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The map label for this gene is gltT [H]

Identifier: 52784356

GI number: 52784356

Start: 542521

End: 543765

Strand: Direct

Name: gltT [H]

Synonym: BLi00536

Alternate gene names: 52784356

Gene position: 542521-543765 (Clockwise)

Preceding gene: 52784355

Following gene: 52784357

Centisome position: 12.85

GC content: 47.95

Gene sequence:

>1245_bases
ATGAAGTTAGCAACAAAAATTATTATCGCTCTATTGCTCGGTGCAGTCGTCGGTATTATACTGAACGTCACTTCACCGGA
TTTATTCAGCAAGCTTAATACATTTTTATTCGGGCCGCTCGGCACGATCTTCCTTAACTTAATCAAGATGCTCGTTGTAC
CGATTGTTTTCTTTTCTCTGACTTTAGGGGTAGCAGGACTTGGAGATCCAAAGAAATTGGGCAGAATCGGTGCCAAAACG
ATTTCTTTCTTTTTAATAACTACTGCAATTGCCATTATTATCGGACTTGTTTTAGCGTTGGTCATCAAACCTGGAACGAT
CGGAACATATGATACAAGCGCTGCGGAATATTCAGCCCAGAAAGCGCCAAGCATTTCTGACACGCTTTTGAATATCATTC
CGACAAACCCGGTTCAGGCAATGGCTGAAGGAAATATGCTGCAAATCATTGCTTTCTCCATTTTGGTCGGTCTCGGAATT
ACGATGCTGGGCAAAAAAGCGGACGCTCTTCTCAAAGTGGTTGAACAGGGTAACGATCTGATGATGTACCTGGTCAATCT
TGTCATGAAGTTCGCGCCGTACGGTACGTTCGGCTTGATTGCCGGGGCAATCGGAAGCCAGGGCTGGGACGCCATTAAAG
CAATGGGGCTTTATATGATCGTCGTTATTCTGGCGCTGTTCATTCATACCATCGTCACATACGGCGCAGCGATTGCGCTT
CTGGCAAAGCGGAACCCGCTCACATTCTTTAAAGATTTTTCAGAGGTTATGCTTGTTGCCTTCAGTACGTCCAGCAGCAA
CGCGACGCTTCCGGTTTCGATGGATGTCGCTCAAAGAAAGCTGAAAGTTCCAGAGCCGATCTCAAGCTTTGTCCAGCCGC
TCGGAGCTACGATCAACATGGACGGAACGGCGATCATGCAAGGGGTGGCAACAGTCTTTATCGCTCAGGTGTACGGCAAT
GACCTGTCGCTCACACAGCTGTTGATGGTTGTTCTCACGGCAGTGCTTGCCAGCATCGGAACAGCGGGTGTTCCGGGTGT
CGGACTCATTATGCTCGCCATGGTTCTTCAAACAGTTGGCCTTCCAGTTGAGGGAATTGCGCTAATATTGGGAATTGACC
GACTTCTGGACATGATTCGTACGGCTGTCAATACAACAGGCGATGCAGCATGTGCGGTCATCGTCACCGAGACGGAAAAG
AAACACGGCAAAATCGAAGCCCCTCATAGTGAAGTGTCCGTGTAA

Upstream 100 bases:

>100_bases
ACCTCATCAACGTGAAGAGAGTCATGTGGAACCAATTTTAATGGTAAAAGCCCGTGGGAGATCTCTCATGGGCTTTTTTT
AGAAAGGGGAGATATGTTAT

Downstream 100 bases:

>100_bases
CTTAAGAAATGATATAATCAAACAGTGCCTTTTCGGCACTGTTTATTTTTTTGGAAAGAGGAGGGGGCTATGACAAAGCA
GCCTGTTTTACATATAGAAA

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKLATKIIIALLLGAVVGIILNVTSPDLFSKLNTFLFGPLGTIFLNLIKMLVVPIVFFSLTLGVAGLGDPKKLGRIGAKT
ISFFLITTAIAIIIGLVLALVIKPGTIGTYDTSAAEYSAQKAPSISDTLLNIIPTNPVQAMAEGNMLQIIAFSILVGLGI
TMLGKKADALLKVVEQGNDLMMYLVNLVMKFAPYGTFGLIAGAIGSQGWDAIKAMGLYMIVVILALFIHTIVTYGAAIAL
LAKRNPLTFFKDFSEVMLVAFSTSSSNATLPVSMDVAQRKLKVPEPISSFVQPLGATINMDGTAIMQGVATVFIAQVYGN
DLSLTQLLMVVLTAVLASIGTAGVPGVGLIMLAMVLQTVGLPVEGIALILGIDRLLDMIRTAVNTTGDAACAVIVTETEK
KHGKIEAPHSEVSV

Sequences:

>Translated_414_residues
MKLATKIIIALLLGAVVGIILNVTSPDLFSKLNTFLFGPLGTIFLNLIKMLVVPIVFFSLTLGVAGLGDPKKLGRIGAKT
ISFFLITTAIAIIIGLVLALVIKPGTIGTYDTSAAEYSAQKAPSISDTLLNIIPTNPVQAMAEGNMLQIIAFSILVGLGI
TMLGKKADALLKVVEQGNDLMMYLVNLVMKFAPYGTFGLIAGAIGSQGWDAIKAMGLYMIVVILALFIHTIVTYGAAIAL
LAKRNPLTFFKDFSEVMLVAFSTSSSNATLPVSMDVAQRKLKVPEPISSFVQPLGATINMDGTAIMQGVATVFIAQVYGN
DLSLTQLLMVVLTAVLASIGTAGVPGVGLIMLAMVLQTVGLPVEGIALILGIDRLLDMIRTAVNTTGDAACAVIVTETEK
KHGKIEAPHSEVSV
>Mature_414_residues
MKLATKIIIALLLGAVVGIILNVTSPDLFSKLNTFLFGPLGTIFLNLIKMLVVPIVFFSLTLGVAGLGDPKKLGRIGAKT
ISFFLITTAIAIIIGLVLALVIKPGTIGTYDTSAAEYSAQKAPSISDTLLNIIPTNPVQAMAEGNMLQIIAFSILVGLGI
TMLGKKADALLKVVEQGNDLMMYLVNLVMKFAPYGTFGLIAGAIGSQGWDAIKAMGLYMIVVILALFIHTIVTYGAAIAL
LAKRNPLTFFKDFSEVMLVAFSTSSSNATLPVSMDVAQRKLKVPEPISSFVQPLGATINMDGTAIMQGVATVFIAQVYGN
DLSLTQLLMVVLTAVLASIGTAGVPGVGLIMLAMVLQTVGLPVEGIALILGIDRLLDMIRTAVNTTGDAACAVIVTETEK
KHGKIEAPHSEVSV

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=460, Percent_Identity=33.4782608695652, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI194239697, Length=462, Percent_Identity=29.004329004329, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI169790839, Length=470, Percent_Identity=30, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI5032093, Length=418, Percent_Identity=34.4497607655502, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI21314632, Length=425, Percent_Identity=31.0588235294118, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4827012, Length=291, Percent_Identity=35.7388316151203, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=35.6115107913669, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=35.3159851301115, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI40254478, Length=269, Percent_Identity=36.4312267657993, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI262359914, Length=385, Percent_Identity=27.5324675324675, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI301601644, Length=169, Percent_Identity=39.6449704142012, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=38.2075471698113, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789947, Length=400, Percent_Identity=33, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1788024, Length=388, Percent_Identity=27.5773195876289, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789473, Length=368, Percent_Identity=27.1739130434783, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=457, Percent_Identity=32.6039387308534, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71983099, Length=457, Percent_Identity=32.6039387308534, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71996953, Length=450, Percent_Identity=33.7777777777778, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17537407, Length=445, Percent_Identity=32.8089887640449, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI193206505, Length=411, Percent_Identity=35.036496350365, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI193206654, Length=417, Percent_Identity=29.0167865707434, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17541374, Length=397, Percent_Identity=31.2342569269521, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=30.787037037037, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=30.787037037037, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=30.787037037037, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281360483, Length=421, Percent_Identity=29.4536817102138, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17137666, Length=421, Percent_Identity=29.4536817102138, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281360481, Length=421, Percent_Identity=29.4536817102138, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43462; Mature: 43462

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]