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The map label for this gene is dltA [H]

Identifier: 52143968

GI number: 52143968

Start: 1355996

End: 1357510

Strand: Reverse

Name: dltA [H]

Synonym: BCZK1261

Alternate gene names: 52143968

Gene position: 1357510-1355996 (Counterclockwise)

Preceding gene: 52143967

Following gene: 52143970

Centisome position: 25.61

GC content: 37.23

Gene sequence:

>1515_bases
ATGAAGTTATTAGAACAAATTGAAAAGTGGGCTATTGAAACGCCTGATCAAACTGCTTTTGTTTGGCGAGATGCGAAAAT
TACGTACAAACAATTAAAGGAAGATTCTGATGCGTTAGCACATTGGATTTCTTCTGAGTATCCAGATGATCGTTCACCAA
TTATGGTGTATGGCCATATGCAACCTGAAATGATTATTAACTTTTTAGGATGTGTAAAAGCTGGACACGCTTATATTCCT
GTAGATTTATCTATCCCAGCTGATCGTGTACAACGTATCGCTGAAAATTCTGGTGCGAAATTACTTTTATCAGCAGCAAC
AGTAACTGTAACTGATTTACCAGTTCGCATTGTAAGTGAAGACAACTTAAAAGATATTTTCTTTACTCATAAAGGGAACA
CTCCAAATCCTGAACATGCGGTAAAAGGTGATGAGAACTTCTACATTATTTACACATCAGGAAGCACAGGTAATCCGAAA
GGGGTTCAGATTACTTATAACTGCCTTGTAAGCTTTACACAATGGGCTGTAGAAGACTTCAACTTACAAACAGGGCAAGT
ATTCTTAAACCAAGCACCTTTCTCATTTGATTTATCTGTCATGGATATTTACCCATCATTAGTAACAGGTGGTACACTTT
GGGCAATCGATAAAGACATGATTGCACGTCCAAAAGACTTGTTTGCTTCTTTAGAGCAATCGGATATACAAGTATGGACT
TCCACACCATCTTTCGCAGAGATGTGTTTAATGGAAGCATCTTTCTCTGAGAGTATGCTACCAAACATGAAAACATTCTT
ATTCTGCGGTGAAGTATTACCAAATGAAGTAGCTAGAAAATTAATTGAGCGTTTCCCGAAAGCAACAATTATGAATACGT
ATGGTCCAACAGAAGCTACTGTCGCTGTAACAGGTATTCACGTTACAGAAGAAGTGCTTGATCAATACAAATCACTTCCA
GTTGGCTACTGTAAATCAGATTGTCGCCTTCTTATTATGAAAGAAGATGGCACAATTGCACCTGATGGTGAAAAAGGTGA
AATCGTAATTGTTGGTCCTAGCGTAAGCGTTGGATATTTAGGAAGCCCTGAATTAACAGAAAAAGCATTTACTATGATTG
ACGGTGAGCGCGCCTATAAAACAGGCGATGCTGGCTATGTTGAAAATGGTCTTCTATTCTATAATGGTCGTCTTGATTTC
CAAATTAAGCTGCATGGTTATCGAATGGAATTAGAAGAAATTGAGCATCATCTTCGTGCGTGTTCTTACGTAGAAGGAGC
AGTTATCGTTCCAATTAAAAAAGGTGAGAAATACGATTATTTATTAGCGGTTGTTGTTCCTGGAGAACATTCATTTGAAA
AAGAATTCAAATTAACATCTGCAATCAAAAAAGAACTCAATGAGCGATTACCAAACTACATGATTCCACGTAAATTCATG
TATCAATCTTCTATTCCAATGACACCAAATGGAAAGGTAGATCGCAAAAAATTATTGAGTGAGGTTACAGCATGA

Upstream 100 bases:

>100_bases
TTATTACCTTGCAATTTTATTTGCATTACTTTGGTTGTATGGATTCCATGATACAAACACAAGTACATTTATTTACAACG
AATTTTAGGGTGGGAACGTT

Downstream 100 bases:

>100_bases
CCGCATATGGATCATTTTATTTTTTCGCTATAGTGGGCATTTTATTAATACCTACTATCATAGCTGGATTAAAAGGTAAA
ATGTTGCGTAAATATAATGC

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Sequences:

>Translated_504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA
>Mature_504_residues
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAGHAYIP
VDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPK
GVQITYNCLVSFTQWAVEDFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLP
VGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDF
QIKLHGYRMELEEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
YQSSIPMTPNGKVDRKKLLSEVTA

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=361, Percent_Identity=26.5927977839335, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI187761345, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI187761343, Length=396, Percent_Identity=26.7676767676768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156151445, Length=545, Percent_Identity=22.5688073394495, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI157311624, Length=500, Percent_Identity=24.2, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI157311622, Length=500, Percent_Identity=24.2, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI58082049, Length=504, Percent_Identity=23.8095238095238, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=21.9512195121951, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786801, Length=533, Percent_Identity=30.0187617260788, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=23.5849056603774, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786810, Length=517, Percent_Identity=23.5976789168279, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI221142682, Length=466, Percent_Identity=22.5321888412017, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32563687, Length=497, Percent_Identity=24.3460764587525, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=486, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=26.890756302521, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=503, Percent_Identity=24.2544731610338, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=368, Percent_Identity=23.0978260869565, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=442, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=531, Percent_Identity=21.4689265536723, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=25.1366120218579, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560140, Length=506, Percent_Identity=22.5296442687747, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=434, Percent_Identity=24.6543778801843, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=570, Percent_Identity=24.9122807017544, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319699, Length=358, Percent_Identity=22.0670391061453, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648676, Length=521, Percent_Identity=25.9117082533589, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI18859661, Length=538, Percent_Identity=22.8624535315985, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355225, Length=532, Percent_Identity=21.8045112781955, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356441, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24581924, Length=368, Percent_Identity=22.554347826087, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56536; Mature: 56536

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEEEEEEECCEEEECC
DNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDF
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEEHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKLLEQIEKWAIETPDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHM
CCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECC
QPEMIINFLGCVKAGHAYIPVDLSIPADRVQRIAENSGAKLLLSAATVTVTDLPVRIVSE
CHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEEEEEEEECCEEEECC
DNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTQWAVEDF
CCCEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHC
NLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQSDIQVWT
CCCCCEEEEECCCCEECEEHHHHHHHHHCCCEEEEECHHHHCCCHHHHHHCCCCCEEEEE
STPSFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMNTYGPTEAT
CCCHHHHHHHHHHCCCHHHCCCHHHHHHCCHHCHHHHHHHHHHHCCCEEEEECCCCCCEE
VAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVGPSVSVGYL
EEEEEEEHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCEECCC
GSPELTEKAFTMIDGERAYKTGDAGYVENGLLFYNGRLDFQIKLHGYRMELEEIEHHLRA
CCCCHHHHHHHEECCCHHEECCCCCEEECCEEEECCEEEEEEEEECEEECHHHHHHHHHH
CSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLPNYMIPRKFM
HHHCCCEEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YQSSIPMTPNGKVDRKKLLSEVTA
HCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA