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The map label for this gene is prsA [H]

Identifier: 52144166

GI number: 52144166

Start: 1169151

End: 1170008

Strand: Reverse

Name: prsA [H]

Synonym: BCZK1061

Alternate gene names: 52144166

Gene position: 1170008-1169151 (Counterclockwise)

Preceding gene: 52144163

Following gene: 52144167

Centisome position: 22.07

GC content: 33.33

Gene sequence:

>858_bases
ATGAGAGGGAAACACATTTTCATTATTACTGCACTAATAAGTATATTAATGCTAGCTGCTTGCGGGCAAAAAGATAGCTC
AGCTACAGTCGCTACGGCAACAGACTCAACCATTACAAAGAGCGACTTCGAAAAGCAGTTAAAAGATCGTTACGGAAAAG
ACATGCTATACGAAATGATGGCACAAGACGTTATCACGAAAAAATATAAAGTATCTGAAGATGATGTAGATAAAGAAGTA
CAAAAAGCGAAAAGTCAATACGGAGATCAATTCAAAAACATATTGAAAAACAATGGTTTAAAAGATGAAGCTGATTTTAA
AAATCAAATTAAGTTCAAACTTGCTATGAATGAAGCAATTAAAAAAAGTGTTACAGAAAAAGACGTGAAAGCCCACTACA
AACCAGAAATTAAAGCGAGCCACATTTTAGTAAGTGACGAAAATGAAGCGAAAGAAATAAAGAAAAAATTAGATGTAGGT
GCTTCATTTGAAGAACTAGCAAAACAAGAATCGCAAGACCTATTATCAAAAGAAAAAGGCGGAGACCTTGGGTACTTCAA
TTCAGGTAGAATGGCACCTGAATTTGAAACTGCTGCCTATAAACTAAAGGTCGGACAAATTAGCAATCCCGTTAAATCAC
CAAACGGTTATCATATTATTAAATTAACTGATAAAAAAGAGTTAAAACCCTATGATGAAGTGAAAGACTCTATTCGCAAA
AACTTAGAAGAAGAACGTATCGCTGATCCTACATTCAGTCACAAATTACTACAAAAGGAATTAAAAAAGGCAAATATTAA
AATAAACGATAGTGAGTTAGAAGATACCTTTACTATTGTTTCTTCGCAAGGAAATTAA

Upstream 100 bases:

>100_bases
TGTACTTTTTTACATTTTACAGGAAAAAACATTAAAAATTCACTTCATGTTCACTTCTATATTCTACAATAGCGATAACA
TATTCGGATGAGGTGTTAGC

Downstream 100 bases:

>100_bases
AAAAGCACAACCTTATTTTTTAGATAAGGTTGTGCTTTTTATTTCCTTTATTTCTTAAAGTACGTCCAACCTTCTTCTTG
GTAAACCTTTTCTTCTTTCA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRGKHIFIITALISILMLAACGQKDSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSEDDVDKEV
QKAKSQYGDQFKNILKNNGLKDEADFKNQIKFKLAMNEAIKKSVTEKDVKAHYKPEIKASHILVSDENEAKEIKKKLDVG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVKSPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERIADPTFSHKLLQKELKKANIKINDSELEDTFTIVSSQGN

Sequences:

>Translated_285_residues
MRGKHIFIITALISILMLAACGQKDSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSEDDVDKEV
QKAKSQYGDQFKNILKNNGLKDEADFKNQIKFKLAMNEAIKKSVTEKDVKAHYKPEIKASHILVSDENEAKEIKKKLDVG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVKSPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERIADPTFSHKLLQKELKKANIKINDSELEDTFTIVSSQGN
>Mature_285_residues
MRGKHIFIITALISILMLAACGQKDSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSEDDVDKEV
QKAKSQYGDQFKNILKNNGLKDEADFKNQIKFKLAMNEAIKKSVTEKDVKAHYKPEIKASHILVSDENEAKEIKKKLDVG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVKSPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERIADPTFSHKLLQKELKKANIKINDSELEDTFTIVSSQGN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=199, Percent_Identity=28.643216080402, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=39.2857142857143, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=60, Percent_Identity=55, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32225; Mature: 32225

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKHIFIITALISILMLAACGQKDSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMM
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSEDDVDKEVQKAKSQYGDQFKNILKNNGLKDEADFKNQIKFKLAMNEAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KKSVTEKDVKAHYKPEIKASHILVSDENEAKEIKKKLDVGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFNSGRMAPEFETAAYKLKVGQISNPVKSPNGYHIIKLTDKKELKPYDEVKDSIRK
CCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERIADPTFSHKLLQKELKKANIKINDSELEDTFTIVSSQGN
CHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHHHHHEEEECCCC
>Mature Secondary Structure
MRGKHIFIITALISILMLAACGQKDSSATVATATDSTITKSDFEKQLKDRYGKDMLYEMM
CCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSEDDVDKEVQKAKSQYGDQFKNILKNNGLKDEADFKNQIKFKLAMNEAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KKSVTEKDVKAHYKPEIKASHILVSDENEAKEIKKKLDVGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFNSGRMAPEFETAAYKLKVGQISNPVKSPNGYHIIKLTDKKELKPYDEVKDSIRK
CCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERIADPTFSHKLLQKELKKANIKINDSELEDTFTIVSSQGN
CHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539 [H]