGCGTCCGGCGCTTTTAG
CCGATGTGTTTGAAGCTTTTATCGGTGCGCTCTATCTGGATCAGGGGCTCGAAGCCGTCGTGACTTTTCTGAAAGCGTAC
GTTTTCCCTAAAATCGACGATGGTGCTTTTTCTCATGTGATGGATTTTAAAAGCCAGCTGCAGGAATTTGTACAGCGCGA
CGGGCGAGGCATACTGGAGTATAAAATCCTTCAGGAAAAAGGACCGGCGCACAACCGCGAATTTGAAGCAAATGTATCGC
TAAAAGGAGAAGTACTTGGGGTGGGAAGCGGCCGTTCCAAAAAAGAAGCTGAACAGCATGCCGCTCAAGAAGCGCTCGCG
AAGCTGCAAAAACACCATATGAAACAATAA

Upstream 100 bases:

>100_bases
TATAAATGCGGCTTTAATTTTAATGTTTTGCCCAATGATAAACGAACCTGCCTTTTCATAGGAGGTGAGGTGAACTTGAT
GTGCCCATATGGAGGTTGCT

Downstream 100 bases:

>100_bases
ATCCCCCTTGCAAAAACCAGGGGGATTTCAATGTATTTTGAGCCTTTTCCATAGGGTTATGATAGAATTGTAATACTTTA
ATACATAAGGAGGATCACCA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSKHSHFRDKKMFQKKAEQFKKFQERISVQFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISQFLYAK
YPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGELVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEAVVTFLKAY
VFPKIDDGAFSHVMDFKSQLQEFVQRDGRGILEYKILQEKGPAHNREFEANVSLKGEVLGVGSGRSKKEAEQHAAQEALA
KLQKHHMKQ

Sequences:

>Translated_249_residues
MSKHSHFRDKKMFQKKAEQFKKFQERISVQFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISQFLYAK
YPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGELVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEAVVTFLKAY
VFPKIDDGAFSHVMDFKSQLQEFVQRDGRGILEYKILQEKGPAHNREFEANVSLKGEVLGVGSGRSKKEAEQHAAQEALA
KLQKHHMKQ
>Mature_248_residues
SKHSHFRDKKMFQKKAEQFKKFQERISVQFQNEKLLYQAFTHSSYVNEHRKKPYEDNERLEFLGDAVLELTISQFLYAKY
PAMSEGDLTKLRAAIVCEPSLVSLAHELSFGELVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEAVVTFLKAYV
FPKIDDGAFSHVMDFKSQLQEFVQRDGRGILEYKILQEKGPAHNREFEANVSLKGEVLGVGSGRSKKEAEQHAAQEALAK
LQKHHMKQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=246, Percent_Identity=34.9593495934959, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI155030236, Length=246, Percent_Identity=34.9593495934959, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI29294649, Length=265, Percent_Identity=28.3018867924528, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI29294651, Length=265, Percent_Identity=28.3018867924528, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=34.9056603773585, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17506883, Length=245, Percent_Identity=34.2857142857143, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193202651, Length=245, Percent_Identity=34.2857142857143, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17552834, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323895, Length=217, Percent_Identity=30.8755760368664, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=31.8777292576419, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28385; Mature: 28254

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHSHFRDKKMFQKKAEQFKKFQERISVQFQNEKLLYQAFTHSSYVNEHRKKPYEDNER
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
LEFLGDAVLELTISQFLYAKYPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGELVLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
EEMTGGRKRPALLADVFEAFIGALYLDQGLEAVVTFLKAYVFPKIDDGAFSHVMDFKSQL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QEFVQRDGRGILEYKILQEKGPAHNREFEANVSLKGEVLGVGSGRSKKEAEQHAAQEALA
HHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCEECCEEEECCCCCCHHHHHHHHHHHHHH
KLQKHHMKQ
HHHHHHCCC
>Mature Secondary Structure 
SKHSHFRDKKMFQKKAEQFKKFQERISVQFQNEKLLYQAFTHSSYVNEHRKKPYEDNER
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
LEFLGDAVLELTISQFLYAKYPAMSEGDLTKLRAAIVCEPSLVSLAHELSFGELVLLGKG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECC
EEMTGGRKRPALLADVFEAFIGALYLDQGLEAVVTFLKAYVFPKIDDGAFSHVMDFKSQL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QEFVQRDGRGILEYKILQEKGPAHNREFEANVSLKGEVLGVGSGRSKKEAEQHAAQEALA
HHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCEECCEEEECCCCCCHHHHHHHHHHHHHH
KLQKHHMKQ
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA