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The map label for this gene is ydgK [H]

Identifier: 52784411

GI number: 52784411

Start: 596368

End: 597573

Strand: Direct

Name: ydgK [H]

Synonym: BLi00598

Alternate gene names: 52784411

Gene position: 596368-597573 (Clockwise)

Preceding gene: 52784410

Following gene: 52784413

Centisome position: 14.12

GC content: 50.5

Gene sequence:

>1206_bases
ATGCTTCATAATCCAGTTGGAAAAGAGAGGTTGGCATTGGCTTTTCTGCTCGGAATGCTTGCCATACTTGGACCTCTTAA
TATCGATATGTATTTGCCGAGCTTCCCTGAAATAGCGGATGACCTGGGAGCCGGTGCGTCGCTTGTGCAGCTCAGCTTAA
CGGCTTGCTTGATCGGCCTTACCATCGGCCAGCTCGTGATTGGGCCTGTGAGCGATGCGAAGGGAAGGCGAAAACCTTTA
TTAATTTCGATTTCGCTGTTTGCGCTGTCTTCACTGTTTTGCGCGCTGTCGCCTAATATCGCGACATTAGTGCTTGCCCG
TTTTTTACAGGGATTTACCGCTTCGGCTGGAATTGTGCTGTCGCGCGCCATTGTACGGGACGTGTTTACAGGGAGAGAGC
TTTCTAAATTTTTCTCGCTTCTAATGGTTATCACCGCGGTTGCGCCGATGGTCGCGCCGATGACGGGGGGAGCCATCCTG
CTTTTGCCGTTCGCTACTTGGCATACGATTTTTTATACGCTGGCATTGATCGGATTGTTACTAGTACTCGTTATCTCGAT
GAAATTGACTGAAACATTGCCGCCCGAAAAACGGATTCCAAGCTCAATCGGTTCGTCTCTCAAAACGATGGGGAGCTTGT
TGAAGGATCGGTCTTTTATCGGCTATGCGCTGACTGTCGGTTTCATTCACGGAGGCAGCTTTGCCTACGTATCCGGAACG
CCTTTTGTATATCAGGATATCTATGGGGTTTCTCCTCAGGTGTTCAGCGTGCTGTTCGGCATTAACGGCCTCGCCATTAT
TTCGGGAAGCTTTATCATCGGGCGATTCGGGGGAATCATTCATGAGAGGAAGCTCTTGCGGATCGCGGTCATTACCGCTG
TCATCGCGACATCCGTTCTCCTGACGATGACGATTTTGAAAGGACCGCTTGCAGCGATTGTCATTTCAATCTTTATCTAC
ATGATAACCATCGGAATGACGTTGACAAGCACATTTACGCTGGCGATGGAAAACCAGGGGCACCGTGCGGGCAGTGCAAG
CGCAATGCTGGGCATGCTTCCGCTGCTGCTCGGTTCGATCGTTTCGCCTCTCGTTGGAATGAATGAAACAACGGCCGTTC
CAATGGGTGCGATCATGTTCATCACTGCTGTGATCGGCTCTTTCGCTTTTTTTGCTTTAACGCGGGAAAACCAGGGGGAG
CGGTAA

Upstream 100 bases:

>100_bases
CACTGTTCAAAAAATATGGTACAATATACAAATGTTTTGCAGCCTGTAACAATAGAAACAGAGATGTTAACTAGGTTGAT
AGAAAGGTTTTGATGTTTTT

Downstream 100 bases:

>100_bases
AGGTAAAGGACGGAATCACTTGATTCCGTCCTTTTGTTGTTATAGAGGCGCCCGCTGGATGGCGGAGTCTGAGACGTCCG
CGGATTCATTGATAGAAATG

Product: YdgK

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLHNPVGKERLALAFLLGMLAILGPLNIDMYLPSFPEIADDLGAGASLVQLSLTACLIGLTIGQLVIGPVSDAKGRRKPL
LISISLFALSSLFCALSPNIATLVLARFLQGFTASAGIVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL
LLPFATWHTIFYTLALIGLLLVLVISMKLTETLPPEKRIPSSIGSSLKTMGSLLKDRSFIGYALTVGFIHGGSFAYVSGT
PFVYQDIYGVSPQVFSVLFGINGLAIISGSFIIGRFGGIIHERKLLRIAVITAVIATSVLLTMTILKGPLAAIVISIFIY
MITIGMTLTSTFTLAMENQGHRAGSASAMLGMLPLLLGSIVSPLVGMNETTAVPMGAIMFITAVIGSFAFFALTRENQGE
R

Sequences:

>Translated_401_residues
MLHNPVGKERLALAFLLGMLAILGPLNIDMYLPSFPEIADDLGAGASLVQLSLTACLIGLTIGQLVIGPVSDAKGRRKPL
LISISLFALSSLFCALSPNIATLVLARFLQGFTASAGIVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL
LLPFATWHTIFYTLALIGLLLVLVISMKLTETLPPEKRIPSSIGSSLKTMGSLLKDRSFIGYALTVGFIHGGSFAYVSGT
PFVYQDIYGVSPQVFSVLFGINGLAIISGSFIIGRFGGIIHERKLLRIAVITAVIATSVLLTMTILKGPLAAIVISIFIY
MITIGMTLTSTFTLAMENQGHRAGSASAMLGMLPLLLGSIVSPLVGMNETTAVPMGAIMFITAVIGSFAFFALTRENQGE
R
>Mature_401_residues
MLHNPVGKERLALAFLLGMLAILGPLNIDMYLPSFPEIADDLGAGASLVQLSLTACLIGLTIGQLVIGPVSDAKGRRKPL
LISISLFALSSLFCALSPNIATLVLARFLQGFTASAGIVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL
LLPFATWHTIFYTLALIGLLLVLVISMKLTETLPPEKRIPSSIGSSLKTMGSLLKDRSFIGYALTVGFIHGGSFAYVSGT
PFVYQDIYGVSPQVFSVLFGINGLAIISGSFIIGRFGGIIHERKLLRIAVITAVIATSVLLTMTILKGPLAAIVISIFIY
MITIGMTLTSTFTLAMENQGHRAGSASAMLGMLPLLLGSIVSPLVGMNETTAVPMGAIMFITAVIGSFAFFALTRENQGE
R

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=369, Percent_Identity=31.4363143631436, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI48994889, Length=265, Percent_Identity=34.3396226415094, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790146, Length=268, Percent_Identity=28.7313432835821, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787065, Length=377, Percent_Identity=26.790450928382, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790794, Length=346, Percent_Identity=24.2774566473988, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082312, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081983, Length=210, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325414, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321577, Length=109, Percent_Identity=33.9449541284404, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=171, Percent_Identity=27.4853801169591, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42461; Mature: 42461

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHNPVGKERLALAFLLGMLAILGPLNIDMYLPSFPEIADDLGAGASLVQLSLTACLIGL
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHH
TIGQLVIGPVSDAKGRRKPLLISISLFALSSLFCALSPNIATLVLARFLQGFTASAGIVL
HHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
SRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAILLLPFATWHTIFYTLALIGLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LVLVISMKLTETLPPEKRIPSSIGSSLKTMGSLLKDRSFIGYALTVGFIHGGSFAYVSGT
HHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCEEEECCC
PFVYQDIYGVSPQVFSVLFGINGLAIISGSFIIGRFGGIIHERKLLRIAVITAVIATSVL
CHHHHHHHCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTMTILKGPLAAIVISIFIYMITIGMTLTSTFTLAMENQGHRAGSASAMLGMLPLLLGSI
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHH
VSPLVGMNETTAVPMGAIMFITAVIGSFAFFALTRENQGER
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MLHNPVGKERLALAFLLGMLAILGPLNIDMYLPSFPEIADDLGAGASLVQLSLTACLIGL
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHH
TIGQLVIGPVSDAKGRRKPLLISISLFALSSLFCALSPNIATLVLARFLQGFTASAGIVL
HHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHH
SRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAILLLPFATWHTIFYTLALIGLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LVLVISMKLTETLPPEKRIPSSIGSSLKTMGSLLKDRSFIGYALTVGFIHGGSFAYVSGT
HHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEEEECCCEEEECCC
PFVYQDIYGVSPQVFSVLFGINGLAIISGSFIIGRFGGIIHERKLLRIAVITAVIATSVL
CHHHHHHHCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTMTILKGPLAAIVISIFIYMITIGMTLTSTFTLAMENQGHRAGSASAMLGMLPLLLGSI
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHH
VSPLVGMNETTAVPMGAIMFITAVIGSFAFFALTRENQGER
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]