Click here to switch to the map view.

The map label for this gene is serA [C]

Identifier: 52143931

GI number: 52143931

Start: 1391074

End: 1392045

Strand: Direct

Name: serA [C]

Synonym: BCZK1299

Alternate gene names: 52143931

Gene position: 1391074-1392045 (Clockwise)

Preceding gene: 52143930

Following gene: 52143927

Centisome position: 26.24

GC content: 36.52

Gene sequence:

>972_bases
GTGGCAAAAATATTAGTAGCAGGAAAAATTCCAGAAATCGGATTAGAACTATTAAAAGATCATGATGTGGAAATGTATGA
TAAAGAGGAGTTAATTTCTTTAGATGAATTAACAGAGCGTGTAAAAGATAAAGATGCATTGCTAAGTCTACTTTCTACAA
AGGTGACAAAAGAAGTGATTGATGCGGCATCTAATTTGAAGATTGTTGCAAACTACGGTGCTGGTTATGATAATATTGAT
TACACGTATGCTGGAGAAAAAGGGATTGCGGTAACGAATACACCGAAAGTATCAACGGAAGCGACAGCAGAATTAACATT
TGCACTTCTTTTAGCAGCTGCACGTAGAATTCCTGAAGGTGATACGCTATGCCGTACAACGGGATTTAACGGATGGGCAC
CGTTATTTTTCTTAGGTCGAGAAGTACATGGTAAAACAATTGGAATTATTGGCCTTGGAGAAATCGGAAAGGCAGTTGCA
AAACGTGCGAAAGCATTTGGAATGAATATTTTATATACAGGACCAAATCGAAAACCTGAAGCTGAAAGTGAACTGGAAGC
AACATATGTAACATTGGAAGAGTTATTACAAACAGCAGACTTTATTACAATTAACTGTGCGTATAATCCGAAATTGCATC
ATATGATTGATGAAGAGCAGTTTAAAATGATGAAGAAAACAGCGTATATTGTAAATGCTTCACGTGGACCAATTATGCAC
GAAGCGGCACTTGCTCATGCGTTAAAAACGAATGAAATTGAAGGAGCAGCTCTTGATGTGTTTGAATTTGAACCGAAAAT
TACTGAAGAGTTAAAAGGATTAAAGAATGTAGTACTTGCTCCTCACGTAGGAAATGCAACATTTGAAACGCGTGATGCGA
TGGCTGAAATGGCAGTAAGAAATATTTTAGCTGTATTAAATGGTGAAGAACCTGTAACACCTGTAAATCAAAAAGTATTC
GTTACAAAATAA

Upstream 100 bases:

>100_bases
ATTTTCAAAACTATAATCAAATTCCTTGGTTTTTATATGTGGATTTCTTACAATGAAAGATAAGAGATATCCTATTTTGT
ATAGAAGAGGTGTTAGTATA

Downstream 100 bases:

>100_bases
AAAGAAACCTTCCGGAACCGGAAGGTTTCTTTTTATTTTTCTTTATTTGCTCTTTTTGATGGTCTTTGTCTAAGGAATTG
AGATAGCATGTACAAAATAT

Product: glycerate dehydrogenase

Products: 3-phosphohydroxypyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAKILVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKVTKEVIDAASNLKIVANYGAGYDNID
YTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVA
KRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMH
EAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAEMAVRNILAVLNGEEPVTPVNQKVF
VTK

Sequences:

>Translated_323_residues
MAKILVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKVTKEVIDAASNLKIVANYGAGYDNID
YTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVA
KRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMH
EAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAEMAVRNILAVLNGEEPVTPVNQKVF
VTK
>Mature_322_residues
AKILVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKVTKEVIDAASNLKIVANYGAGYDNIDY
TYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAK
RAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMHE
AALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAEMAVRNILAVLNGEEPVTPVNQKVFV
TK

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=315, Percent_Identity=39.0476190476191, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI23308577, Length=322, Percent_Identity=33.2298136645963, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI61743967, Length=320, Percent_Identity=35.3125, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI4557497, Length=320, Percent_Identity=35.3125, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=334, Percent_Identity=33.2335329341317, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4557499, Length=334, Percent_Identity=33.2335329341317, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI145580575, Length=333, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI87082289, Length=267, Percent_Identity=38.2022471910112, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789279, Length=265, Percent_Identity=32.0754716981132, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=30.8880308880309, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788660, Length=257, Percent_Identity=29.1828793774319, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=33.4384858044164, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=318, Percent_Identity=30.8176100628931, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=313, Percent_Identity=31.629392971246, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=37.344398340249, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=316, Percent_Identity=31.9620253164557, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321253, Length=293, Percent_Identity=25.5972696245734, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=322, Percent_Identity=27.0186335403727, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=306, Percent_Identity=39.8692810457516, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=35.2201257861635, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=34.0694006309148, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=34.0694006309148, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=34.0694006309148, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=34.0694006309148, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=34.0694006309148, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921140, Length=315, Percent_Identity=34.6031746031746, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646446, Length=332, Percent_Identity=33.7349397590361, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646448, Length=332, Percent_Identity=33.7349397590361, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646452, Length=332, Percent_Identity=33.7349397590361, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24646450, Length=332, Percent_Identity=33.7349397590361, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI62472511, Length=319, Percent_Identity=34.1692789968652, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=29.3375394321767, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.95

Molecular weight: Translated: 35392; Mature: 35261

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKVTKEVI
CCEEEEECCCCHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEG
HHCCCEEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
DTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPE
CCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCCC
AESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMH
CHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHCCHHHHHHHHHHHEEEECCCCCCHH
EAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAEMAVR
HHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
NILAVLNGEEPVTPVNQKVFVTK
HHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
AKILVAGKIPEIGLELLKDHDVEMYDKEELISLDELTERVKDKDALLSLLSTKVTKEVI
CEEEEECCCCHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEG
HHCCCEEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCC
DTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPE
CCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCEEEEECCCCCCC
AESELEATYVTLEELLQTADFITINCAYNPKLHHMIDEEQFKMMKKTAYIVNASRGPIMH
CHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHCCHHHHHHHHHHHEEEECCCCCCHH
EAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMAEMAVR
HHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
NILAVLNGEEPVTPVNQKVFVTK
HHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-phosphoglycerate; NAD+

Specific reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA