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The map label for this gene is corC [H]

Identifier: 52143170

GI number: 52143170

Start: 2190371

End: 2191726

Strand: Direct

Name: corC [H]

Synonym: BCZK2068

Alternate gene names: 52143170

Gene position: 2190371-2191726 (Clockwise)

Preceding gene: 52143171

Following gene: 52143169

Centisome position: 41.32

GC content: 32.23

Gene sequence:

>1356_bases
TTGGACATATATAGTATAAGTATAGTGATTGTTTTAATTGCCTTAACGGCATTTTTCGTTGCAGCAGAGTTTGCAATTGT
TAAAGTACGAAGTTCACGAATTGACTATTTAATTGCAGAAGGAAATAATCGTGCAACATCTGTCAAAACAGTCATTACAA
ACTTAGACGAATATTTATCTGCTTGTCAGCTAGGAATAACAGTTACAGCACTGGGAATTGGTTGGTTTGGTAAACCAGCA
TTAAAGCAAATGTTTGACACGCTTTTTGTGAATTTGAACATTTCTACTCAACTGGCAGACATTTTTGCTGTAATTTTAGT
GTTTTTGTTTATTACATTTTTACATGTTGTAATAGGGGAATTGGCCCCAAAAACATTTGCGATTCAAAAAGCTGAGCAGG
TAAGTTTATTTGTTGCTAAACCGTTAACTTTCTTTTATCGTATGGCATTTCCATTTATTTGGCTATTAAATGGATCAGCC
CGAATTATTACGAAGTTGTTAGGGCTGAAACCACCGAAAGGGCACGATGAAGTTCATTCAGAAGAAGAATTACGGTTGTT
AGTTTCAGAAAGTTACAAAAATGGAGAGATTAATCAGTCTGAATATAAATATGTAAATAAAATCTTTGAATTTGATGATC
GTATAGCAAAAGAAATAATGGTACCCCGAACTGGGATGCATATTATAAGTAAAGAAATGCCTGCTGAAGAAGCTTTGCAA
AAGATGTCTCGGGAAAAATATACAAGATATCCAGTTGTTGATGGAGACAAAGATCACGTAATAGGCTTTGTGAACTTTAA
AGATATTTTTACAGATTTTGTGCAGCATAAAGCGGTTCGTAATAAGAAAGTAGAGCAATATATTAGGCCGATTATTTTAG
TTATTGACTCTATCCCAATACACGACTTATTTTTAAAAATGCAAAAACAAAGAACACATATTGCTATATTGATAGATGAA
TATGGTGGTACGTCTGGACTTGTTACTGTTGAAGACATTTTAGAAGAAATAGTTGGAGATATTCAAGATGAATTTGATAC
AGATGAACAGCCAGAAATTCAACGAGTTAGTGAAACGAAAACGATACTAGAGGGAAAAGTACTTGTTAGTGAAGTAAATA
CGTTATTAGGTTTAACAATAGATGATAATGGTGTTGATACAATTGGTGGATGGATTTTAACGAAAAATATAGAAATTGCT
GAAGAGGATTTCATTGAAATCGAAAATTATAAGTTTTGCGTGAAAGAATTAGATGGACACTATATAAAGAGACTAGAAGT
TACAAAAACTATAGAATCAATTGTTATTTTAGAAGATGAAAAACAAATTTCATTACAAGAACAAATTAGTTCGTAG

Upstream 100 bases:

>100_bases
TAATGTAGAATTTTGTTAGAGTATTAGAATGCTTACTTCACTTGAATAAAATTAAGTAGGAGGTGGCTTCCTTGCTTACA
ATGTAAGTAAGGAAAAGTAT

Downstream 100 bases:

>100_bases
ACTCTGCTAGATGGCAGAGTTTTTTTGAGCATAATGTTTTTGGCAAAATAAGGGCTATGTTACAATGGAATAAGTCAGAC
CTTTCACTAGGTGAAGTATT

Product: magnesium and cobalt efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDIYSISIVIVLIALTAFFVAAEFAIVKVRSSRIDYLIAEGNNRATSVKTVITNLDEYLSACQLGITVTALGIGWFGKPA
LKQMFDTLFVNLNISTQLADIFAVILVFLFITFLHVVIGELAPKTFAIQKAEQVSLFVAKPLTFFYRMAFPFIWLLNGSA
RIITKLLGLKPPKGHDEVHSEEELRLLVSESYKNGEINQSEYKYVNKIFEFDDRIAKEIMVPRTGMHIISKEMPAEEALQ
KMSREKYTRYPVVDGDKDHVIGFVNFKDIFTDFVQHKAVRNKKVEQYIRPIILVIDSIPIHDLFLKMQKQRTHIAILIDE
YGGTSGLVTVEDILEEIVGDIQDEFDTDEQPEIQRVSETKTILEGKVLVSEVNTLLGLTIDDNGVDTIGGWILTKNIEIA
EEDFIEIENYKFCVKELDGHYIKRLEVTKTIESIVILEDEKQISLQEQISS

Sequences:

>Translated_451_residues
MDIYSISIVIVLIALTAFFVAAEFAIVKVRSSRIDYLIAEGNNRATSVKTVITNLDEYLSACQLGITVTALGIGWFGKPA
LKQMFDTLFVNLNISTQLADIFAVILVFLFITFLHVVIGELAPKTFAIQKAEQVSLFVAKPLTFFYRMAFPFIWLLNGSA
RIITKLLGLKPPKGHDEVHSEEELRLLVSESYKNGEINQSEYKYVNKIFEFDDRIAKEIMVPRTGMHIISKEMPAEEALQ
KMSREKYTRYPVVDGDKDHVIGFVNFKDIFTDFVQHKAVRNKKVEQYIRPIILVIDSIPIHDLFLKMQKQRTHIAILIDE
YGGTSGLVTVEDILEEIVGDIQDEFDTDEQPEIQRVSETKTILEGKVLVSEVNTLLGLTIDDNGVDTIGGWILTKNIEIA
EEDFIEIENYKFCVKELDGHYIKRLEVTKTIESIVILEDEKQISLQEQISS
>Mature_451_residues
MDIYSISIVIVLIALTAFFVAAEFAIVKVRSSRIDYLIAEGNNRATSVKTVITNLDEYLSACQLGITVTALGIGWFGKPA
LKQMFDTLFVNLNISTQLADIFAVILVFLFITFLHVVIGELAPKTFAIQKAEQVSLFVAKPLTFFYRMAFPFIWLLNGSA
RIITKLLGLKPPKGHDEVHSEEELRLLVSESYKNGEINQSEYKYVNKIFEFDDRIAKEIMVPRTGMHIISKEMPAEEALQ
KMSREKYTRYPVVDGDKDHVIGFVNFKDIFTDFVQHKAVRNKKVEQYIRPIILVIDSIPIHDLFLKMQKQRTHIAILIDE
YGGTSGLVTVEDILEEIVGDIQDEFDTDEQPEIQRVSETKTILEGKVLVSEVNTLLGLTIDDNGVDTIGGWILTKNIEIA
EEDFIEIENYKFCVKELDGHYIKRLEVTKTIESIVILEDEKQISLQEQISS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=405, Percent_Identity=45.1851851851852, Blast_Score=376, Evalue=1e-104,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=24.7086247086247, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI145693175, Length=418, Percent_Identity=23.444976076555, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786879, Length=254, Percent_Identity=30.3149606299213, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87082033, Length=236, Percent_Identity=23.3050847457627, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788119, Length=237, Percent_Identity=22.3628691983122, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 51281; Mature: 51281

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIYSISIVIVLIALTAFFVAAEFAIVKVRSSRIDYLIAEGNNRATSVKTVITNLDEYLS
CCEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHH
ACQLGITVTALGIGWFGKPALKQMFDTLFVNLNISTQLADIFAVILVFLFITFLHVVIGE
HHHHCEEEEEEECCCCCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPKTFAIQKAEQVSLFVAKPLTFFYRMAFPFIWLLNGSARIITKLLGLKPPKGHDEVHS
HCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCCCCC
EEELRLLVSESYKNGEINQSEYKYVNKIFEFDDRIAKEIMVPRTGMHIISKEMPAEEALQ
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHH
KMSREKYTRYPVVDGDKDHVIGFVNFKDIFTDFVQHKAVRNKKVEQYIRPIILVIDSIPI
HHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
HDLFLKMQKQRTHIAILIDEYGGTSGLVTVEDILEEIVGDIQDEFDTDEQPEIQRVSETK
HHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TILEGKVLVSEVNTLLGLTIDDNGVDTIGGWILTKNIEIAEEDFIEIENYKFCVKELDGH
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEECCCEECHHHHEECCCHHHHHHHHCCH
YIKRLEVTKTIESIVILEDEKQISLQEQISS
HHHHHHHHHHHHHEEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MDIYSISIVIVLIALTAFFVAAEFAIVKVRSSRIDYLIAEGNNRATSVKTVITNLDEYLS
CCEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHH
ACQLGITVTALGIGWFGKPALKQMFDTLFVNLNISTQLADIFAVILVFLFITFLHVVIGE
HHHHCEEEEEEECCCCCCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPKTFAIQKAEQVSLFVAKPLTFFYRMAFPFIWLLNGSARIITKLLGLKPPKGHDEVHS
HCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCCCCC
EEELRLLVSESYKNGEINQSEYKYVNKIFEFDDRIAKEIMVPRTGMHIISKEMPAEEALQ
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHH
KMSREKYTRYPVVDGDKDHVIGFVNFKDIFTDFVQHKAVRNKKVEQYIRPIILVIDSIPI
HHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
HDLFLKMQKQRTHIAILIDEYGGTSGLVTVEDILEEIVGDIQDEFDTDEQPEIQRVSETK
HHHHHHHHHCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
TILEGKVLVSEVNTLLGLTIDDNGVDTIGGWILTKNIEIAEEDFIEIENYKFCVKELDGH
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEECCCEECHHHHEECCCHHHHHHHHCCH
YIKRLEVTKTIESIVILEDEKQISLQEQISS
HHHHHHHHHHHHHEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]