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The map label for this gene is adk

Identifier: 52783992

GI number: 52783992

Start: 143790

End: 144443

Strand: Direct

Name: adk

Synonym: BLi00154

Alternate gene names: 52783992

Gene position: 143790-144443 (Clockwise)

Preceding gene: 52783991

Following gene: 52783993

Centisome position: 3.41

GC content: 44.65

Gene sequence:

>654_bases
ATGAACTTAGTCTTAATGGGACTGCCTGGAGCCGGTAAAGGGACACAGGCTGAACGGATTGTTGAAGATTTTGGGATACC
TCATATCTCAACAGGAGACATGTTCCGCGCTGCGATGAAAGAAGAAACGGATCTGGGACTCGAAGCCAAATCATACATTG
ATAAAGGTGAGCTTGTTCCGGATGAAGTGACAATTGGTATTGTCAGGGAGAGACTTGGCAAGAATGATTGTGACGGAGGT
TTTCTTCTGGACGGATTTCCGAGAACAGTCGCTCAAGCTGAAGCACTTGAGGAAATTCTTAAAGGACTTGGCAAGTCGAT
TGACCATGTCATCAACATTCAAGTCGATAAAGATGCATTGATGGAACGTCTGACAGGACGCAGAATCTGCAAAAACTGCG
GTGCAACTTATCATTTAGTCTTTAATCCGCCTGCAAAAGAAAATGTATGCGACAAGTGTGGAGGAGAGCTTTATCAGCGT
GAAGACGATAATGAAGCTACCGTATCCACGCGGTTAGAGGTCAACATGAAGCAAACCCAGCCTTTACTCGATTTCTATGA
AGATAAAGGATATCTCGTAAACATTGACGGGCAGAAGCACATCAATGAAGTTTACGCTGATATAAAGGAGCTTCTCGGAG
GCCGGGACAAATGA

Upstream 100 bases:

>100_bases
AAAGCCAGCTGGTAAAACGAAACTATCGTGGATTTATGAAGCACTAGAGGAAATGGGGCGCGCCCATTCCCTCTAAAATA
GAGAGGACGGGGAATCCGAA

Downstream 100 bases:

>100_bases
TTATTTGTAAAACTCCCCGAGAAATCGAAATCATGCGGGAGGCCGGACGAATTGTCGCTTTAACTCATCAGGAGCTAAAA
AAGCACATTAAACCCGGCAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNLVLMGLPGAGKGTQAERIVEDFGIPHISTGDMFRAAMKEETDLGLEAKSYIDKGELVPDEVTIGIVRERLGKNDCDGG
FLLDGFPRTVAQAEALEEILKGLGKSIDHVINIQVDKDALMERLTGRRICKNCGATYHLVFNPPAKENVCDKCGGELYQR
EDDNEATVSTRLEVNMKQTQPLLDFYEDKGYLVNIDGQKHINEVYADIKELLGGRDK

Sequences:

>Translated_217_residues
MNLVLMGLPGAGKGTQAERIVEDFGIPHISTGDMFRAAMKEETDLGLEAKSYIDKGELVPDEVTIGIVRERLGKNDCDGG
FLLDGFPRTVAQAEALEEILKGLGKSIDHVINIQVDKDALMERLTGRRICKNCGATYHLVFNPPAKENVCDKCGGELYQR
EDDNEATVSTRLEVNMKQTQPLLDFYEDKGYLVNIDGQKHINEVYADIKELLGGRDK
>Mature_217_residues
MNLVLMGLPGAGKGTQAERIVEDFGIPHISTGDMFRAAMKEETDLGLEAKSYIDKGELVPDEVTIGIVRERLGKNDCDGG
FLLDGFPRTVAQAEALEEILKGLGKSIDHVINIQVDKDALMERLTGRRICKNCGATYHLVFNPPAKENVCDKCGGELYQR
EDDNEATVSTRLEVNMKQTQPLLDFYEDKGYLVNIDGQKHINEVYADIKELLGGRDK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=41.4634146341463, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=41.4634146341463, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=40.0943396226415, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=35.8139534883721, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=35.8139534883721, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=35.8139534883721, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=35.8139534883721, Blast_Score=140, Evalue=8e-34,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=29.4685990338164, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=27.9816513761468, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=27.4038461538462, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=30.4761904761905, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=30.4761904761905, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=45.4128440366972, Blast_Score=195, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=38.4976525821596, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=31.0679611650485, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=28.6384976525822, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=217, Percent_Identity=28.110599078341, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=217, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=43.7209302325581, Blast_Score=185, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=37.2448979591837, Blast_Score=135, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=26.6355140186916, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=41.5094339622642, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737899, Length=212, Percent_Identity=36.3207547169811, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24645822, Length=212, Percent_Identity=36.3207547169811, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=23.6714975845411, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=23.6714975845411, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BACLD (P35140)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- EMBL:   X70087
- PIR:   S34405
- RefSeq:   YP_077421.1
- RefSeq:   YP_089821.1
- ProteinModelPortal:   P35140
- SMR:   P35140
- STRING:   P35140
- EnsemblBacteria:   EBBACT00000055194
- EnsemblBacteria:   EBBACT00000059886
- GeneID:   3029349
- GeneID:   3097710
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00154
- KEGG:   bli:BL01030
- NMPDR:   fig|279010.5.peg.1613
- eggNOG:   COG0563
- GeneTree:   EBGT00050000002446
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   BLIC279010-1:BLI00154-MONOMER
- BioCyc:   BLIC279010:BL01030-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR013137
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; PF08271 TFIIB_Zn_Ribbon

EC number: =2.7.4.3

Molecular weight: Translated: 24045; Mature: 24045

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVLMGLPGAGKGTQAERIVEDFGIPHISTGDMFRAAMKEETDLGLEAKSYIDKGELVP
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
DEVTIGIVRERLGKNDCDGGFLLDGFPRTVAQAEALEEILKGLGKSIDHVINIQVDKDAL
CHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCHHHHHEEEEEECHHHH
MERLTGRRICKNCGATYHLVFNPPAKENVCDKCGGELYQREDDNEATVSTRLEVNMKQTQ
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHCCCCCCCEEEEEEEECHHHHH
PLLDFYEDKGYLVNIDGQKHINEVYADIKELLGGRDK
HHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLVLMGLPGAGKGTQAERIVEDFGIPHISTGDMFRAAMKEETDLGLEAKSYIDKGELVP
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
DEVTIGIVRERLGKNDCDGGFLLDGFPRTVAQAEALEEILKGLGKSIDHVINIQVDKDAL
CHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCHHHHHEEEEEECHHHH
MERLTGRRICKNCGATYHLVFNPPAKENVCDKCGGELYQREDDNEATVSTRLEVNMKQTQ
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHHCCCCCCCEEEEEEEECHHHHH
PLLDFYEDKGYLVNIDGQKHINEVYADIKELLGGRDK
HHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435726