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The map label for this gene is yvmA [H]

Identifier: 52144573

GI number: 52144573

Start: 757418

End: 758599

Strand: Reverse

Name: yvmA [H]

Synonym: BCZK0650

Alternate gene names: 52144573

Gene position: 758599-757418 (Counterclockwise)

Preceding gene: 52144570

Following gene: 52144590

Centisome position: 14.31

GC content: 33.5

Gene sequence:

>1182_bases
ATGAAAAAATTTAAACTAACTTTCATTTTATATGTTGTCTGTATTAGTGCCTTACTTGGTTCCTTCGCTCAAAATATTTA
CACACCTATCTTACCGATGATTCAAAATTCTTTTCACACTTCTCTTTATCTTGTAAATGTAACAGTTTCACTTTTCACAT
TTGTTCTTGCGATTATGCAGCTCATATATGGACCTTTAATTGATACAAAAGGAAGAAAGTCTGTCCTTATCCCTAGTTTA
ATTATTAGTACAATTGGTTCAATCGGATGTGCTTTTTCGCCGAACGTTTATTTATTTCTCTTTTTTAGAGCTGTTCAAGC
TATAGGAATAGCGGCTATACCTGTAGTTTCAGCAACGATTATTGGTGATTTGTTTGAAGGAAAAGAACGAGGAGAAGCGA
TGAGCCTGTATCAAATGTTACTTGCTCTCGCACCTGCGATTGGTCCTCTCATAGGTGGTTATCTCGGCAGTATAAATGGC
CACTTATCCGTATTTCTGTTTTTATCTATACTTGGCATTCTCTTATTAATTATAAACATTTCTCTACTTCCAGAAACAAA
ACCAACTGTAATGAAACAACCACAAGCAAAAAAGAATTACTGGCTTATCTTAAAAAATAAAACTGGATATTCTATTACAC
TTATTGGTTTCATTCAATTTTGTATTTACTTTTGCTTTCTCATTTTTTTACCGAGCATTTTAGCAAATTCATTTCATCTA
GCTGCAAGTGAAATTGGTCTTATGTTTGTACCAATGTCTCTTTCTATTATGATAGGAAGTTATTACTACAAGTTTTTGCA
AAAACGACTCACAACAAAGCAAGCTTTATTCATTACGAGTTTCTTCAATATTATATGTGTCGTTTTATTCTCTTTCACAT
ATAGCATCAATATCCCATTCATCATTATCGTTACATCTTTGTACGGTTTTAGTATAGGACTTTCTATGCCAACTCACACT
ACTTTATTAACAGAAGAATTCGTACAAGAACGCGCAACAGCTATCGGTATGTACAACTTCATCCGCTATCTCGGTATGGG
GACTGGACCTATTGTAGGTGGCTTTCTTTTATTTAGTCAAAATTACTTTTGGATTTTCTTCCTAGGTGCAATTATGTTTC
TAATCATAATCTTATATGCGATGAAAATGCTACGCTTCCCCGTCACACAAAAAGTAAAATAG

Upstream 100 bases:

>100_bases
TATACCATTTTAAAACCATTTTTTCATCTTTACAAGTGAGAAAATCATGTTAAAATAAATTTAGTTTCCAAGGAAACAAA
AATACAAGGAGGTTAACAAG

Downstream 100 bases:

>100_bases
AGACCTACAGATGGTCTCTATTTTAAACTCTTTGATCCGCAACGATATGAATATCAATATGTTTCGTTTGTCTCATAATT
TCATTTACAATCGAACCTTT

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKKFKLTFILYVVCISALLGSFAQNIYTPILPMIQNSFHTSLYLVNVTVSLFTFVLAIMQLIYGPLIDTKGRKSVLIPSL
IISTIGSIGCAFSPNVYLFLFFRAVQAIGIAAIPVVSATIIGDLFEGKERGEAMSLYQMLLALAPAIGPLIGGYLGSING
HLSVFLFLSILGILLLIINISLLPETKPTVMKQPQAKKNYWLILKNKTGYSITLIGFIQFCIYFCFLIFLPSILANSFHL
AASEIGLMFVPMSLSIMIGSYYYKFLQKRLTTKQALFITSFFNIICVVLFSFTYSINIPFIIIVTSLYGFSIGLSMPTHT
TLLTEEFVQERATAIGMYNFIRYLGMGTGPIVGGFLLFSQNYFWIFFLGAIMFLIIILYAMKMLRFPVTQKVK

Sequences:

>Translated_393_residues
MKKFKLTFILYVVCISALLGSFAQNIYTPILPMIQNSFHTSLYLVNVTVSLFTFVLAIMQLIYGPLIDTKGRKSVLIPSL
IISTIGSIGCAFSPNVYLFLFFRAVQAIGIAAIPVVSATIIGDLFEGKERGEAMSLYQMLLALAPAIGPLIGGYLGSING
HLSVFLFLSILGILLLIINISLLPETKPTVMKQPQAKKNYWLILKNKTGYSITLIGFIQFCIYFCFLIFLPSILANSFHL
AASEIGLMFVPMSLSIMIGSYYYKFLQKRLTTKQALFITSFFNIICVVLFSFTYSINIPFIIIVTSLYGFSIGLSMPTHT
TLLTEEFVQERATAIGMYNFIRYLGMGTGPIVGGFLLFSQNYFWIFFLGAIMFLIIILYAMKMLRFPVTQKVK
>Mature_393_residues
MKKFKLTFILYVVCISALLGSFAQNIYTPILPMIQNSFHTSLYLVNVTVSLFTFVLAIMQLIYGPLIDTKGRKSVLIPSL
IISTIGSIGCAFSPNVYLFLFFRAVQAIGIAAIPVVSATIIGDLFEGKERGEAMSLYQMLLALAPAIGPLIGGYLGSING
HLSVFLFLSILGILLLIINISLLPETKPTVMKQPQAKKNYWLILKNKTGYSITLIGFIQFCIYFCFLIFLPSILANSFHL
AASEIGLMFVPMSLSIMIGSYYYKFLQKRLTTKQALFITSFFNIICVVLFSFTYSINIPFIIIVTSLYGFSIGLSMPTHT
TLLTEEFVQERATAIGMYNFIRYLGMGTGPIVGGFLLFSQNYFWIFFLGAIMFLIIILYAMKMLRFPVTQKVK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=273, Percent_Identity=29.3040293040293, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082312, Length=358, Percent_Identity=21.7877094972067, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790146, Length=183, Percent_Identity=25.1366120218579, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788509, Length=355, Percent_Identity=23.0985915492958, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322071, Length=292, Percent_Identity=26.3698630136986, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324264, Length=189, Percent_Identity=30.6878306878307, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322070, Length=312, Percent_Identity=25.9615384615385, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319517, Length=186, Percent_Identity=28.494623655914, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319657, Length=164, Percent_Identity=33.5365853658537, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325414, Length=436, Percent_Identity=20.8715596330275, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321577, Length=436, Percent_Identity=20.4128440366972, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43936; Mature: 43936

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFKLTFILYVVCISALLGSFAQNIYTPILPMIQNSFHTSLYLVNVTVSLFTFVLAIMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEHHHHHHHHHHHHHHH
LIYGPLIDTKGRKSVLIPSLIISTIGSIGCAFSPNVYLFLFFRAVQAIGIAAIPVVSATI
HHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IGDLFEGKERGEAMSLYQMLLALAPAIGPLIGGYLGSINGHLSVFLFLSILGILLLIINI
HHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SLLPETKPTVMKQPQAKKNYWLILKNKTGYSITLIGFIQFCIYFCFLIFLPSILANSFHL
HCCCCCCCHHHCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AASEIGLMFVPMSLSIMIGSYYYKFLQKRLTTKQALFITSFFNIICVVLFSFTYSINIPF
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIIVTSLYGFSIGLSMPTHTTLLTEEFVQERATAIGMYNFIRYLGMGTGPIVGGFLLFSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
NYFWIFFLGAIMFLIIILYAMKMLRFPVTQKVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKFKLTFILYVVCISALLGSFAQNIYTPILPMIQNSFHTSLYLVNVTVSLFTFVLAIMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEEHHHHHHHHHHHHHHH
LIYGPLIDTKGRKSVLIPSLIISTIGSIGCAFSPNVYLFLFFRAVQAIGIAAIPVVSATI
HHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IGDLFEGKERGEAMSLYQMLLALAPAIGPLIGGYLGSINGHLSVFLFLSILGILLLIINI
HHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SLLPETKPTVMKQPQAKKNYWLILKNKTGYSITLIGFIQFCIYFCFLIFLPSILANSFHL
HCCCCCCCHHHCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AASEIGLMFVPMSLSIMIGSYYYKFLQKRLTTKQALFITSFFNIICVVLFSFTYSINIPF
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIIVTSLYGFSIGLSMPTHTTLLTEEFVQERATAIGMYNFIRYLGMGTGPIVGGFLLFSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
NYFWIFFLGAIMFLIIILYAMKMLRFPVTQKVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]