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The map label for this gene is norM [H]

Identifier: 52143961

GI number: 52143961

Start: 1363063

End: 1364424

Strand: Reverse

Name: norM [H]

Synonym: BCZK1269

Alternate gene names: 52143961

Gene position: 1364424-1363063 (Counterclockwise)

Preceding gene: 52143958

Following gene: 52143963

Centisome position: 25.74

GC content: 35.76

Gene sequence:

>1362_bases
ATGAAAGAAACTAATTCATTTTCACAAAAATTAAAGCAATTTGCATTACTATTTTTCCCGATTTTCGTTACGCAAATGTC
ATTATTTGCAATGAGTTTTTTCGATACGACCATGTCAGGACATGCAAGCCCTATTGATTTAGCAGGTGTTGCTATCGGAA
CAAGTATATGGATTCCAGTTAGTACGGGATTAACAGGAATTTTGATGGCTACGACTCCAATTGTTGCACAACTCGTTGGA
TCTAAGAAAAAAGAGGATGTTCCTCACGTTGTCATACAAGCAGTTTATTTAGCAATTTGTGCTAGCTTCGTCGTTATCCT
TATAGGTTTATTTACTGTTACACCTATTTTAAATGGCATGCGATTAGAAGAACCTGTAGAACGTATTGCGGCACAATTTT
TAAGTATTATCGCAATTGGAATTATCCCTTTATTTACTTACACAGTTTTACGCGGATTTATTGATGCATTAGGAAAAACT
CGCACAACGATGATCATTACATTACTATCATTACCTATTAACGTAATATTAAATTACTTATTAATTTTTGGTAACTTTGG
TTTTCCAAAACTCGGTGGTGTCGGAGCGGCAATTGCTTCCACTGCAACATATTGGTGCATTTTAATTATTACAGTCATTA
TCATTCATACGAAAGAGCCTTTCGCCTCTTTCAATATCTTTAAACATTTATATCGTCCTTCTCTTTCGAGTTGGAAAGCA
TTCTTAAAACTTGGCGTCCCTATCGGATTTGCTATCTTTTTTGAAACGAGTATTTTTGCTGCGGTAACACTTATGATGAG
TAATTTTAGTACGACAACAATCGCAGCTCATCAGGCAGCTATGAACTTCGCTTCCTTGCTATATATGACTCCTTTAAGTT
TAGCAATGGCAATGACCATCGCTGTTGGATTTGAAGTTGGAGCGAAACGATATAATAACGCAAAACAGTATGGATTTATC
GGGATTGGATTAGCACTGGCATTCGCCCTATTATATTCCATTCTTCTTTACTTCTTTGATAATGAAATTGCTTCTATTTA
TACGACAGATATACAAGTTCATCATTTAGCAAAAGAATTTCTTATATTTGCGATTTTATTTCAAATTTCAGATGCAATTG
CGACTCCTGTACAAGGGGCACTACGTGGTTATAAAGATGTAAATGTTGCCTTAATTATGACATTAATCGCCTATTGGGTA
ATAGGTCTCCCTCTTGGTTACATATTAGCAACTTATACTGACTGGGCAGCAAAAGGATATTGGATTGGTCTTATTATCGG
TCTAGCATTTGGAGCAACCTTCCTCCTTATCCGTCTCTTTCAAGTTCAGAGAAAATATACAACGCAAAACAACCGCTCAT
AA

Upstream 100 bases:

>100_bases
TTTATTGAATTTACATGTTGTATGCGCGTATTTCTTTTCTATTTTTTGATTAAATTGTATGATAGTAAGAGTTTGGTTTT
TTTAGCGGAAAGGGGATTTT

Downstream 100 bases:

>100_bases
TATAGCGGTTGTTTTCTTTATGCATATTTTTTCTTGTAACGTATAACATAATGAAAAAGAAAGGTGGATACATATGGACG
AAAAAGAAAAAAAGCAATCA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKETNSFSQKLKQFALLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIHTKEPFASFNIFKHLYRPSLSSWKA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDNEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNNRS

Sequences:

>Translated_453_residues
MKETNSFSQKLKQFALLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIHTKEPFASFNIFKHLYRPSLSSWKA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDNEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNNRS
>Mature_453_residues
MKETNSFSQKLKQFALLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIHTKEPFASFNIFKHLYRPSLSSWKA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDNEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNNRS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=448, Percent_Identity=22.5446428571429, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI153792564, Length=413, Percent_Identity=24.455205811138, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38261960, Length=438, Percent_Identity=22.8310502283105, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI48994890, Length=434, Percent_Identity=36.405529953917, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI226510954, Length=456, Percent_Identity=22.8070175438596, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=410, Percent_Identity=23.6585365853659, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321821, Length=394, Percent_Identity=22.3350253807107, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49767; Mature: 49767

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKETNSFSQKLKQFALLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEE
STGLTGILMATTPIVAQLVGSKKKEDVPHVVIQAVYLAICASFVVILIGLFTVTPILNGM
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKTRTTMIITLLSLPINVILNYL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIHTKEPFASFNIFKHLYRPSLSSWKA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHH
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTI
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFDNEIASIYTTDIQVHHLAKEF
HHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHHH
LIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWVIGLPLGYILATYTDWAAKGY
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
WIGLIIGLAFGATFLLIRLFQVQRKYTTQNNRS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA