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The map label for this gene is acr3 [H]

Identifier: 52143507

GI number: 52143507

Start: 1850132

End: 1851097

Strand: Reverse

Name: acr3 [H]

Synonym: BCZK1727

Alternate gene names: 52143507

Gene position: 1851097-1850132 (Counterclockwise)

Preceding gene: 52143500

Following gene: 52143520

Centisome position: 34.92

GC content: 33.75

Gene sequence:

>966_bases
ATGAGCACGATAGAAAAGATTCAAACTTTTATTATTCTTTTTGCTGTTATCTGCGGCATCATACTTGGACAATTTAATGT
TATACATATGTATTCAGACAAATTTATTGTTCCCTTCTTATTTTTCATGCTATATGGATTATTCCTCAGCATCCCATTGA
AAGAAATAAAAAACGGATTTCGCAATTTAAAATTTGCTGGAACAAGCCTTACTATTAACTTTTTATGGACACCTTTACTC
GCTTGTGGATTAGGAGCACTATTTCTTTCAGATCACCCTGCGCTTTGGGTTGGATTTATAATGCTAATGGTTACTCCATG
TACAGATTGGTACTTAATCTTTACTGAAATAGCAAAAGGTAATGTAGCACTTTCTACAGCGATTTTACCAGTAAATTTAA
TTTTGCAAGTACTACTACTTCCCATTTATTTATTTTTATTCGCCGGTGTTATGAAGACTGTTACGGTTTCTGTTTTAGTA
GAAAGTATTGTTATCGTAATCGTCTTACCATTTTTACTTGCACACGCTACAAAATTCATTATGAATAAACTGAAAAAAGC
TGAAACGCTCGAGAATAAACTCATTCCGTTTTTCAGCTCTGCCCAAATTGTATTTTTAAGTTTAGCAATCGTAGCGATGT
TTGCATCACAAGGGAAATATTTACTACAAAATATGAATGTCGTTTTATTATTACTCATTCCTGTTCTATTGTTCTTCATC
ATTAATTTTGTACTAGGACAATTTATCGGGCGCGTTATGCGTTTATCTTATAAAGATACAGTAAGTCTAAATTTAACAAC
ATTAGCAAGAAACTCGCCTGTAGCACTCGCTATTGCTGTGACTGCTTTCCCAGACGAACCTCTTATCGCACTTGCACTTG
TTATTGGGCCGTTAATTGAGTTACCAATTCTCGCTTGTGTTTCACAAGTGTTGTTACTTATTAAGAAGAAGCAGCAATAT
ACATAA

Upstream 100 bases:

>100_bases
TAAAAACATTAACTAAAATACAATTGAACACCAAATTACAACCTTATTACTTGTATAATAAACTTAGAGAGGAAAATTCA
TATTTAGAAAGGATTCATTC

Downstream 100 bases:

>100_bases
TAAAAAACGTCCTGCTATAGGACGTTTTTTATTGTCGAGAAATTATATAATGAACGATCATTATCGGCTCTAAGCATTTT
ATACGTTATAGAAGAATTAA

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSTIEKIQTFIILFAVICGIILGQFNVIHMYSDKFIVPFLFFMLYGLFLSIPLKEIKNGFRNLKFAGTSLTINFLWTPLL
ACGLGALFLSDHPALWVGFIMLMVTPCTDWYLIFTEIAKGNVALSTAILPVNLILQVLLLPIYLFLFAGVMKTVTVSVLV
ESIVIVIVLPFLLAHATKFIMNKLKKAETLENKLIPFFSSAQIVFLSLAIVAMFASQGKYLLQNMNVVLLLLIPVLLFFI
INFVLGQFIGRVMRLSYKDTVSLNLTTLARNSPVALAIAVTAFPDEPLIALALVIGPLIELPILACVSQVLLLIKKKQQY
T

Sequences:

>Translated_321_residues
MSTIEKIQTFIILFAVICGIILGQFNVIHMYSDKFIVPFLFFMLYGLFLSIPLKEIKNGFRNLKFAGTSLTINFLWTPLL
ACGLGALFLSDHPALWVGFIMLMVTPCTDWYLIFTEIAKGNVALSTAILPVNLILQVLLLPIYLFLFAGVMKTVTVSVLV
ESIVIVIVLPFLLAHATKFIMNKLKKAETLENKLIPFFSSAQIVFLSLAIVAMFASQGKYLLQNMNVVLLLLIPVLLFFI
INFVLGQFIGRVMRLSYKDTVSLNLTTLARNSPVALAIAVTAFPDEPLIALALVIGPLIELPILACVSQVLLLIKKKQQY
T
>Mature_320_residues
STIEKIQTFIILFAVICGIILGQFNVIHMYSDKFIVPFLFFMLYGLFLSIPLKEIKNGFRNLKFAGTSLTINFLWTPLLA
CGLGALFLSDHPALWVGFIMLMVTPCTDWYLIFTEIAKGNVALSTAILPVNLILQVLLLPIYLFLFAGVMKTVTVSVLVE
SIVIVIVLPFLLAHATKFIMNKLKKAETLENKLIPFFSSAQIVFLSLAIVAMFASQGKYLLQNMNVVLLLLIPVLLFFII
NFVLGQFIGRVMRLSYKDTVSLNLTTLARNSPVALAIAVTAFPDEPLIALALVIGPLIELPILACVSQVLLLIKKKQQYT

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 35692; Mature: 35561

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIEKIQTFIILFAVICGIILGQFNVIHMYSDKFIVPFLFFMLYGLFLSIPLKEIKNGF
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHH
RNLKFAGTSLTINFLWTPLLACGLGALFLSDHPALWVGFIMLMVTPCTDWYLIFTEIAKG
HCCEECCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
NVALSTAILPVNLILQVLLLPIYLFLFAGVMKTVTVSVLVESIVIVIVLPFLLAHATKFI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNKLKKAETLENKLIPFFSSAQIVFLSLAIVAMFASQGKYLLQNMNVVLLLLIPVLLFFI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHH
INFVLGQFIGRVMRLSYKDTVSLNLTTLARNSPVALAIAVTAFPDEPLIALALVIGPLIE
HHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
LPILACVSQVLLLIKKKQQYT
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STIEKIQTFIILFAVICGIILGQFNVIHMYSDKFIVPFLFFMLYGLFLSIPLKEIKNGF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHH
RNLKFAGTSLTINFLWTPLLACGLGALFLSDHPALWVGFIMLMVTPCTDWYLIFTEIAKG
HCCEECCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
NVALSTAILPVNLILQVLLLPIYLFLFAGVMKTVTVSVLVESIVIVIVLPFLLAHATKFI
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNKLKKAETLENKLIPFFSSAQIVFLSLAIVAMFASQGKYLLQNMNVVLLLLIPVLLFFI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHH
INFVLGQFIGRVMRLSYKDTVSLNLTTLARNSPVALAIAVTAFPDEPLIALALVIGPLIE
HHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
LPILACVSQVLLLIKKKQQYT
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]