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The map label for this gene is yisQ [H]

Identifier: 52144144

GI number: 52144144

Start: 1190784

End: 1192178

Strand: Reverse

Name: yisQ [H]

Synonym: BCZK1082

Alternate gene names: 52144144

Gene position: 1192178-1190784 (Counterclockwise)

Preceding gene: 52144142

Following gene: 52144150

Centisome position: 22.49

GC content: 40.65

Gene sequence:

>1395_bases
ATGACAGCAATTCAGGCAAAAAACAGGCCGGCAGAGAAATTAAGTTTATTCCTATTAACATGGCCTATTTTTCTAGAAGT
TTTTCTATTTATGTTAATGGGGATCGCTGATACTTTCATGTTAAGTGCATTATCAGACGATGCTGTATCTGGGGTTGGTG
CAGCGAATCAATATCTCCATATCGCTATTTTGGTACTAGAAGTCATCGGGAACGGCGCAGCTATCGTCGTATCTCAATAC
CTCGGTTCCAAACGTTTTATGGAAGCATCTAAAATATCAGCTTTAGCCGTCACATTAAATTTAGTAGTCGGACTCGTTAT
AAGCGCTGGTTTTCTTTTATTCTCAAAACATATGATGATGGCAATGAACTTACAAGGCGATGTACTTATGTATGCACAAA
GCTATTTATCTATCGTCGGGGGAGCTATTTTCCTTCAAGCTATTATTAATTCATTGGCCGCAATTATCCGCGTACATGGC
TTCACAAAGCAAGCGATGTTTATTTCACTTGGAATGAATATTATTCATATCGCTGGAAACTACGTACTCATTTTCGGGAA
ATTCGGTTTCCCAGAACTCGGTGTACAAGGGGCTGCCATTTCTTCTGCTGTCAGCAGGCTAATCGCGCTTATCGTTTTCT
TCTGGTTACTGTACCGCGTTATGGAGTACCGTGTGAAATTACAATACTACTTCACCTTATCAAAAGAATACATCGGGAAA
ATTTTAAAGATTGGGATTCCATCTGCATTTGAGCAGGTTATGTATCAAGCTTGCCAAATTGTCTTCTTATACTATGCAAC
ATATTTAGGGACGGAATCGTTAGCGGCTAGACAATACGCTACGAACATTTCTATGTTCACTTATTTATTCGCTATTGCAA
TCGGTATGGGAACTGCAATTATTATCGGACGCCTCGTTGGCGGTGGTGAAAAAGATGAAGCGTATGAACGCGTATGGAAA
AGTGTAAAGTGGGCGATTGGTGTCACTTTATGTATGGTTGCTCTCGTTATTACATTCCGCACACAATTAATGGGACTATT
TACAGATAATCCGCACATTATTGCGTTAGGTGCAAGCGTCCTTTTACTAAGTGTACTACTTGAAACAGGGCGTACGATGA
ACATCGTCATCATCAATTCACTTCGTGCAGCTGGTGATGCAAAGTACCCAGTTTTAATCGGCGCATTCTCTATGGTGTTA
ATGAGTTTACCACTCGGTTATTTTTTCGCCTTCCATTTAGATATGGGACTCGTTGGTATTTGGCTAGCAATTGCTATTGA
TGAATGGACGCGCGCCATTATTATGTTCTTCCGCTGGAAAAGTAGAGCGTGGGAGCGTTATGCACTTGTTAAACCTGAAG
AACAAGAGGAGATTGTTTCTGTTCAGGCGCAATAA

Upstream 100 bases:

>100_bases
TTCATAATAAAGATATGTAGGTTAAAATGAGTGCAAAGGTTAAGAAAGTATGTTACGATACACTTTGCTAAAAATAGATA
TCGGTAAAGAGGGGACGGAC

Downstream 100 bases:

>100_bases
TACGCGTTTCATTAAGGTGTAGTCATTCGTATAGGAAACTTATATTTGCGATTCTTTAAATATATCGACTTACCGAGAAA
TAGTGACAACTCTTTTAGAT

Product: efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTAIQAKNRPAEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQAQ

Sequences:

>Translated_464_residues
MTAIQAKNRPAEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQAQ
>Mature_463_residues
TAIQAKNRPAEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQYL
GSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGF
TKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGKI
LKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWKS
VKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLM
SLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQAQ

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=418, Percent_Identity=22.0095693779904, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI38261960, Length=450, Percent_Identity=21.3333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI226510954, Length=443, Percent_Identity=25.5079006772009, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=22.9398663697105, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51336; Mature: 51205

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIQAKNRPAEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMM
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHH
LLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHEECCC
>Mature Secondary Structure 
TAIQAKNRPAEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMM
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFWLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHH
LLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]