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The map label for this gene is groEL [H]

Identifier: 52784430

GI number: 52784430

Start: 626726

End: 628360

Strand: Direct

Name: groEL [H]

Synonym: BLi00624

Alternate gene names: 52784430

Gene position: 626726-628360 (Clockwise)

Preceding gene: 52784429

Following gene: 52784432

Centisome position: 14.84

GC content: 48.69

Gene sequence:

>1635_bases
ATGGCAAAAGATATTAAGTTTAGCGAAGAAGCCCGCCGTTCAATGCTGCGCGGTGTAGATGCATTGGCGGATGCTGTAAA
GGTAACTTTGGGACCTAAAGGACGCAACGTCGTTCTTGAGAAAAAATTCGGTTCTCCATTAATCACAAACGACGGTGTAA
CCATCGCGAAAGAAATCGAGCTTGAAGACGCGTTCGAAAACATGGGCGCAAAGCTTGTTGCTGAAGTTGCGAGCAAAACA
AACGATGTTGCCGGTGACGGTACAACAACAGCGACAGTTCTAGCTCAGGCGATGATTCGCGAAGGTCTTAAAAACGTAAC
TGCCGGCGCTAACCCTGTAGGCGTGCGCAAAGGTATCGAGCAGGCTGTGGCTGTAGCTGTTGAAAGCCTGAAAGAAATCT
CTAAACCAATTGAAGGCAAAGAATCAATCGCACAAGTTGCTTCAATCTCCGCTGCAGACGAAGAAGTCGGAAGCCTGATC
GCTGAAGCAATGGAGCGCGTCGGCAACGACGGTGTTATCACGATCGAAGAATCCAAAGGATTCACAACAGAGCTTGAAGT
GGTTGAAGGTATGCAGTTCGACCGCGGATATGCGTCTCCTTACATGGTGACGGATTCCGATAAGATGGAAGCGGTTCTTG
AGAATCCGTACATCTTAGTAACAGACAAAAAAATCACAAACATTCAAGAAATCCTGCCGGTGCTTGAGCAAGTCGTGCAA
CAAGGCAAACCGTTGCTTCTGATTGCTGAAGACGTTGAAGGTGAAGCTCTTGCAACATTGGTTGTCAACAAGCTTCGCGG
AACATTCAACGCAGTGGCTGTTAAAGCGCCTGGATTCGGCGACCGCCGCAAAGCGATGCTCGAAGACATCTCTATCCTGA
CAGGCGCCGAAGTGATCACAGAAGATTTAGGTCTTGACCTTAAATCAACTCAAATCAATCAATTGGGACGCGCTTCTAAA
GTTGTTGTTACAAAAGAAAACACAACAATTGTTGAAGGTGCGGGAGATACAGAGCAAATCGCGGCACGCGTCAACCAAAT
CCGCGCTCAAGTTGAAGAAACAACTTCTGAGTTCGATAAAGAAAAATTACAAGAACGCCTTGCTAAGCTTGCAGGCGGCG
TAGCTGTCATCAAAGTCGGAGCTGCGACTGAAACAGAATTGAAAGAACGCAAGCTTCGCATCGAAGACGCCCTGAACTCT
ACTCGCGCTGCGGTAGAAGAAGGAATCGTATCCGGCGGTGGTACAGCTCTTGTCAATGTTTACAATAAAGTAGCTGCCCT
TGAAGCTGAAGGCGACGAACTGACTGGTATCAACATCGTTCTTCGCGCTCTTGAAGAACCAATCCGTCAAATCGCGCACA
ACGCGGGTCTTGAAGGATCTGTCATCGTTGAGCGCCTGAAAAATGAAGAAATCGGCGTCGGCTACAACGCTGCAACAGGC
GAATGGGTGAACATGATCGACAAAGGTATCGTTGACCCTACAAAAGTAACACGCTCAGCTCTGCAAAACGCAGCATCTGT
AGCGGCTATGTTCCTGACAACTGAAGCAGTTGTTGCCGACAAACCGGAAGAAAACAAAGGCGGCGCAGGAATGCCTGACA
TGGGCGGCATGGGCGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
AAGGTACTGACTACTTAATCTTGCGTGAAAGCGACATTTTAGCTGTTATCGGCTAAGTCATAAATAAAAACGAGACAATT
ATATAGGAGGTTCGAATAAC

Downstream 100 bases:

>100_bases
GCCCAGCGTCCAAACGCTGATATATCAAGGAAAAGAGGCTCTTTTTAGAGCCTCTTTTTTTAAAAAATCACATAAAAATC
ACATTTTTTCGGTTTTAAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKDIKFSEEARRSMLRGVDALADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPVGVRKGIEQAVAVAVESLKEISKPIEGKESIAQVASISAADEEVGSLI
AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLENPYILVTDKKITNIQEILPVLEQVVQ
QGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDISILTGAEVITEDLGLDLKSTQINQLGRASK
VVVTKENTTIVEGAGDTEQIAARVNQIRAQVEETTSEFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVSGGGTALVNVYNKVAALEAEGDELTGINIVLRALEEPIRQIAHNAGLEGSVIVERLKNEEIGVGYNAATG
EWVNMIDKGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGAGMPDMGGMGGMGGMM

Sequences:

>Translated_544_residues
MAKDIKFSEEARRSMLRGVDALADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKT
NDVAGDGTTTATVLAQAMIREGLKNVTAGANPVGVRKGIEQAVAVAVESLKEISKPIEGKESIAQVASISAADEEVGSLI
AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLENPYILVTDKKITNIQEILPVLEQVVQ
QGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDISILTGAEVITEDLGLDLKSTQINQLGRASK
VVVTKENTTIVEGAGDTEQIAARVNQIRAQVEETTSEFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNS
TRAAVEEGIVSGGGTALVNVYNKVAALEAEGDELTGINIVLRALEEPIRQIAHNAGLEGSVIVERLKNEEIGVGYNAATG
EWVNMIDKGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGAGMPDMGGMGGMGGMM
>Mature_543_residues
AKDIKFSEEARRSMLRGVDALADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTN
DVAGDGTTTATVLAQAMIREGLKNVTAGANPVGVRKGIEQAVAVAVESLKEISKPIEGKESIAQVASISAADEEVGSLIA
EAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLENPYILVTDKKITNIQEILPVLEQVVQQ
GKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDISILTGAEVITEDLGLDLKSTQINQLGRASKV
VVTKENTTIVEGAGDTEQIAARVNQIRAQVEETTSEFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNST
RAAVEEGIVSGGGTALVNVYNKVAALEAEGDELTGINIVLRALEEPIRQIAHNAGLEGSVIVERLKNEEIGVGYNAATGE
WVNMIDKGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGAGMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=51.7045454545455, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=51.7045454545455, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI24307939, Length=229, Percent_Identity=27.0742358078603, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI38455427, Length=144, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI5453603, Length=125, Percent_Identity=36, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI63162572, Length=548, Percent_Identity=22.2627737226277, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=62.1673003802281, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=49.4318181818182, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=47.3684210526316, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25144674, Length=577, Percent_Identity=24.263431542461, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25147750, Length=578, Percent_Identity=24.7404844290657, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=52.2900763358779, Blast_Score=517, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6322524, Length=214, Percent_Identity=25.7009345794392, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322350, Length=564, Percent_Identity=21.8085106382979, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=554, Percent_Identity=21.2996389891697, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322049, Length=98, Percent_Identity=40.8163265306122, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320058, Length=179, Percent_Identity=25.6983240223464, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.6129032258064, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.6129032258064, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=48.8593155893536, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=48.8593155893536, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=48.8593155893536, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=43.0127041742287, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=35.1503759398496, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=35.1503759398496, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24583944, Length=532, Percent_Identity=25.7518796992481, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645179, Length=509, Percent_Identity=22.9862475442043, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647245, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18858175, Length=126, Percent_Identity=37.3015873015873, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571140, Length=126, Percent_Identity=37.3015873015873, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652903, Length=130, Percent_Identity=32.3076923076923, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57570; Mature: 57439

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSEEARRSMLRGVDALADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPVGVRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QAVAVAVESLKEISKPIEGKESIAQVASISAADEEVGSLIAEAMERVGNDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLENPYILVTDKKITNIQEILPVLEQVVQ
CCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDISILTGAEVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EDLGLDLKSTQINQLGRASKVVVTKENTTIVEGAGDTEQIAARVNQIRAQVEETTSEFDK
HHHCCCCCHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVSGGGTALVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YNKVAALEAEGDELTGINIVLRALEEPIRQIAHNAGLEGSVIVERLKNEEIGVGYNAATG
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCH
EWVNMIDKGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGAGMPDMGGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
AKDIKFSEEARRSMLRGVDALADAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCEEECCCCEEEECCC
LEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPVGVRKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QAVAVAVESLKEISKPIEGKESIAQVASISAADEEVGSLIAEAMERVGNDGVITIEESKG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
FTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLENPYILVTDKKITNIQEILPVLEQVVQ
CCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
QGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDISILTGAEVIT
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EDLGLDLKSTQINQLGRASKVVVTKENTTIVEGAGDTEQIAARVNQIRAQVEETTSEFDK
HHHCCCCCHHHHHHCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVSGGGTALVNV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YNKVAALEAEGDELTGINIVLRALEEPIRQIAHNAGLEGSVIVERLKNEEIGVGYNAATG
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCH
EWVNMIDKGIVDPTKVTRSALQNAASVAAMFLTTEAVVADKPEENKGGAGMPDMGGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA