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The map label for this gene is gsaB

Identifier: 52784696

GI number: 52784696

Start: 916407

End: 917705

Strand: Reverse

Name: gsaB

Synonym: BLi00898

Alternate gene names: 52784696

Gene position: 917705-916407 (Counterclockwise)

Preceding gene: 52784699

Following gene: 52784695

Centisome position: 21.73

GC content: 52.73

Gene sequence:

>1299_bases
ATGCAGCATACTCAATCTGAAAAGCTTCATGAAGAAGCTCTTCAACATATAGTCGGAGGCGTCAACAGCCCCTCAAGGTC
TTACAAAGCGGTCGGCGGAGGTTCTCCCGTCGCGATGGAAAGGGGAAGCGGCGCTTATTTTTGGGATGTGGACGGCAACA
AATACATAGACTACCTTGCCGCGTACGGACCGATTATTACGGGCCACGCCCACCCGCATATCACGAAAGCGATTCAAACA
GCTGCTGAGAACGGGGTGCTTTACGGTACGCCGACAAAGCATGAAGTGACATTTGCCAAGATGCTTAAGGAAGCGATTCC
TGCCTTGGATAAAGTGAGATTCGTCAATTCGGGAACGGAAGCTGTGATGACGACGATTCGCGTCGCCCGGGCCTATACAG
GCAGAACGAAAATCATCAAGTTCGCCGGCTGCTACCACGGCCATTCCGATCTTGTGCTGGTGGCGGCCGGTTCAGGACCG
TCAACGCTCGGCACGCCTGATTCCGCCGGGGTTCCAAAAAGCATCGCCAACGAGGTGATTACCGTTCCTTTCAATGATAT
CGACAGCTATAAAGAAGCGCTCGATAAATGGGGGAACGATATTGCGGCAGTCCTCGTTGAACCGATTGTCGGAAACTTCG
GGATCGTCGAACCGAAGAGCGGATTCCTCGAGCAGGTCAATGAACTTACGCATAACGCGGGAGCCCTGGTCATCTACGAT
GAAGTCATTACCGCTTTCCGCTTTATGTACGGCGGCGCCCAGGATCTTCTTGGCGTCAAACCTGATTTGACGGCGCTCGG
CAAAATCATCGGCGGCGGCCTGCCGATCGGCGCCTACGGAGGCAGAAAAGAGATTATGGAACAAGTCGCACCGCTCGGAC
CTGCTTATCAAGCGGGCACGATGGCGGGGAATCCGGCTTCCATCCTCTCTGGCATCGCCTGCCTTGAAGTGCTGAAAGAA
AAAGGCACATACGAAAAACTTGACCGCCTCGGCGCCATGCTTGAAGAAGGCATCCTGGCACATGCCGAGACCCACGGCAT
CGACATCACTGTCAACCGTCTAAAAGGCGCGCTCACCGTATACTTCACGAACGAAAAAGTCGAAAACTATGAGCAAGCCG
AAAATACGGACGGAGACATGTTCGCGGCCTTTTTCAAACTGATGCTTGAGCGCGGAATCAATCTTGCGCCTTCAAAATAT
GAAGCATGGTTTATCACCACCGCGCACACGGAAGAGGACATTAAAGATACGCTCAAAGCCGTGGATGACTCATTTAAACA
ATTGAAACAGCGCATGTAA

Upstream 100 bases:

>100_bases
GTTCAAATGTTCGGCGGCTTCTTTTTTGCGCTCTGTCCGCCTCGTGTTACAATATAGAAAATATAGAAATAGATAAAGGT
GCAAAAATGAGGAGGATATT

Downstream 100 bases:

>100_bases
AAAGAGAGCGGATCCGCTCTCTTTTTTATCAAATGCGGAGCACTTTGAAAGCGCGGTGAACAGGCACTTTCCGCCGGCTT
GTCTTTCTTTTTTGTCAATG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MQHTQSEKLHEEALQHIVGGVNSPSRSYKAVGGGSPVAMERGSGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAIQT
AAENGVLYGTPTKHEVTFAKMLKEAIPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPKSIANEVITVPFNDIDSYKEALDKWGNDIAAVLVEPIVGNFGIVEPKSGFLEQVNELTHNAGALVIYD
EVITAFRFMYGGAQDLLGVKPDLTALGKIIGGGLPIGAYGGRKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKE
KGTYEKLDRLGAMLEEGILAHAETHGIDITVNRLKGALTVYFTNEKVENYEQAENTDGDMFAAFFKLMLERGINLAPSKY
EAWFITTAHTEEDIKDTLKAVDDSFKQLKQRM

Sequences:

>Translated_432_residues
MQHTQSEKLHEEALQHIVGGVNSPSRSYKAVGGGSPVAMERGSGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAIQT
AAENGVLYGTPTKHEVTFAKMLKEAIPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPKSIANEVITVPFNDIDSYKEALDKWGNDIAAVLVEPIVGNFGIVEPKSGFLEQVNELTHNAGALVIYD
EVITAFRFMYGGAQDLLGVKPDLTALGKIIGGGLPIGAYGGRKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKE
KGTYEKLDRLGAMLEEGILAHAETHGIDITVNRLKGALTVYFTNEKVENYEQAENTDGDMFAAFFKLMLERGINLAPSKY
EAWFITTAHTEEDIKDTLKAVDDSFKQLKQRM
>Mature_432_residues
MQHTQSEKLHEEALQHIVGGVNSPSRSYKAVGGGSPVAMERGSGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAIQT
AAENGVLYGTPTKHEVTFAKMLKEAIPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPKSIANEVITVPFNDIDSYKEALDKWGNDIAAVLVEPIVGNFGIVEPKSGFLEQVNELTHNAGALVIYD
EVITAFRFMYGGAQDLLGVKPDLTALGKIIGGGLPIGAYGGRKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKE
KGTYEKLDRLGAMLEEGILAHAETHGIDITVNRLKGALTVYFTNEKVENYEQAENTDGDMFAAFFKLMLERGINLAPSKY
EAWFITTAHTEEDIKDTLKAVDDSFKQLKQRM

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=317, Percent_Identity=33.4384858044164, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=27.5964391691395, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI37574042, Length=376, Percent_Identity=27.9255319148936, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI24119277, Length=331, Percent_Identity=28.3987915407855, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226442705, Length=376, Percent_Identity=27.1276595744681, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442709, Length=327, Percent_Identity=28.1345565749235, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI284507298, Length=261, Percent_Identity=31.4176245210728, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=48.1220657276995, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=28.9044289044289, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=30.5555555555556, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789759, Length=295, Percent_Identity=32.2033898305085, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788044, Length=310, Percent_Identity=32.258064516129, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1787560, Length=347, Percent_Identity=28.5302593659942, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786991, Length=377, Percent_Identity=23.342175066313, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=377, Percent_Identity=29.4429708222812, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=346, Percent_Identity=29.1907514450867, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=362, Percent_Identity=25.9668508287293, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=217, Percent_Identity=31.3364055299539, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71981843, Length=111, Percent_Identity=34.2342342342342, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=359, Percent_Identity=28.133704735376, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357415, Length=353, Percent_Identity=30.3116147308782, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356575, Length=325, Percent_Identity=28.6153846153846, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161085790, Length=335, Percent_Identity=28.0597014925373, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28574759, Length=335, Percent_Identity=28.0597014925373, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA1_BACLD (Q65M82)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_078122.1
- RefSeq:   YP_090525.1
- ProteinModelPortal:   Q65M82
- SMR:   Q65M82
- STRING:   Q65M82
- EnsemblBacteria:   EBBACT00000055826
- EnsemblBacteria:   EBBACT00000062587
- GeneID:   3029738
- GeneID:   3098858
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00898
- KEGG:   bli:BL03060
- NMPDR:   fig|279010.5.peg.1510
- eggNOG:   COG0001
- GeneTree:   EBGT00070000031737
- HOGENOM:   HBG725944
- OMA:   VENYEQA
- ProtClustDB:   PRK12389
- BioCyc:   BLIC279010-1:BLI00898-MONOMER
- BioCyc:   BLIC279010:BL03060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46538; Mature: 46538

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHTQSEKLHEEALQHIVGGVNSPSRSYKAVGGGSPVAMERGSGAYFWDVDGNKYIDYLA
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCEEEEECCCCHHHHHHH
AYGPIITGHAHPHITKAIQTAAENGVLYGTPTKHEVTFAKMLKEAIPALDKVRFVNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVI
HHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCEE
TVPFNDIDSYKEALDKWGNDIAAVLVEPIVGNFGIVEPKSGFLEQVNELTHNAGALVIYD
EECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEHH
EVITAFRFMYGGAQDLLGVKPDLTALGKIIGGGLPIGAYGGRKEIMEQVAPLGPAYQAGT
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
MAGNPASILSGIACLEVLKEKGTYEKLDRLGAMLEEGILAHAETHGIDITVNRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHCCEEEEEECCCCEEEE
YFTNEKVENYEQAENTDGDMFAAFFKLMLERGINLAPSKYEAWFITTAHTEEDIKDTLKA
EEECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
VDDSFKQLKQRM
HHHHHHHHHHCC
>Mature Secondary Structure
MQHTQSEKLHEEALQHIVGGVNSPSRSYKAVGGGSPVAMERGSGAYFWDVDGNKYIDYLA
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCEEEEECCCCHHHHHHH
AYGPIITGHAHPHITKAIQTAAENGVLYGTPTKHEVTFAKMLKEAIPALDKVRFVNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVI
HHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCEE
TVPFNDIDSYKEALDKWGNDIAAVLVEPIVGNFGIVEPKSGFLEQVNELTHNAGALVIYD
EECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEHH
EVITAFRFMYGGAQDLLGVKPDLTALGKIIGGGLPIGAYGGRKEIMEQVAPLGPAYQAGT
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
MAGNPASILSGIACLEVLKEKGTYEKLDRLGAMLEEGILAHAETHGIDITVNRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHCCEEEEEECCCCEEEE
YFTNEKVENYEQAENTDGDMFAAFFKLMLERGINLAPSKYEAWFITTAHTEEDIKDTLKA
EEECCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
VDDSFKQLKQRM
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA