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The map label for this gene is gltT [H]

Identifier: 52784872

GI number: 52784872

Start: 1100120

End: 1101406

Strand: Reverse

Name: gltT [H]

Synonym: BLi01100

Alternate gene names: 52784872

Gene position: 1101406-1100120 (Counterclockwise)

Preceding gene: 52784876

Following gene: 52784871

Centisome position: 26.08

GC content: 48.41

Gene sequence:

>1287_bases
ATGAAAAGACTTAAATTCGGATTAGCCACACAAATTTTCCTCGGGCTGATTTTAGGTGTTGCAGCAGGAGCGATTTGGTT
CGGAAATCCTGCGGTTGCAACGTATCTGCAGCCCGTCGGCGATTTGTTCTTAAGATTAATCAAAATGATTGTGATTCCTA
TTGTCGTTTCAAGCTTGATTGTCGGGGTTGCGGGGGCCGGCAGCGGCAAAAAGGTCGGCAGGCTCGGCTTTCGGACGATC
CTTTACTTTGAAATCATTACGACTTTTGCGATTGTGCTCGGACTTCTCCTCGGAAACATCATTCAGCCTGGGCACGGCGT
AAACTTTTCTGGTGCTGAAAAACAGGATATCAGCCAATATGTAGAAACAGAAAAAGAAGCAAGCACCAAATCTGTCGCAG
ACACGTTCCTGCACATTGTGCCGACAAACTTTTTCCAGTCGCTCGCTGAAGGCGATCTGCTTGCGATCATTTGCTTCACT
GTTCTGTTCGCACTCGGGGTGTCTGCCATAGGCGAAAAAGGCAAGCCTGTGCTCTCCTTTTTCGAGGCAACGTCTCAAGC
CATGTTCCACGTCGTCAACATCGTTATGAAATTCGCGCCGTTCGGCGTTTTTGCTTTAATTGGCGTGACGGTTTCAAAAT
TTGGTTTTTCTTCGCTTTTATCATTGGGAAAGCTCGTTTTACTTGTCTACCTGGCTCTTGCTTTCTTCTTGATCGTTATC
TTTGGGATCGTCGGCAAGCTTTGCGGTATCAATATATTTAAATTTTTGGCTTTTTTGAAAGATGAGCTTCTTCTTGCGTA
CAGTACATCAAGCTCTGAAACCGTGCTTCCGCGCGTCATGGAAAAGATGGAGAAAATCGGCTGCCCGAAAGGCATCGTGT
CGTTTGTCATTCCGATCGGCTATACATTTAACCTTGACGGCTCTGTCCTGTATCAAGCGATCGCGGCGCTGTTTCTGGCG
CAGGTCTACGGCATCGATCTATCCATTGGACAGCAGCTCACGTTAATCCTTGTTCTGATGGTCACTTCTAAAGGTATGGC
TGCCGTTCCCGGCACATCTTTCGTCGTTCTTCTTGCGACTTTGGGCACGATCGGCGTTCCTGCTGAAGGGCTGGCCTTCA
TTGCCGGAGTCGACCGGATTATGGACATGGCGAGAACGGTCGTCAACTTGACCGGAAACGCTCTCGCCGCTGTGGTCATG
TCAAAATGGGAAGGTGAATATGACGCCGTTAAAGGGCAGAACGTCTTAAATCAACGGGAGCCGGCAGATATAGAAGTATC
CGGCTGA

Upstream 100 bases:

>100_bases
TTTTTTTAATGGACGAGCTGCTTTTTCTTTCGCTATACTTAATTTACGATCTCAGTTTAATATTCTAGTATAAAATTAAG
TATGCGTTGGGAGGGCATCT

Downstream 100 bases:

>100_bases
CCCCCTTTTCTATCAAAAAACGTATGTTTTCCATCCCGGGAAGACATACGTTTTTTTAAAAAAATATACGAATTTCTCAA
GCAACCTGTCCAAACAACTT

Product: GltT

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKRLKFGLATQIFLGLILGVAAGAIWFGNPAVATYLQPVGDLFLRLIKMIVIPIVVSSLIVGVAGAGSGKKVGRLGFRTI
LYFEIITTFAIVLGLLLGNIIQPGHGVNFSGAEKQDISQYVETEKEASTKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGVSAIGEKGKPVLSFFEATSQAMFHVVNIVMKFAPFGVFALIGVTVSKFGFSSLLSLGKLVLLVYLALAFFLIVI
FGIVGKLCGINIFKFLAFLKDELLLAYSTSSSETVLPRVMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQAIAALFLA
QVYGIDLSIGQQLTLILVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALAAVVM
SKWEGEYDAVKGQNVLNQREPADIEVSG

Sequences:

>Translated_428_residues
MKRLKFGLATQIFLGLILGVAAGAIWFGNPAVATYLQPVGDLFLRLIKMIVIPIVVSSLIVGVAGAGSGKKVGRLGFRTI
LYFEIITTFAIVLGLLLGNIIQPGHGVNFSGAEKQDISQYVETEKEASTKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGVSAIGEKGKPVLSFFEATSQAMFHVVNIVMKFAPFGVFALIGVTVSKFGFSSLLSLGKLVLLVYLALAFFLIVI
FGIVGKLCGINIFKFLAFLKDELLLAYSTSSSETVLPRVMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQAIAALFLA
QVYGIDLSIGQQLTLILVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALAAVVM
SKWEGEYDAVKGQNVLNQREPADIEVSG
>Mature_428_residues
MKRLKFGLATQIFLGLILGVAAGAIWFGNPAVATYLQPVGDLFLRLIKMIVIPIVVSSLIVGVAGAGSGKKVGRLGFRTI
LYFEIITTFAIVLGLLLGNIIQPGHGVNFSGAEKQDISQYVETEKEASTKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGVSAIGEKGKPVLSFFEATSQAMFHVVNIVMKFAPFGVFALIGVTVSKFGFSSLLSLGKLVLLVYLALAFFLIVI
FGIVGKLCGINIFKFLAFLKDELLLAYSTSSSETVLPRVMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQAIAALFLA
QVYGIDLSIGQQLTLILVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALAAVVM
SKWEGEYDAVKGQNVLNQREPADIEVSG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=492, Percent_Identity=27.6422764227642, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4827012, Length=432, Percent_Identity=27.3148148148148, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI66773030, Length=465, Percent_Identity=29.0322580645161, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI21314632, Length=443, Percent_Identity=29.1196388261851, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI169790839, Length=475, Percent_Identity=25.0526315789474, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI5032093, Length=417, Percent_Identity=29.9760191846523, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI194239697, Length=264, Percent_Identity=30.6818181818182, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223468566, Length=262, Percent_Identity=28.6259541984733, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=28.0442804428044, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI262359914, Length=395, Percent_Identity=24.5569620253165, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI301601644, Length=180, Percent_Identity=32.2222222222222, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790514, Length=428, Percent_Identity=54.2056074766355, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=38.7706855791962, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=28.7128712871287, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1789473, Length=390, Percent_Identity=23.5897435897436, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=421, Percent_Identity=31.5914489311164, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71996953, Length=468, Percent_Identity=28.2051282051282, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71983099, Length=452, Percent_Identity=27.4336283185841, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=452, Percent_Identity=27.4336283185841, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=26.6094420600858, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=429, Percent_Identity=23.0769230769231, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=416, Percent_Identity=25, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24583025, Length=412, Percent_Identity=25.2427184466019, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17137668, Length=412, Percent_Identity=25.2427184466019, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24583023, Length=412, Percent_Identity=25.2427184466019, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI281360483, Length=463, Percent_Identity=28.2937365010799, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137666, Length=463, Percent_Identity=28.2937365010799, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281360481, Length=463, Percent_Identity=28.2937365010799, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45585; Mature: 45585

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEEECC
>Mature Secondary Structure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CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]