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The map label for this gene is cysG [H]

Identifier: 52143921

GI number: 52143921

Start: 1402211

End: 1402987

Strand: Direct

Name: cysG [H]

Synonym: BCZK1309

Alternate gene names: 52143921

Gene position: 1402211-1402987 (Clockwise)

Preceding gene: 52143920

Following gene: 52143918

Centisome position: 26.45

GC content: 40.15

Gene sequence:

>777_bases
ATGGGAAAAGTATATATCGTTGGGGCGGGCCCTGGGGATCCAGATTTAATTACTGTGAAAGGATTGAAATGTATTGAGAA
GGCAGATGTTATTTTGTACGACCGTCTCGTAAATAAAGAATTGCTTTCCTATGCAAAGCCTGAAGCGGATTTAATTTATT
GCGGAAAACTACCAAATTATCACACGATGAAGCAAGAGACAATTAACACGTTTCTTATTAAATATGCGAAAAAAGGAAAA
ATTGTAACGAGACTTAAGGGTGGGGATCCATTTGTATTTGGTAGAGGAGGAGAAGAGGCCGAAGCGTTAGCAAAGCAAGG
TGTAGCATTTGAAATTGTTCCTGGTATTTCAGCTGGAATAGCTGCACCTGCTTATGCGGGTATTCCAGTGACACATCGTG
ATGCAAGTGCAAGCTTTGCTATTGTGACAGGGCATCGAAAAGAAGATGTTGCAGAGGAAGTGAAATGGGAAAATTTAGCG
AAAGGTGTAGAGACTTTAGCGGTATATATGGGGGTTAGCAATTTACCCTACATATGTGAACAACTGATGAAGCATGGAAA
AGATAAAAGTACGCCTGCTGCTATTATTGAGCGGGGAACGACATCTATGCAACGCACAGTTGTTGGGACGTTAGGAACAA
TTGTAGATGTTGCGAGAAAAGAACAAATTCAAAATCCAAGCATGATTGTAATTGGAGAAGTCGTCCGTTTTAGAGAAAAA
ATCCATTGGTTTGAAAAGCAGACAGAAAGCACGTATCAAGTAAGTGGAGTGTTATAA

Upstream 100 bases:

>100_bases
TTATTCATGAGTAAGGAACATTGAAATATGAAGAAATGAAAACTTCCATTCATATATAAGGATGGAAGTTTCACTTTAAT
AGTAGAAATGAGGAGAGATG

Downstream 100 bases:

>100_bases
AATGAAAGCCATCTTATATATATGTCATGGAAGTCGCTTGAAAGCAGCTAAAGAAGAAGCGGTTGCATTTATTACGTCAT
GTATGAACCGTGTAGAGGCA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
IVTRLKGGDPFVFGRGGEEAEALAKQGVAFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDVAEEVKWENLA
KGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVARKEQIQNPSMIVIGEVVRFREK
IHWFEKQTESTYQVSGVL

Sequences:

>Translated_258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
IVTRLKGGDPFVFGRGGEEAEALAKQGVAFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDVAEEVKWENLA
KGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVARKEQIQNPSMIVIGEVVRFREK
IHWFEKQTESTYQVSGVL
>Mature_257_residues
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNYHTMKQETINTFLIKYAKKGKI
VTRLKGGDPFVFGRGGEEAEALAKQGVAFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDVAEEVKWENLAK
GVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVARKEQIQNPSMIVIGEVVRFREKI
HWFEKQTESTYQVSGVL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=47.1544715447154, Blast_Score=245, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=32.0675105485232, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28184; Mature: 28053

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNY
CCEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKIVTRLKGGDPFVFGRGGEEAEALAKQGVAFEIVPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCEEEECCCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEDVAEEVKWENLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVARKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTESTYQVSGVL
HHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEADLIYCGKLPNY
CEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKIVTRLKGGDPFVFGRGGEEAEALAKQGVAFEIVPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCEEEECCCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEDVAEEVKWENLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVARKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTESTYQVSGVL
HHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]