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The map label for this gene is mepA [H]

Identifier: 52143747

GI number: 52143747

Start: 1580514

End: 1581869

Strand: Direct

Name: mepA [H]

Synonym: BCZK1486

Alternate gene names: 52143747

Gene position: 1580514-1581869 (Clockwise)

Preceding gene: 52143748

Following gene: 52143746

Centisome position: 29.82

GC content: 35.03

Gene sequence:

>1356_bases
ATGGAAGTAACAGAAAAATTAAGAGAAAAACCAATCAAAAGTTTATTTATCACTTATTTAATACCAGCCGTTCTCGGAAT
GGTATTAATGTCAGTTAATATTGTGATTGACGCGGTTATGATTAGTAGGGGAGTTGGAGCGAACGGATTAGCAGGAGTAA
ACGTGGCTATTCCAGCGTTTTCAATTTTCTTCTCTATTTCATTATGGATTGGAATGGGCGGGGCAACGTTATATTCCATT
GCGTTAGGTGAAAATAAAATAGAAAGAGCAAGGTCTATTTTTACTCAATCCATGACAGTGGCAGTCATTATCGTAGGTAT
TTTAGCAGCGATTTGCTTATGGAGAATAGAAGATTTAGCGTATTTATTCGGTGCAAATGAAGTGATTTTACCGTATGCGT
TAGATTATTTACACGTGTTATTAACATTTGGAATGATATACGTTTTAGAAAATATTTTAAGTACATTTATACGAAATGAT
GGAAATCCTAATTTAGCAATGGCAGGTCTTGTTGTAACAGCTGTATTAAACATAGTGTTTGACTATATCTTTATTTTTAT
TTTTGGATGGGGCGTAACAGGAGCTGCTTCAGCAACTATTCTTTCGGCAGCAATTGGTTTCCTTGTATTATTAACGCATT
TCTTTAGAAAAAGTAGTATTTTAAAGTGGACGAAATTCCATTTTGAATGGGATACGATTAAACAAATTATGATAATCGGT
TTTCCGAGCTTTATAACAGAAAGTACAGTGGCAATCGTAACGATTGGTTTTAATATAGCATTCGTTCAATATGCAGGAGA
AGTAGGCGTAGCTTCCTATGCGATGGTAAACAGCATTCATGCGATGACATTACTATTATTCTTCGGTGTAGGTGCTGCAT
TGCAACCAATTGCTAGTTTCCATTACGGTGCAAATTTATCAGAAAGATTACGTGAAGGATTACAGTTTGCTGTGAAAATT
GCAGTTATACTTGGCGGCGTTGCGATAATTGTCGGATTATTCTTCGGGAAATATATTATTGGCCTATTTGATGTCCAATC
TCCACAATTATTGGAGTTAACATTAACAGGTATTAGTTTGTTCTTTATCCAATACGTATTTTTAGGCTATAACATTGTGT
ATGGAGAGTACTTCCAATCAGTACGACAAACGAAGAAATCAGTACTGATTATAATGAGCCGAGGGCTACTATTCATTATT
CCATTATTATGGATTATGCCAAAGTTATTTGGGATAAACGGAATTTGGCTCGTTATGCCAGTAGCTGAAGTAATAACAGC
GATTATCTTATTTACGATGAATCGTATGAAACATCCTGTTCCATTAAACATGGCAGGAGAGAAGGAAGTAATATAA

Upstream 100 bases:

>100_bases
TAATATAATTCAGTTACCTATTTTTTAATTCTCTCTTGACCTTCAAGTTACTTTAAGGTTTAAACTGTGAACAGAGCGTT
GAAAAAAGGAGCAAAATAGT

Downstream 100 bases:

>100_bases
TGAAGAAAATCCCCTTGAGCAAGTAAGGGGATTTTTTATTTTTTTAAACTAATAGCAAAAGATCCATCAATTTCTTGAAC
AGAAGCAAAGGCAACATTTT

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVILGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVITAIILFTMNRMKHPVPLNMAGEKEVI

Sequences:

>Translated_451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVILGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVITAIILFTMNRMKHPVPLNMAGEKEVI
>Mature_451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVILGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVITAIILFTMNRMKHPVPLNMAGEKEVI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49666; Mature: 49666

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTIKQIMIIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHHHHHHHHC
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLQFAVKIAVILGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVITAIILFTMNRMKHPVPLNMAGEKEVI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTIKQIMIIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHHHHHHHHC
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLQFAVKIAVILGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVITAIILFTMNRMKHPVPLNMAGEKEVI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA