BacMap

Definition	Bacillus licheniformis ATCC 14580, complete genome.
Accession	NC_006322
Length	4,222,645

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The map label for this gene is gmk

Identifier: 52785548

GI number: 52785548

Start: 1747612

End: 1748226

Strand: Direct

Name: gmk

Synonym: BLi01789

Alternate gene names: 52785548

Gene position: 1747612-1748226 (Clockwise)

Preceding gene: 52785547

Following gene: 52785549

Centisome position: 41.39

GC content: 48.29

Gene sequence:

>615_bases
ATGAAAGAAAGAGGTTTGTTAATCGTTCTCTCCGGCCCTTCCGGCGTCGGAAAAGGAACAGTCAGGCAGGCGCTGTTTGC
TCAGGAGGACACAAAATTTGAATATTCGATTTCGGTGACGACAAGAAAACCGCGTCAAGGCGAAAGAGACGGCGTCGACT
ACTTTTTTAAGACGCGCGAAGAGTTCGAAGAGATGATCGAGAACAACAAGCTGCTCGAATGGGCCGAATATGTCGGCAAC
TATTACGGAACACCCGTTGACTACGTCGAACAGACGCTTGAAAGCGGAAGGGACGTTTTTCTTGAAATCGAAGTCCAGGG
TGCGCTGCAAGTCAGAAAGGCATTTCCTGAAGGCTTGTTTATCTTTTTGGCGCCTCCGAGCCTCGCCGAATTGAAAAACC
GGATTGTCACAAGAGGGACAGAAACAGAAGCCACGATCGAAAACCGGATGAAAGCGGCGAAGGAAGAAATCGAACTGATG
GACGCCTATGACTATGTTGTCGAAAATGACAGCATTGAGCTTGCGTGCGAAAGAATCAAAGCAATCGTTCTCGCCGAACA
TTTACGGCGCGACCGAGTTGCTCCAAGATATAAGAAAATGCTGGAGGTTGAATAA

Upstream 100 bases:

>100_bases
AGTGACCATATCATCTTATCTGCCGTCCAGCCTGAGACAGTAGCACAAAGGCTTTCCGTTAAAGAAGAAATTATGGATGA
AGGGCAGGGATAAGAGCTTT

Downstream 100 bases:

>100_bases
ATATGCTAGATCCGTCAATTGACTCTTTAATGAACAAACTGGATTCAAAATACACGCTCGTTACCGTATCCGCACGGCGC
GCCCGCGAAATGCAGATGAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MKERGLLIVLSGPSGVGKGTVRQALFAQEDTKFEYSISVTTRKPRQGERDGVDYFFKTREEFEEMIENNKLLEWAEYVGN
YYGTPVDYVEQTLESGRDVFLEIEVQGALQVRKAFPEGLFIFLAPPSLAELKNRIVTRGTETEATIENRMKAAKEEIELM
DAYDYVVENDSIELACERIKAIVLAEHLRRDRVAPRYKKMLEVE

Sequences:

>Translated_204_residues
MKERGLLIVLSGPSGVGKGTVRQALFAQEDTKFEYSISVTTRKPRQGERDGVDYFFKTREEFEEMIENNKLLEWAEYVGN
YYGTPVDYVEQTLESGRDVFLEIEVQGALQVRKAFPEGLFIFLAPPSLAELKNRIVTRGTETEATIENRMKAAKEEIELM
DAYDYVVENDSIELACERIKAIVLAEHLRRDRVAPRYKKMLEVE
>Mature_204_residues
MKERGLLIVLSGPSGVGKGTVRQALFAQEDTKFEYSISVTTRKPRQGERDGVDYFFKTREEFEEMIENNKLLEWAEYVGN
YYGTPVDYVEQTLESGRDVFLEIEVQGALQVRKAFPEGLFIFLAPPSLAELKNRIVTRGTETEATIENRMKAAKEEIELM
DAYDYVVENDSIELACERIKAIVLAEHLRRDRVAPRYKKMLEVE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=186, Percent_Identity=36.0215053763441, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874833, Length=186, Percent_Identity=36.0215053763441, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI4504221, Length=186, Percent_Identity=36.0215053763441, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI14780902, Length=183, Percent_Identity=30.0546448087432, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI21361598, Length=184, Percent_Identity=29.8913043478261, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI4505237, Length=137, Percent_Identity=37.2262773722628, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI262118255, Length=137, Percent_Identity=37.2262773722628, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI262118259, Length=137, Percent_Identity=37.2262773722628, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI262118263, Length=137, Percent_Identity=37.2262773722628, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI38570142, Length=132, Percent_Identity=34.8484848484849, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI111154074, Length=174, Percent_Identity=27.0114942528736, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI186700627, Length=122, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI186700629, Length=122, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI186972120, Length=122, Percent_Identity=29.5081967213115, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI21389483, Length=181, Percent_Identity=25.414364640884, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI192447426, Length=177, Percent_Identity=29.9435028248588, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4557529, Length=177, Percent_Identity=29.9435028248588, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI52630447, Length=152, Percent_Identity=28.2894736842105, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI261862237, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI119943108, Length=177, Percent_Identity=29.3785310734463, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI21536464, Length=123, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI119943106, Length=177, Percent_Identity=29.3785310734463, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI148539628, Length=181, Percent_Identity=29.8342541436464, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI148539578, Length=181, Percent_Identity=29.8342541436464, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI218156270, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI218156340, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI91199538, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI218156338, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=42.7860696517413, Blast_Score=161, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=38.3720930232558, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=38.3720930232558, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71988048, Length=126, Percent_Identity=32.5396825396825, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71988041, Length=126, Percent_Identity=32.5396825396825, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17556244, Length=136, Percent_Identity=34.5588235294118, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=133, Percent_Identity=30.0751879699248, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=45.9016393442623, Blast_Score=164, Evalue=8e-42,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=39.010989010989, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI161077626, Length=176, Percent_Identity=30.1136363636364, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45554489, Length=176, Percent_Identity=30.1136363636364, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640542, Length=176, Percent_Identity=30.1136363636364, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=30.1136363636364, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116007136, Length=176, Percent_Identity=30.1136363636364, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=37.007874015748, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=37.007874015748, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=37.007874015748, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221330166, Length=137, Percent_Identity=35.7664233576642, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330162, Length=137, Percent_Identity=35.7664233576642, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330164, Length=137, Percent_Identity=35.7664233576642, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360700, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641282, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554818, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641280, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554804, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554791, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077754, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077752, Length=184, Percent_Identity=29.8913043478261, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554813, Length=184, Percent_Identity=29.8913043478261, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648808, Length=126, Percent_Identity=29.3650793650794, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362230, Length=126, Percent_Identity=29.3650793650794, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078487, Length=126, Percent_Identity=29.3650793650794, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078485, Length=126, Percent_Identity=29.3650793650794, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648810, Length=126, Percent_Identity=29.3650793650794, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281362232, Length=126, Percent_Identity=29.3650793650794, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_BACLD (Q65JT0)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_078962.2
- RefSeq:   YP_091377.1
- HSSP:   P15454
- ProteinModelPortal:   Q65JT0
- SMR:   Q65JT0
- STRING:   Q65JT0
- EnsemblBacteria:   EBBACT00000054211
- EnsemblBacteria:   EBBACT00000059684
- GeneID:   3030944
- GeneID:   3098229
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi01789
- KEGG:   bli:BL02293
- NMPDR:   fig|279010.5.peg.1731
- eggNOG:   COG0194
- GeneTree:   EBGT00050000002748
- HOGENOM:   HBG671982
- ProtClustDB:   PRK00300
- BioCyc:   BLIC279010-1:BLI01789-MONOMER
- BioCyc:   BLIC279010:BL02293-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23469; Mature: 23469

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERGLLIVLSGPSGVGKGTVRQALFAQEDTKFEYSISVTTRKPRQGERDGVDYFFKTRE
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHH
EFEEMIENNKLLEWAEYVGNYYGTPVDYVEQTLESGRDVFLEIEVQGALQVRKAFPEGLF
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECHHHHHHHHCCCCEE
IFLAPPSLAELKNRIVTRGTETEATIENRMKAAKEEIELMDAYDYVVENDSIELACERIK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AIVLAEHLRRDRVAPRYKKMLEVE
HHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MKERGLLIVLSGPSGVGKGTVRQALFAQEDTKFEYSISVTTRKPRQGERDGVDYFFKTRE
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHH
EFEEMIENNKLLEWAEYVGNYYGTPVDYVEQTLESGRDVFLEIEVQGALQVRKAFPEGLF
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECHHHHHHHHCCCCEE
IFLAPPSLAELKNRIVTRGTETEATIENRMKAAKEEIELMDAYDYVVENDSIELACERIK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AIVLAEHLRRDRVAPRYKKMLEVE
HHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA