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The map label for this gene is map [H]

Identifier: 52143784

GI number: 52143784

Start: 1531619

End: 1532365

Strand: Direct

Name: map [H]

Synonym: BCZK1447

Alternate gene names: 52143784

Gene position: 1531619-1532365 (Clockwise)

Preceding gene: 52143785

Following gene: 52143783

Centisome position: 28.89

GC content: 36.81

Gene sequence:

>747_bases
ATGATTACAATTAAAACGAAAAATGAAATAGATTTAATGCATGAATCTGGAAAGTTACTTGCTTCATGTCATAGAGAAAT
TGCGAAGATAATGAAACCAGGTATTACAACAAAAGAAATTAATACGTTTGTGGAAGCGTATTTAGAAAAACATGGTGCAA
CGTCTGAGCAGAAAGGGTACAACGGATATCCATATGCGATATGTGCATCTGTAAACGATGAAATGTGTCATGCATTTCCG
GCCGATGTTTCTTTAAACGAGGGGGATATTGTAACAATTGACATGGTAGTAAACTTAAATGGTGGTCTTTCAGATTCTGC
TTGGACGTATAGAATTGGAAAAGTTTCTGATGAAGCAGAAAAGTTATTACTAGTAGCTGAAAATGCTTTGTATAAAGGAA
TTGATCAGGCGGTGATCGGTAATCGTGTAGGAGATATTGGCTATGCAATTGAGAGTTATGTAGCAAATGAAGGTTTTTCT
GTCGTGAGAGACTTCACTGGACATGGGATTGGTAAAGAGATTCATGAAGAACCAGTAATTTTTCATTTTGGGAAGCAAGG
TCAAGGGCCAGAGCTACAAGAAGGCATGGTAATTACGATTGAGCCAATTGTCAATGTAGGTATGCGATATTCGAAAGTAG
ATTTAAATGGATGGACCGCGAGAACGATGGACGGGAAATTATCAGCTCAATATGAACATACAATTGCGATTACAAAAGAT
GGACCAATCATTTTAACGAAGTTATAA

Upstream 100 bases:

>100_bases
AAATACTAGATGTAATATTAATTGAAAGTGTTGAAAGAGTATGTGTATCATTGAAATTTAGTAGCAAATAGTAGGTCTAG
CAAGGAAGGTAGAGATAAGC

Downstream 100 bases:

>100_bases
TTGGGAATGAAAGAGTTTACAAAAATCGAACGAAAATGATAATTTCATAAAATTTGTACGTGTTTTATGAATAAAAGCTT
TTCAAAGTATAAAAAGTGCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP
ADVSLNEGDIVTIDMVVNLNGGLSDSAWTYRIGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS
VVRDFTGHGIGKEIHEEPVIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD
GPIILTKL

Sequences:

>Translated_248_residues
MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP
ADVSLNEGDIVTIDMVVNLNGGLSDSAWTYRIGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS
VVRDFTGHGIGKEIHEEPVIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD
GPIILTKL
>Mature_248_residues
MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP
ADVSLNEGDIVTIDMVVNLNGGLSDSAWTYRIGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS
VVRDFTGHGIGKEIHEEPVIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD
GPIILTKL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=36.0323886639676, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=35.7142857142857, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=40.3225806451613, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=35.3413654618474, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323273, Length=227, Percent_Identity=36.5638766519824, Blast_Score=142, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=37.7049180327869, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=38.0566801619433, Blast_Score=160, Evalue=8e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27194; Mature: 27194

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGY
CEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASVNDEMCHAFPADVSLNEGDIVTIDMVVNLNGGLSDSAWTYRIGKVSDEAE
CCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCHH
KLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVVRDFTGHGIGKEIHEEPVI
EEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHCCCCEE
FHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD
EEECCCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEEEEECC
GPIILTKL
CCEEEEEC
>Mature Secondary Structure
MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGY
CEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGYPYAICASVNDEMCHAFPADVSLNEGDIVTIDMVVNLNGGLSDSAWTYRIGKVSDEAE
CCCCEEEEECCCCHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCCCCHH
KLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVVRDFTGHGIGKEIHEEPVI
EEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHCCCCEE
FHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD
EEECCCCCCCCCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEEEEEECC
GPIILTKL
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]