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The map label for this gene is malL [H]

Identifier: 52784466

GI number: 52784466

Start: 668612

End: 670318

Strand: Direct

Name: malL [H]

Synonym: BLi00664

Alternate gene names: 52784466

Gene position: 668612-670318 (Clockwise)

Preceding gene: 52784465

Following gene: 52784467

Centisome position: 15.83

GC content: 47.63

Gene sequence:

>1707_bases
ATGAGCCAATGGTGGAAAGAGGCAGTCGTGTATCAAATTTACCCGCGGAGTTTTTATGATTCCAACGGAGACGGCTTCGG
TGATTTGCAGGGGGTGATTCAAAAGCTCGATTACATCAAAAGCCTTGGAGCCGATGTCATATGGCTGTGTCCTGTGTTTG
ATTCCCCGCAGGATGACAACGGCTACGACATCAGCGACTATAGAAGCATATACGAAAAGTTCGGGACGAACGATGATATG
TTTCAATTGATTGATGAAGTGCATAAACGCGGAATGAAAATCATTATGGATCTTGTCGTGAATCACACGTCTGATGAACA
TGCCTGGTTTGCCGAAAGCCGCAAGTCAAAGGACAATCCTTACCGTGATTATTATTTTTGGAAGGATCCAAAGGCGGACG
GTTCAGAGCCGAACAATTGGGGATCGATCTTTTCAGGGCCGGCATGGACGCTCGATGAGCGGACAGGACAGTATTATCTT
CACTACTTTTCGAAAAAGCAGCCTGACTTAAACTGGGAGAATGAAGCGGTTCGCCGCGAAGTATACGATTTGATGACATT
TTGGATGGACAGAGGCGTGGACGGCTGGCGGATGGACGTGATCGGTTCCATCTCCAAATTCGTCGACTTTCCCGATTATG
AAACAGATGACAGCCGTCCATATGTCGTCGGCCGCTATCATTCGAACGGCCCCCGTCTGCACGAATTTATACAAGAGATG
AACCGGGAAGTGCTGTCCCGTTACGACTGTATGACGGTCGGCGAAGCAAACGGCTCAGATGTTGAAGAAGCGAAAAAATA
CACGGATCCAAGCAGACATGAGCTGAACATGATTTTTACATTTGAACATATGGATATTGATACCAAACAGCATTCTCCGA
ATGGGAAATGGCAGATGAAGCCGTTTGACCCGATCGCTTTAAAAAAGACGATGACGAGGTGGCAGACCGCTTTAATGAAT
GTCGGCTGGAATACGCTTTATTTCGAAAATCATGATCAGCCGAGGGTCATATCCCGCTGGGGCAATGACCGCGAGCTCCG
CAAACAATGCGCCAAAGCATTTGCAACAGTTCTGCACGGCATGAAGGGAACCCCGTTCATTTATCAAGGTGAAGAAATCG
GCATGACAAACAGCGAGATGCCGCTCGAAATGTATGATGATCTCGAAATCAAAAACGCATACCGCGAACTTGTCATTGAA
AACAAAACGATGACAGAGGAAGACTTTCGAAAAGCCGTGGCGAAAAAAGGGCGGGATCATGCGAGAACGCCGATGCAATG
GGATGACGGGAAATACGCGGGCTTTACGGATGGAGAGCCTTGGCTGGCGGTAAATCCCCGCTATCAAGAAATCAATGTGA
AAGAGTCGCTTGCCGATGAAGATTCGATTTTCTATTATTATCAGAAGCTCATCGGGCTGCGCAAACAAAATAAAGTCATC
GTGTACGGAGACTATCGGCTGCTGCTCGAGGAAGATCCGCGAATCTTTGCGTATATCCGCGAATATCGGGGCGAAAAGCT
GTTAGTCGCCGTGAATTTATCAGAAGAAAAGGCGCTGTTTCATGCTTCGCCGGAATTGCTTGAGGACAGATGGGATGTGC
TGTTGTCAAACTACGCCCGAGAGCGGCTTAATATAAGCGGCAGTATCGACATGGAGCCTTATGAAGCTTTCATGATGATC
AGCCGGGCAAAGGATTACACATCATGA

Upstream 100 bases:

>100_bases
ACAGCGTCGTTTTCAGTCTTTTAAAAGGAGAACCGCTTTCTATGACAGTTTATGGAGAACAGATCGCACTGAACGGACGG
TATGAAAGGAGGATGGCCCG

Downstream 100 bases:

>100_bases
AAGCGGTCATTTTTGACTTGGACGGCGTGATCACGGATACGGCCGAGTATCATTATCTCGCATGGAAACATACTGCAGAA
CAAATCGGCATTGAGATTGA

Product: MalL

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase 1; Sucrase-isomaltase 1; Isomaltase 1 [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKSLGADVIWLCPVFDSPQDDNGYDISDYRSIYEKFGTNDDM
FQLIDEVHKRGMKIIMDLVVNHTSDEHAWFAESRKSKDNPYRDYYFWKDPKADGSEPNNWGSIFSGPAWTLDERTGQYYL
HYFSKKQPDLNWENEAVRREVYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEM
NREVLSRYDCMTVGEANGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMKPFDPIALKKTMTRWQTALMN
VGWNTLYFENHDQPRVISRWGNDRELRKQCAKAFATVLHGMKGTPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIE
NKTMTEEDFRKAVAKKGRDHARTPMQWDDGKYAGFTDGEPWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVI
VYGDYRLLLEEDPRIFAYIREYRGEKLLVAVNLSEEKALFHASPELLEDRWDVLLSNYARERLNISGSIDMEPYEAFMMI
SRAKDYTS

Sequences:

>Translated_568_residues
MSQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKSLGADVIWLCPVFDSPQDDNGYDISDYRSIYEKFGTNDDM
FQLIDEVHKRGMKIIMDLVVNHTSDEHAWFAESRKSKDNPYRDYYFWKDPKADGSEPNNWGSIFSGPAWTLDERTGQYYL
HYFSKKQPDLNWENEAVRREVYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEM
NREVLSRYDCMTVGEANGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMKPFDPIALKKTMTRWQTALMN
VGWNTLYFENHDQPRVISRWGNDRELRKQCAKAFATVLHGMKGTPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIE
NKTMTEEDFRKAVAKKGRDHARTPMQWDDGKYAGFTDGEPWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVI
VYGDYRLLLEEDPRIFAYIREYRGEKLLVAVNLSEEKALFHASPELLEDRWDVLLSNYARERLNISGSIDMEPYEAFMMI
SRAKDYTS
>Mature_567_residues
SQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKSLGADVIWLCPVFDSPQDDNGYDISDYRSIYEKFGTNDDMF
QLIDEVHKRGMKIIMDLVVNHTSDEHAWFAESRKSKDNPYRDYYFWKDPKADGSEPNNWGSIFSGPAWTLDERTGQYYLH
YFSKKQPDLNWENEAVRREVYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEMN
REVLSRYDCMTVGEANGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMKPFDPIALKKTMTRWQTALMNV
GWNTLYFENHDQPRVISRWGNDRELRKQCAKAFATVLHGMKGTPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIEN
KTMTEEDFRKAVAKKGRDHARTPMQWDDGKYAGFTDGEPWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVIV
YGDYRLLLEEDPRIFAYIREYRGEKLLVAVNLSEEKALFHASPELLEDRWDVLLSNYARERLNISGSIDMEPYEAFMMIS
RAKDYTS

Specific function: Hydrolyzes various disaccharides such as sucrose, maltose, and isomaltose with different efficiencies. Also hydrolyzes longer maltodextrins from maltotriose up to maltohexaose, but not maltoheptaose, palatinose, isomaltotriose, or isomaltotetraose [H]

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=540, Percent_Identity=29.0740740740741, Blast_Score=225, Evalue=1e-58,
Organism=Escherichia coli, GI1790687, Length=564, Percent_Identity=45.2127659574468, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1786604, Length=210, Percent_Identity=30.4761904761905, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32565753, Length=565, Percent_Identity=24.4247787610619, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25147709, Length=495, Percent_Identity=24.8484848484848, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321726, Length=594, Percent_Identity=41.2457912457912, Blast_Score=445, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6324416, Length=589, Percent_Identity=40.4074702886248, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322241, Length=589, Percent_Identity=40.2376910016978, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322021, Length=589, Percent_Identity=40.2376910016978, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322245, Length=580, Percent_Identity=39.6551724137931, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321731, Length=549, Percent_Identity=42.8051001821494, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319776, Length=549, Percent_Identity=42.8051001821494, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583745, Length=537, Percent_Identity=34.2644320297952, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI221330053, Length=589, Percent_Identity=33.276740237691, Blast_Score=265, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24583747, Length=547, Percent_Identity=33.45521023766, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24583749, Length=547, Percent_Identity=33.45521023766, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24586587, Length=592, Percent_Identity=32.0945945945946, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24586599, Length=533, Percent_Identity=32.2701688555347, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24586593, Length=592, Percent_Identity=29.8986486486487, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586597, Length=511, Percent_Identity=33.2681017612524, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586591, Length=599, Percent_Identity=30.7178631051753, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24586589, Length=536, Percent_Identity=31.1567164179104, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI45549022, Length=537, Percent_Identity=31.098696461825, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI281360393, Length=536, Percent_Identity=27.0522388059701, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 66990; Mature: 66859

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKSLGADVIWLCPVFDSPQDDN
CCHHHHHCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GYDISDYRSIYEKFGTNDDMFQLIDEVHKRGMKIIMDLVVNHTSDEHAWFAESRKSKDNP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
YRDYYFWKDPKADGSEPNNWGSIFSGPAWTLDERTGQYYLHYFSKKQPDLNWENEAVRRE
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCHHHHHHH
VYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
NREVLSRYDCMTVGEANGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMK
HHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEECC
PFDPIALKKTMTRWQTALMNVGWNTLYFENHDQPRVISRWGNDRELRKQCAKAFATVLHG
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCC
MKGTPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIENKTMTEEDFRKAVAKKGRDH
CCCCCEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
ARTPMQWDDGKYAGFTDGEPWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVI
CCCCCCCCCCCCCCCCCCCCEEEECCCCEECCHHHHHCCCCHHHHHHHHHHCCCCCCEEE
VYGDYRLLLEEDPRIFAYIREYRGEKLLVAVNLSEEKALFHASPELLEDRWDVLLSNYAR
EEECEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHH
ERLNISGSIDMEPYEAFMMISRAKDYTS
HHCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQWWKEAVVYQIYPRSFYDSNGDGFGDLQGVIQKLDYIKSLGADVIWLCPVFDSPQDDN
CHHHHHCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GYDISDYRSIYEKFGTNDDMFQLIDEVHKRGMKIIMDLVVNHTSDEHAWFAESRKSKDNP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
YRDYYFWKDPKADGSEPNNWGSIFSGPAWTLDERTGQYYLHYFSKKQPDLNWENEAVRRE
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCHHHHHHH
VYDLMTFWMDRGVDGWRMDVIGSISKFVDFPDYETDDSRPYVVGRYHSNGPRLHEFIQEM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
NREVLSRYDCMTVGEANGSDVEEAKKYTDPSRHELNMIFTFEHMDIDTKQHSPNGKWQMK
HHHHHHHCCCEEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCEECC
PFDPIALKKTMTRWQTALMNVGWNTLYFENHDQPRVISRWGNDRELRKQCAKAFATVLHG
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCC
MKGTPFIYQGEEIGMTNSEMPLEMYDDLEIKNAYRELVIENKTMTEEDFRKAVAKKGRDH
CCCCCEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
ARTPMQWDDGKYAGFTDGEPWLAVNPRYQEINVKESLADEDSIFYYYQKLIGLRKQNKVI
CCCCCCCCCCCCCCCCCCCCEEEECCCCEECCHHHHHCCCCHHHHHHHHHHCCCCCCEEE
VYGDYRLLLEEDPRIFAYIREYRGEKLLVAVNLSEEKALFHASPELLEDRWDVLLSNYAR
EEECEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHH
ERLNISGSIDMEPYEAFMMISRAKDYTS
HHCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9573215; 10229946 [H]