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The map label for this gene is yvdE [H]

Identifier: 52784459

GI number: 52784459

Start: 659091

End: 660041

Strand: Direct

Name: yvdE [H]

Synonym: BLi00657

Alternate gene names: 52784459

Gene position: 659091-660041 (Clockwise)

Preceding gene: 52784458

Following gene: 52784460

Centisome position: 15.61

GC content: 47.95

Gene sequence:

>951_bases
ATGGCAACGTTATCTGATGTAGCAAAGAAAGCAAATGTGTCGAAAATGACGGTATCGCGGGTGATCAATCATCCTGAGAC
TGTGACGGATGAATTGAAAAAGCTTGTTCATTCCGCAATGAAGGAGCTCAATTATATACCGAACTATGCAGCAAGAGCGC
TCGTTCAAAACAGAACACAGGTCGTCAAGCTGCTCATACTGGAAGAAATGGATACAACAGAACCTTATTATATGAATCTG
TTAACGGGAATCAGCCGCGAGCTGGACCGTCATCATTATGCTTTGCAGCTTGTCACAAGGAAATCTCTCAATATCGGCCA
GTGCGACGGCATTATTGCGACGGGGTTGAGAAAAGCCGATTTTGAAGGGCTCATCAAGGTTTTTGAAAAGCCTGTCGTTG
TATTCGGGCAAAATGAAATGGGCTACGATTTTATTGATGTTAACAATGAAAAAGGAACCTATATGGCAACACGTCACGTC
ATTGGTCTGGGCGTCCGCAATGTCGTCTTTTTTGGGATCGATTTGGATGAGCCCTTTGAACGGTCAAGGGAAAAAGGCTA
CCTTCAGGCGATGGAAGGCAGTCTGAAAAAAGCAGCGATTTTCCGGATGGAAAACAGTTCAAAAAAAAGTGAAGCACGCG
CGCGGGAAGTGCTTGCATCCTTTGACGCACCTGCAGCGGTTGTTTGCGCTTCGGACCGAATCGCGCTCGGGGTTATCCGC
GCGGTGCAATCGCTTGGTAAAAGAATTCCGGAAGATGTCGCGGTCACCGGCTATGACGGGGTGTTTCTCGACCGGATCGC
TTCGCCTCGCCTGACAACCGTCAGACAGCCTGTTGTTGAAATGGGAGAGGCTTGCGCGAGAATCCTGCTGAAAAAAATCA
ATGAAGACGGAGCGCCGCAAGGCAATCAATTTTTTGAGCCGGAGCTTATTGTCCGCGAATCGACTTTGTAG

Upstream 100 bases:

>100_bases
TTTCTTTGATTACATTTTATAATTAATTTTAACAAAGTGTCATCAGCCCTCAGGAAGGACTTGCTGACAGTTTGAATCGC
ATAGGTAAGGCGGGGATGAA

Downstream 100 bases:

>100_bases
GGTGTCTCATTCTGTTACCGTTAACAGCTGAAAATGATTGTTCCTGTTACCGCCGTCATGATAATTTCAGAATAAAAGCC
GGTTTATCACAGCCGGACAA

Product: YvdE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELNYIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNL
LTGISRELDRHHYALQLVTRKSLNIGQCDGIIATGLRKADFEGLIKVFEKPVVVFGQNEMGYDFIDVNNEKGTYMATRHV
IGLGVRNVVFFGIDLDEPFERSREKGYLQAMEGSLKKAAIFRMENSSKKSEARAREVLASFDAPAAVVCASDRIALGVIR
AVQSLGKRIPEDVAVTGYDGVFLDRIASPRLTTVRQPVVEMGEACARILLKKINEDGAPQGNQFFEPELIVRESTL

Sequences:

>Translated_316_residues
MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELNYIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNL
LTGISRELDRHHYALQLVTRKSLNIGQCDGIIATGLRKADFEGLIKVFEKPVVVFGQNEMGYDFIDVNNEKGTYMATRHV
IGLGVRNVVFFGIDLDEPFERSREKGYLQAMEGSLKKAAIFRMENSSKKSEARAREVLASFDAPAAVVCASDRIALGVIR
AVQSLGKRIPEDVAVTGYDGVFLDRIASPRLTTVRQPVVEMGEACARILLKKINEDGAPQGNQFFEPELIVRESTL
>Mature_315_residues
ATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELNYIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLL
TGISRELDRHHYALQLVTRKSLNIGQCDGIIATGLRKADFEGLIKVFEKPVVVFGQNEMGYDFIDVNNEKGTYMATRHVI
GLGVRNVVFFGIDLDEPFERSREKGYLQAMEGSLKKAAIFRMENSSKKSEARAREVLASFDAPAAVVCASDRIALGVIRA
VQSLGKRIPEDVAVTGYDGVFLDRIASPRLTTVRQPVVEMGEACARILLKKINEDGAPQGNQFFEPELIVRESTL

Specific function: Repressor That Binds To The Purf Operator And Coregulates Other Genes For De Novo Purine Nucleotide Synthesis. It Is Involved In Regulation Of Purb, Purc, Purek, Purhd, Purl, Purmn And Guaba Expression. Binds Hypoxanthine And Guanine As Inducers. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=342, Percent_Identity=32.7485380116959, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1790194, Length=340, Percent_Identity=30.2941176470588, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=29.3413173652695, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790369, Length=331, Percent_Identity=24.773413897281, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994940, Length=313, Percent_Identity=29.3929712460064, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788474, Length=340, Percent_Identity=25.5882352941176, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787580, Length=318, Percent_Identity=25.1572327044025, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789068, Length=336, Percent_Identity=26.4880952380952, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=25.3776435045317, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789456, Length=330, Percent_Identity=28.1818181818182, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790715, Length=323, Percent_Identity=26.0061919504644, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787906, Length=342, Percent_Identity=25.1461988304094, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35223; Mature: 35092

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELNYIPNYAARALVQNRTQ
CCCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVKLLILEEMDTTEPYYMNLLTGISRELDRHHYALQLVTRKSLNIGQCDGIIATGLRKAD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHH
FEGLIKVFEKPVVVFGQNEMGYDFIDVNNEKGTYMATRHVIGLGVRNVVFFGIDLDEPFE
HHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCHHHEEEEECCCCCHHH
RSREKGYLQAMEGSLKKAAIFRMENSSKKSEARAREVLASFDAPAAVVCASDRIALGVIR
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
AVQSLGKRIPEDVAVTGYDGVFLDRIASPRLTTVRQPVVEMGEACARILLKKINEDGAPQ
HHHHHHHHCCCCCEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNQFFEPELIVRESTL
CCCCCCCCEEEECCCC
>Mature Secondary Structure 
ATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELNYIPNYAARALVQNRTQ
CCHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VVKLLILEEMDTTEPYYMNLLTGISRELDRHHYALQLVTRKSLNIGQCDGIIATGLRKAD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCHHH
FEGLIKVFEKPVVVFGQNEMGYDFIDVNNEKGTYMATRHVIGLGVRNVVFFGIDLDEPFE
HHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCHHHEEEEECCCCCHHH
RSREKGYLQAMEGSLKKAAIFRMENSSKKSEARAREVLASFDAPAAVVCASDRIALGVIR
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHH
AVQSLGKRIPEDVAVTGYDGVFLDRIASPRLTTVRQPVVEMGEACARILLKKINEDGAPQ
HHHHHHHHCCCCCEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GNQFFEPELIVRESTL
CCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]