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The map label for this gene is moeA [H]

Identifier: 52143298

GI number: 52143298

Start: 2052670

End: 2053959

Strand: Direct

Name: moeA [H]

Synonym: BCZK1939

Alternate gene names: 52143298

Gene position: 2052670-2053959 (Clockwise)

Preceding gene: 52143299

Following gene: 52143296

Centisome position: 38.72

GC content: 38.91

Gene sequence:

>1290_bases
ATGTTAGAAAAACGTATACCAATTCCAGTGGCAGAAGCAGTTGCGCGTGTAATGGAATATGCTTACCAAGGTGAAATAGA
AAAGGTTTCTCTTATAGAAAGCTACGGTAGAACACTTGGAAAAGATGTTATTGCAGATCATGATGTCCCGCATTTCAATC
GCTCTCCATACGACGGATTTGCGATTCGAGCAGAAGATACAAAAGAAGCCAGTAGCAGTAATCCCATTCAGTTTGAAGTG
ATTGGTGAAATTGGAGCAGGTTTTGTCTTTACAGAAGAAGTGAAAGCATTTCAAGCTGTCCGTATTATGACAGGAGCCGC
AATTCCGAGAGGGTGTAATGCGGTTATTATGTTAGAACTAACGGAAGAATTTGAAAAAAACGAAAAGACTTATATGAAAT
TAAAACGCTCCTTCGCCTCCGGTGATAACATTTCTTTTAAAGGAGAAGATGTAAAACAAAATAGCACCCTTGTGAAAAAA
GGGACTGTTATTAATCCTGGAGTTGCAGCACTTCTTGCTACGTTTGGTTATAGTTCCGTACATGTTGTAAAACAGCCGAT
TATTGGAATAGTAACGACGGGTAGCGAACTGCTTGAAGTACATGAACAATTAAAGCTAGGGAAGATTCGAAATAGTAACT
CCTATATGATAGCAGCGCAAATTGAACGAGCGGGCGGAGTTGTACGGTATTATGGACAATTCGTTGACGATTTTGAGACG
TGTTATAACAATGTAAAAAAGGCGATAAAAGAAGTTGATATTTTAATTACGACTGGTGGCGTTTCAGTAGGAGACTATGA
CTATTTGCCTGCTATTTATGAGAGATTACAAGCTAATGTACTTTTTAACAAAATAGCGATGCGACCAGGAAGTGTGACAA
CTGTAGCTGAGGTAGAAGGAAAACTACTATTTGGTTTATCTGGTAATCCTTCAGCTTGTTATGTGGGTTGTGAATTATAT
GTTAGACCAGTCATTGGAACATACTTGCATAGGAAAGATTCGCACGTATTTCGTGCAGAGGCAATTTTACAAAAAGACTT
TCCGAAAGCAAATCCGTTTACTCGATTTGTAAGAGGGAGAGTAGAAATTGTAGATGGTCAATTGCAAGTTACACCAGTTG
GTTTAGATAAATCTAGCGCAATTTCTTCACTTGCAGAAGCGAATGCATTTATCGTTTTGCCAGGGGGAACGAGAGGATTT
AAAGCTGGAATTACTGTTTCGGTACTGTTATTAGAATCAACCAGCGGAAGTGAATGGCCATGGAAAGAATCGCTTCGTTC
ATACAAATAA

Upstream 100 bases:

>100_bases
TCATGGGACAAATGATGTGAAAATAGGAAAACGATTGTACACAAAATATATAGGATGAACAGAAAGAAAGTTTCTCCTTA
TTAAAACGAGGTGAAAAAGA

Downstream 100 bases:

>100_bases
TAGAAAAATAGGTTGCTAATTTATACAAAGATAAGAGGTGCGAAGTGACACATACGTATTATGAAGTAATTGATACACCT
ATATCAATTGAAGAAGTGAC

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLEKRIPIPVAEAVARVMEYAYQGEIEKVSLIESYGRTLGKDVIADHDVPHFNRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGFVFTEEVKAFQAVRIMTGAAIPRGCNAVIMLELTEEFEKNEKTYMKLKRSFASGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKLGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK

Sequences:

>Translated_429_residues
MLEKRIPIPVAEAVARVMEYAYQGEIEKVSLIESYGRTLGKDVIADHDVPHFNRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGFVFTEEVKAFQAVRIMTGAAIPRGCNAVIMLELTEEFEKNEKTYMKLKRSFASGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKLGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK
>Mature_429_residues
MLEKRIPIPVAEAVARVMEYAYQGEIEKVSLIESYGRTLGKDVIADHDVPHFNRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGFVFTEEVKAFQAVRIMTGAAIPRGCNAVIMLELTEEFEKNEKTYMKLKRSFASGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKLGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=31.6301703163017, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=31.6301703163017, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=30.46875, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147659, Length=365, Percent_Identity=30.1369863013699, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=24.2506811989101, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136978, Length=363, Percent_Identity=26.9972451790634, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24638841, Length=363, Percent_Identity=26.9972451790634, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47091; Mature: 47091

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRIPIPVAEAVARVMEYAYQGEIEKVSLIESYGRTLGKDVIADHDVPHFNRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGFVFTEEVKAFQAVRIMTGAAIPRGCNAVIMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEEFEKNEKTYMKLKRSFASGDNISFKGEDVKQNSTLVKKGTVINPGVAALLATFGYSSV
HHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEECCCEECCHHHHHHHHHCCCHH
HVVKQPIIGIVTTGSELLEVHEQLKLGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
EEECCCCEEEEECCHHHHHHHHHHHHCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCE
VEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLESTSGSEWP
EEEEECEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WKESLRSYK
HHHHHHCCC
>Mature Secondary Structure
MLEKRIPIPVAEAVARVMEYAYQGEIEKVSLIESYGRTLGKDVIADHDVPHFNRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGFVFTEEVKAFQAVRIMTGAAIPRGCNAVIMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEEFEKNEKTYMKLKRSFASGDNISFKGEDVKQNSTLVKKGTVINPGVAALLATFGYSSV
HHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEECCCEECCHHHHHHHHHCCCHH
HVVKQPIIGIVTTGSELLEVHEQLKLGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
EEECCCCEEEEECCHHHHHHHHHHHHCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCE
VEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLESTSGSEWP
EEEEECEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WKESLRSYK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]