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The map label for this gene is hemY [H]

Identifier: 52143067

GI number: 52143067

Start: 2301910

End: 2303310

Strand: Direct

Name: hemY [H]

Synonym: BCZK2172

Alternate gene names: 52143067

Gene position: 2301910-2303310 (Clockwise)

Preceding gene: 52143066

Following gene: 52143064

Centisome position: 43.42

GC content: 33.05

Gene sequence:

>1401_bases
ATGAAAACGGTTGTTGTTATCGGTGGAGGTATTACAGGACTTTCCACTATGTTTTATTTAGAGAAATTAAAAAAGGATTA
TAATATTGATTTGAATTTAATTCTTGTAGAAAAAGAAGAGTACTTAGGTGGTAAAATCCATAGTGTAGAAGAAAAGGATT
TTATTATGGAATCAGGAGCGGATTCTATTGTTGCACGTAATGAACATGTTATGCCACTTGTAAAAGATTTAAATTTAGAA
GAAGAAATGGTATATAACGAAACGGGTATTTCTTACATATATTCTGATAATACTTTACATCCAATTCCTTCTGACACTAT
ATTTGGGATACCGATGAGCGCCCGATCGTTGTTTAGCAGTACGCTAGTATCAACGAAGGGGAAAATTATTGCTTTAAAGG
ATTTTATAACGAAAAATAAAGATTTTACGAAAGATACATCACTTGCTGTATTTTTAGAAAGCTTCTTAGGGAAAGAGTTA
GTGGAAAGACAAATTGCGCCGGTGCTTTCAGGTGTATATTCGGGTAAATTGAACGAGCTTACAATGGCATCGACATTACC
GTATTTACTGGACTATAAAAATAAATATGGAAGTATTATTAAAGGTTTTGAAGAGAATAAAAAACAGTTTCAATCAGCAG
GAAACAAAAAGTTCGTATCATTTAAAGGTGGATTATCTACGATTATTGATCGTTTAGAAGAAGTGCTGACTGAGACGGTT
GTTAAGAAGGGTGCTGTAACGACAGCTGTAAGCAAACAAGGTGATCGCTATGAGATCTCCTTTGCAAATCACGAATCAAT
CCAAACTGATTATGTTGTTTTAGCAACTCCGCATAATATCGCAGAAACTTTATTACAGTCTAATGAGTTAAACGAGCAGT
TTCATACATTTAAAAATTCATCACTTATAAGTATTTACTTAGGATTTGACATACTAGATGAACAATTACCGGCGGACGGC
ACAGGATTTATTGTAACAGAAAACAGTGATTTACATTGTGATGCTTGCACATGGACAAGCCGGAAATGGAAACATACATC
TGGAAAACAAAAACTATTAGTGAGAATGTTTTATAAGAGTACTAATCCAGTATATGAAACGATTAAAAATTATAATGAAG
AAGAATTAGTACGGGTTGCTTTATATGATATTGAAAAGAGTCTCGGAATTAAAGGTGAACCAGAAGTAGTTGAAGTGACA
AATTGGAAAGATTTAATGCCGAAATATCATTTAGAACATAATCAAGCGGTTCAAACATTACAAGAAAAAATGATGAATCT
TTACCCGAATATATACTTAGCTGGCGCTTCCTATTATGGTGTTGGTATTGGTGCGTGTATTGGAAATGGAAAAAACATTG
CAAATGAAATCATTGCAACATTAAATGAACCATCAAATTAA

Upstream 100 bases:

>100_bases
TAATTTCTTACAGAATGCGCAAGTTGCTAGTCGAATATAAGGAATTTTGGGTATAATAATAAAGGAATTATTAATTGTAT
CGGTTAGGAGCGCAGCACAT

Downstream 100 bases:

>100_bases
TATAGAATAAATAAAATGTCCCACCATTATAACGGAGGGACATTTTATTTATTTTACTTGAATTGAGACTTTTTTGTTAG
TTGTATTATTCTCGGTAATT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
EEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSARSLFSSTLVSTKGKIIALKDFITKNKDFTKDTSLAVFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEVLTETV
VKKGAVTTAVSKQGDRYEISFANHESIQTDYVVLATPHNIAETLLQSNELNEQFHTFKNSSLISIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYNEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQAVQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN

Sequences:

>Translated_466_residues
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
EEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSARSLFSSTLVSTKGKIIALKDFITKNKDFTKDTSLAVFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEVLTETV
VKKGAVTTAVSKQGDRYEISFANHESIQTDYVVLATPHNIAETLLQSNELNEQFHTFKNSSLISIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYNEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQAVQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
>Mature_466_residues
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLE
EEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSARSLFSSTLVSTKGKIIALKDFITKNKDFTKDTSLAVFLESFLGKEL
VERQIAPVLSGVYSGKLNELTMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEVLTETV
VKKGAVTTAVSKQGDRYEISFANHESIQTDYVVLATPHNIAETLLQSNELNEQFHTFKNSSLISIYLGFDILDEQLPADG
TGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKSTNPVYETIKNYNEEELVRVALYDIEKSLGIKGEPEVVEVT
NWKDLMPKYHLEHNQAVQTLQEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=492, Percent_Identity=24.5934959349593, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI4506001, Length=492, Percent_Identity=24.5934959349593, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24649745, Length=475, Percent_Identity=23.7894736842105, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52244; Mature: 52244

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGA
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHCCCCEECCCHHHHHHHCCC
DSIVARNEHVMPLVKDLNLEEEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSARSLFSS
CCEEECCCCCCHHHHHCCCCHHHEECCCCCEEEEECCEECCCCCCCEEECCHHHHHHHHH
TLVSTKGKIIALKDFITKNKDFTKDTSLAVFLESFLGKELVERQIAPVLSGVYSGKLNEL
HHHHCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
TMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEVLTETV
EHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VKKGAVTTAVSKQGDRYEISFANHESIQTDYVVLATPHNIAETLLQSNELNEQFHTFKNS
HHCCCCEEHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCC
SLISIYLGFDILDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKS
CEEEEEECCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
TNPVYETIKNYNEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQAVQTL
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCCCCHHHHHHHH
QEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
HHHHHHHCCCEEEECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKTVVVIGGGITGLSTMFYLEKLKKDYNIDLNLILVEKEEYLGGKIHSVEEKDFIMESGA
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHCCCCEECCCHHHHHHHCCC
DSIVARNEHVMPLVKDLNLEEEMVYNETGISYIYSDNTLHPIPSDTIFGIPMSARSLFSS
CCEEECCCCCCHHHHHCCCCHHHEECCCCCEEEEECCEECCCCCCCEEECCHHHHHHHHH
TLVSTKGKIIALKDFITKNKDFTKDTSLAVFLESFLGKELVERQIAPVLSGVYSGKLNEL
HHHHCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
TMASTLPYLLDYKNKYGSIIKGFEENKKQFQSAGNKKFVSFKGGLSTIIDRLEEVLTETV
EHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
VKKGAVTTAVSKQGDRYEISFANHESIQTDYVVLATPHNIAETLLQSNELNEQFHTFKNS
HHCCCCEEHHHCCCCEEEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCC
SLISIYLGFDILDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLVRMFYKS
CEEEEEECCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHC
TNPVYETIKNYNEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQAVQTL
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHCCCCCCCHHHHHHHH
QEKMMNLYPNIYLAGASYYGVGIGACIGNGKNIANEIIATLNEPSN
HHHHHHHCCCEEEECCCCCCCEEEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]