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The map label for this gene is lcfB [H]

Identifier: 52143437

GI number: 52143437

Start: 1924894

End: 1926132

Strand: Direct

Name: lcfB [H]

Synonym: BCZK1797

Alternate gene names: 52143437

Gene position: 1924894-1926132 (Clockwise)

Preceding gene: 52143438

Following gene: 52143432

Centisome position: 36.31

GC content: 35.03

Gene sequence:

>1239_bases
ATGCTAATTGTTAATAGAGAAGAGTATAGCAAAAGTGATTTTGATTTGAGATTACAAGCTTATGGGGAAATGGAACAATT
TCAAGAAGCAGCAGGAAATAGATTTGCGCTTTGTCTGAAAGATCCATTCGATATTATTACGCTTGTGTTTTTCTTAAAAG
AAAAGAAATCATCCGTGTTACTTATACATGAAGATACGCCAAAAGAAACGGCTATTGAAATGGCGAAGCGTGCAAATTGT
ATCGGAATTTTATATGAAGAAAATAGCGATTTTACGAAATTAGAAGCAGTGAATTATTTAGCAGAAGAGCCTTCTTTATT
GCAATATAGTTCTGGAACTACAGGAGAACCGAAACTGATTCGTAGAGTATGGACGGAAGTTGATATAGAAATTAAGGCTT
ATAATGAAGCTTTAAACTGTGAAATAGATGAAGTACCGATTGTTATGGCTCCTGTTTCACATTCATACGGACTAATATGT
GGTACGTTATCTGCAATTACGAGGGGAAGCAGACCTATCATCATTACGAATAAAAATCCTAAATTCGCATTAAATATAGT
TCGCAATACAGAAAAACATATCATATATGCAGTACCACTTATGCTACATATCATGGGGAGTTTTCCGCAAGGAACGTTTC
AGTTTCATAAAATTATGACATCCGGAGCACCTTTGACAGAAGCATTATTTTATAAACTAAAAGAAAAGACAACATATATG
ATGCAACAATACGGTTGTTCTGAAGCAGGTTGTATTAGTATATGTCATGATATGAAAAACCATTTAGATTTAGGAAACCC
GCTACCTCATGCGAGTATAAGTATAGGTTCAGATGAAAATGCACCGGAAGAAATCGTAGTGAAAATGAATGATAAGGAAA
TTTTCACGAAAGATTTAGGGTATAAATCTGAACGTGGCCTTCATTTTATGGGGCGTATGGACGATGTGATTAACGTTTCA
GGATTAAAAGTGTTTCCTATAGAGGTAGAAGAAACGATGCTTCGATTGGAAGGTGTGCAAGAGGCGATTGTATATCGAGG
AAAACATCCTGTCATGGGGGAAATTGTTAAAGCGAAAGTAATCTCTCATATTGATTCAGTTCAAATAAGAGAATGGTGTA
TGCAGCATTTACCATCTTATAAAGTTCCGCATGAGATTGAAAGTGTAACTGAAATTCCGAAAAATAAAACTGGAAAAGTA
AGTAGAAAGTTACTAGAGATGGGAGAGGTTACAATATGA

Upstream 100 bases:

>100_bases
TTGTATATGGATGTGGAATCGCTAGTTCATGAAGTTCCAAATCCATTGTATAGAGCAAGACAACTTAACATACAAAAATT
AGTTGCTACAGGGGGAAATT

Downstream 100 bases:

>100_bases
GACGGGAAGCGTTAAAGAATGCTGTATTAAAAATTATGACAGAAAAAATGGAACTGAAAAATGTAACGCATTTAGAAGAA
ACGATGCGTTTAAATCAAGA

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MLIVNREEYSKSDFDLRLQAYGEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANC
IGILYEENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLIRRVWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSYGLIC
GTLSAITRGSRPIIITNKNPKFALNIVRNTEKHIIYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLTEALFYKLKEKTTYM
MQQYGCSEAGCISICHDMKNHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVS
GLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDSVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKV
SRKLLEMGEVTI

Sequences:

>Translated_412_residues
MLIVNREEYSKSDFDLRLQAYGEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANC
IGILYEENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLIRRVWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSYGLIC
GTLSAITRGSRPIIITNKNPKFALNIVRNTEKHIIYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLTEALFYKLKEKTTYM
MQQYGCSEAGCISICHDMKNHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVS
GLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDSVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKV
SRKLLEMGEVTI
>Mature_412_residues
MLIVNREEYSKSDFDLRLQAYGEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVLLIHEDTPKETAIEMAKRANC
IGILYEENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLIRRVWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSYGLIC
GTLSAITRGSRPIIITNKNPKFALNIVRNTEKHIIYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLTEALFYKLKEKTTYM
MQQYGCSEAGCISICHDMKNHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFTKDLGYKSERGLHFMGRMDDVINVS
GLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKVISHIDSVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKV
SRKLLEMGEVTI

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157311624, Length=368, Percent_Identity=24.4565217391304, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI157311622, Length=368, Percent_Identity=24.4565217391304, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI58082049, Length=368, Percent_Identity=23.9130434782609, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI115511026, Length=126, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI38505220, Length=362, Percent_Identity=24.3093922651934, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI42544132, Length=354, Percent_Identity=22.0338983050847, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI28416953, Length=168, Percent_Identity=30.3571428571429, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788107, Length=347, Percent_Identity=25.6484149855908, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI221142682, Length=347, Percent_Identity=21.9020172910663, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141359, Length=321, Percent_Identity=28.6604361370716, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=354, Percent_Identity=25.4237288135593, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=366, Percent_Identity=24.0437158469945, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994690, Length=359, Percent_Identity=22.5626740947075, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6319699, Length=428, Percent_Identity=22.196261682243, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 46625; Mature: 46625

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVNREEYSKSDFDLRLQAYGEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVL
CEEECCHHCCCCCCEEEEEECCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEE
LIHEDTPKETAIEMAKRANCIGILYEENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLI
EEECCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
RRVWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSYGLICGTLSAITRGSRPIIITNKNP
HHHHHHCEEEEEEECCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCC
KFALNIVRNTEKHIIYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLTEALFYKLKEKTTYM
CEEEEEEECCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MQQYGCSEAGCISICHDMKNHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFTKDLG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHCC
YKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKV
CCCCCCEEECCCCCCCEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ISHIDSVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLIVNREEYSKSDFDLRLQAYGEMEQFQEAAGNRFALCLKDPFDIITLVFFLKEKKSSVL
CEEECCHHCCCCCCEEEEEECCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEE
LIHEDTPKETAIEMAKRANCIGILYEENSDFTKLEAVNYLAEEPSLLQYSSGTTGEPKLI
EEECCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
RRVWTEVDIEIKAYNEALNCEIDEVPIVMAPVSHSYGLICGTLSAITRGSRPIIITNKNP
HHHHHHCEEEEEEECCCCCCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCC
KFALNIVRNTEKHIIYAVPLMLHIMGSFPQGTFQFHKIMTSGAPLTEALFYKLKEKTTYM
CEEEEEEECCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MQQYGCSEAGCISICHDMKNHLDLGNPLPHASISIGSDENAPEEIVVKMNDKEIFTKDLG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHCC
YKSERGLHFMGRMDDVINVSGLKVFPIEVEETMLRLEGVQEAIVYRGKHPVMGEIVKAKV
CCCCCCEEECCCCCCCEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ISHIDSVQIREWCMQHLPSYKVPHEIESVTEIPKNKTGKVSRKLLEMGEVTI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]