Click here to switch to the map view.

The map label for this gene is purL

Identifier: 52784500

GI number: 52784500

Start: 701703

End: 703931

Strand: Direct

Name: purL

Synonym: BLi00699

Alternate gene names: 52784500

Gene position: 701703-703931 (Clockwise)

Preceding gene: 52784499

Following gene: 52784501

Centisome position: 16.62

GC content: 52.13

Gene sequence:

>2229_bases
ATGTCGCTACTGCTTGAACCAAGTCAAGAACAAATTAAGGAAGAGAAACTTTATCAGCAAATGGGTGTCAGCGATGACGA
GTTTGCCATGATTGAATCGATTCTCGGAAGGCTTCCAAACTATACGGAAATCGGGATTTTTTCAGTCATGTGGTCAGAGC
ACTGCAGCTACAAAAATTCCAAGCCGATCCTGAAAAAGTTCCCGACAAAAGGCGAACGCGTCCTGCAAGGACCGGGGGAA
GGCGCAGGAATCGTCGATATCGGCGACAATCAGGCGGTTGTCTTCAAAATCGAATCGCACAACCATCCGTCAGCGATTGA
GCCTTATCAGGGAGCTGCAACGGGTGTGGGCGGCATCATCCGCGACGTCTTTTCAATGGGCGCGCGTCCCATCGCTGTTT
TGAACTCTCTCCGGTTTGGCGAACTCACTTCACCGCGTGTGAAGTACTTGTTTGAAGAAGTAGTCGCGGGCATTGCCGGA
TACGGAAACTGCATCGGCATTCCGACCGTTGGCGGGGAAGTTCAGTTTGACGGCTGCTATGAAGGCAATCCGCTTGTCAA
CGCGATGTGTGTCGGTTTAATCAACCATGAAGATATTAAAAAAGGGCAGGCGAAAGGCGTCGGCAATACCGTCATGTACG
TCGGCGCGAAAACGGGGCGCGACGGCATCCACGGCGCAACGTTCGCCTCAGAGGAAATGTCTGACCAATCAGAAGAAAAG
CGCTCGGCCGTTCAAGTCGGCGATCCGTTCATGGAGAAGCTGCTTCTTGAAGCGTGTCTGGAAGTCATCAAATCTGACGC
TTTGGTCGGTATTCAGGACATGGGTGCGGCAGGCCTGACAAGTTCAAGCGCGGAAATGGCATCCAAAGCCGGGTCTGGGA
TCGAGATGAACCTTGACTTGATTCCGCAGCGCGAAACAGGCATGACGCCGTACGAAATGATGCTTTCGGAATCCCAGGAG
CGCATGCTTTTGGTTATCGAACGCGGCCGCGAACAGGAAATCATCGATATTTTTGACAAGTACGATCTTGAAGCCGTTGC
TGTCGGCCATGTGACTGATGACAAGATGCTGCGCCTTTTCCATAACGGAGAAATGGTTGCCGAGCTTCCGGTCGATGCTC
TTGCAGAGGAAGCGCCTGTTTACCATAAGCCGTCAAAAGTACCGGATTATTACAAAGAGTTCCTTGAAACAGACGTCCCT
GCACCAAAAGTCGAAGATGCGAAAGAAACGCTTCTCGAGCTGCTAAAGCAGCCGACCATTGCGAGCAAAGAATGGGTTTA
TGACCAATATGACTACATGGTCAGGACGAACACGGTTGTCGCACCGGGCTCTGATGCAGCCGTCCTCAGGATTCGCGGCA
CGAAAAAAGCGCTCGCCATGACAACGGACTGCAATGCCCGCTACTTGTACCTTGATCCGGAAACAGGCGGGAAAATCGCC
GTCGCAGAAGCGGCCCGCAATATCGTCTGCTCCGGAGCAGAACCGCTTGCCGTTACGGATAACCTCAACTTTGGAAATCC
GGAAAAGCCGGAGATCTTCTGGCAGATCGAAAAAGCGGCAGACGGGATCAGCGAGGCGTGCAACGTGCTCAGCACACCGG
TCATCGGCGGAAACGTCTCTCTCTACAACGAATCAAACGGAAGCGCGATCTACCCGACGCCTGTCATCGGAATGGTCGGA
CTGATCGAAGATACGGAGCATATTACGACACAGCACTTTAAAGCAGCGGGCGATTTGATTTATGTCATCGGCGAAACATT
CCCTGAGTTCGCCGGAAGCGAGCTGCAAAAACTGACCGAAGGAAAGATTTACGGCAAAGCGCCTGCGATTGACCTGGAAG
TCGAACAATCGCGTCAAAAAGCTCTTCTGAAAGCGATCCGCTCCGGACTCGTTCAATCGGCGCATGACGTCTCAGAAGGC
GGCATCGGCGTGGCGCTGGCGGAAAGCGTTATATCTTCTCAAAGGCTCGGCGCCCATGTGACGCTTGCAGGCGAACCTGC
ATTGTTATTCAGCGAAACACAATCACGGTTTATCGTCTCTGTGAAAAAAGACCATCAAGAAGCGTTCGAAAAGCTTGTCA
AAGACGCCGATCTAATCGGTGAAGTAACGTCAGACAGCGTGCTGGCTGTTCAAAGCCAGGAAGGACAACAATGGATTCAT
GCGCAGACAGAAGAGCTCGAAAGCGCATGGAAAGGAGCTATCCCATGCTTGCTGAAATCAAAGGCTTAA

Upstream 100 bases:

>100_bases
GGCATGATGCCTCACCCAGAACGCGCAGTCGATTCTCTGCTCGGAAGCGCCGACGGTCTTAAACTGTTTCAATCTATCGT
GAAAAATTGGAGGGAAACTC

Downstream 100 bases:

>100_bases
ATGAAGAATGCGGCGTATTTGGGATTTGGGGGCATGAAGAAGCACCGCAAATTACGTACTACGGCCTTCACAGCCTTCAG
CACAGAGGCCAGGAGGGCGC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSLLLEPSQEQIKEEKLYQQMGVSDDEFAMIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILKKFPTKGERVLQGPGE
GAGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG
YGNCIGIPTVGGEVQFDGCYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDQSEEK
RSAVQVGDPFMEKLLLEACLEVIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTPYEMMLSESQE
RMLLVIERGREQEIIDIFDKYDLEAVAVGHVTDDKMLRLFHNGEMVAELPVDALAEEAPVYHKPSKVPDYYKEFLETDVP
APKVEDAKETLLELLKQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVLRIRGTKKALAMTTDCNARYLYLDPETGGKIA
VAEAARNIVCSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGSAIYPTPVIGMVG
LIEDTEHITTQHFKAAGDLIYVIGETFPEFAGSELQKLTEGKIYGKAPAIDLEVEQSRQKALLKAIRSGLVQSAHDVSEG
GIGVALAESVISSQRLGAHVTLAGEPALLFSETQSRFIVSVKKDHQEAFEKLVKDADLIGEVTSDSVLAVQSQEGQQWIH
AQTEELESAWKGAIPCLLKSKA

Sequences:

>Translated_742_residues
MSLLLEPSQEQIKEEKLYQQMGVSDDEFAMIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILKKFPTKGERVLQGPGE
GAGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG
YGNCIGIPTVGGEVQFDGCYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDQSEEK
RSAVQVGDPFMEKLLLEACLEVIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTPYEMMLSESQE
RMLLVIERGREQEIIDIFDKYDLEAVAVGHVTDDKMLRLFHNGEMVAELPVDALAEEAPVYHKPSKVPDYYKEFLETDVP
APKVEDAKETLLELLKQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVLRIRGTKKALAMTTDCNARYLYLDPETGGKIA
VAEAARNIVCSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGSAIYPTPVIGMVG
LIEDTEHITTQHFKAAGDLIYVIGETFPEFAGSELQKLTEGKIYGKAPAIDLEVEQSRQKALLKAIRSGLVQSAHDVSEG
GIGVALAESVISSQRLGAHVTLAGEPALLFSETQSRFIVSVKKDHQEAFEKLVKDADLIGEVTSDSVLAVQSQEGQQWIH
AQTEELESAWKGAIPCLLKSKA
>Mature_741_residues
SLLLEPSQEQIKEEKLYQQMGVSDDEFAMIESILGRLPNYTEIGIFSVMWSEHCSYKNSKPILKKFPTKGERVLQGPGEG
AGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAGY
GNCIGIPTVGGEVQFDGCYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDQSEEKR
SAVQVGDPFMEKLLLEACLEVIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTPYEMMLSESQER
MLLVIERGREQEIIDIFDKYDLEAVAVGHVTDDKMLRLFHNGEMVAELPVDALAEEAPVYHKPSKVPDYYKEFLETDVPA
PKVEDAKETLLELLKQPTIASKEWVYDQYDYMVRTNTVVAPGSDAAVLRIRGTKKALAMTTDCNARYLYLDPETGGKIAV
AEAARNIVCSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGSAIYPTPVIGMVGL
IEDTEHITTQHFKAAGDLIYVIGETFPEFAGSELQKLTEGKIYGKAPAIDLEVEQSRQKALLKAIRSGLVQSAHDVSEGG
IGVALAESVISSQRLGAHVTLAGEPALLFSETQSRFIVSVKKDHQEAFEKLVKDADLIGEVTSDSVLAVQSQEGQQWIHA
QTEELESAWKGAIPCLLKSKA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=690, Percent_Identity=24.6376811594203, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI48994899, Length=799, Percent_Identity=24.6558197747184, Blast_Score=131, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553022, Length=449, Percent_Identity=23.6080178173719, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=838, Percent_Identity=22.4343675417661, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_BACLD (Q65MS8)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_077923.1
- RefSeq:   YP_090329.1
- ProteinModelPortal:   Q65MS8
- SMR:   Q65MS8
- STRING:   Q65MS8
- EnsemblBacteria:   EBBACT00000057918
- EnsemblBacteria:   EBBACT00000059716
- GeneID:   3031158
- GeneID:   3099282
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00699
- KEGG:   bli:BL01482
- NMPDR:   fig|279010.5.peg.1007
- eggNOG:   COG0046
- GeneTree:   EBGT00050000002932
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   BLIC279010-1:BLI00699-MONOMER
- BioCyc:   BLIC279010:BL01482-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80420; Mature: 80289

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLLEPSQEQIKEEKLYQQMGVSDDEFAMIESILGRLPNYTEIGIFSVMWSEHCSYKNS
CCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
KPILKKFPTKGERVLQGPGEGAGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCCEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDGCY
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDQSEEK
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RSAVQVGDPFMEKLLLEACLEVIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDL
HHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
IPQRETGMTPYEMMLSESQERMLLVIERGREQEIIDIFDKYDLEAVAVGHVTDDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHH
HNGEMVAELPVDALAEEAPVYHKPSKVPDYYKEFLETDVPAPKVEDAKETLLELLKQPTI
HCCCEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
ASKEWVYDQYDYMVRTNTVVAPGSDAAVLRIRGTKKALAMTTDCNARYLYLDPETGGKIA
CCHHHCHHCCCEEEEECEEEECCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEE
VAEAARNIVCSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVS
EEHHHHHEEECCCCCEEEECCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHCCCEECCCEE
LYNESNGSAIYPTPVIGMVGLIEDTEHITTQHFKAAGDLIYVIGETFPEFAGSELQKLTE
EEECCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHCCHHHHHHHC
GKIYGKAPAIDLEVEQSRQKALLKAIRSGLVQSAHDVSEGGIGVALAESVISSQRLGAHV
CCEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEE
TLAGEPALLFSETQSRFIVSVKKDHQEAFEKLVKDADLIGEVTSDSVLAVQSQEGQQWIH
EECCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AQTEELESAWKGAIPCLLKSKA
HHHHHHHHHHCCCCCHHCCCCC
>Mature Secondary Structure 
SLLLEPSQEQIKEEKLYQQMGVSDDEFAMIESILGRLPNYTEIGIFSVMWSEHCSYKNS
CCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCC
KPILKKFPTKGERVLQGPGEGAGIVDIGDNQAVVFKIESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCCCEECCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDGCY
HHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKTGRDGIHGATFASEEMSDQSEEK
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RSAVQVGDPFMEKLLLEACLEVIKSDALVGIQDMGAAGLTSSSAEMASKAGSGIEMNLDL
HHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
IPQRETGMTPYEMMLSESQERMLLVIERGREQEIIDIFDKYDLEAVAVGHVTDDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHH
HNGEMVAELPVDALAEEAPVYHKPSKVPDYYKEFLETDVPAPKVEDAKETLLELLKQPTI
HCCCEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
ASKEWVYDQYDYMVRTNTVVAPGSDAAVLRIRGTKKALAMTTDCNARYLYLDPETGGKIA
CCHHHCHHCCCEEEEECEEEECCCCEEEEEEECCCCEEEEEECCCEEEEEECCCCCCEEE
VAEAARNIVCSGAEPLAVTDNLNFGNPEKPEIFWQIEKAADGISEACNVLSTPVIGGNVS
EEHHHHHEEECCCCCEEEECCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHCCCEECCCEE
LYNESNGSAIYPTPVIGMVGLIEDTEHITTQHFKAAGDLIYVIGETFPEFAGSELQKLTE
EEECCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHCCHHHHHHHC
GKIYGKAPAIDLEVEQSRQKALLKAIRSGLVQSAHDVSEGGIGVALAESVISSQRLGAHV
CCEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEE
TLAGEPALLFSETQSRFIVSVKKDHQEAFEKLVKDADLIGEVTSDSVLAVQSQEGQQWIH
EECCCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
AQTEELESAWKGAIPCLLKSKA
HHHHHHHHHHCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA