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The map label for this gene is cynR [H]

Identifier: 52143051

GI number: 52143051

Start: 2315246

End: 2316148

Strand: Reverse

Name: cynR [H]

Synonym: BCZK2188

Alternate gene names: 52143051

Gene position: 2316148-2315246 (Counterclockwise)

Preceding gene: 52143044

Following gene: 52143055

Centisome position: 43.69

GC content: 30.12

Gene sequence:

>903_bases
GTGATCCAAATCGAATTACGACAACTTGAATATTTTTTAGCTGTTTCAAAAGAATTGCATTTCACAAAAGCAGCTGAGAA
ATTAAATATTTCACAGCCTTCACTTAGTCAGCAAATACGTGCATTAGAACATGAAGTTGGAATGCCTCTTTTCGATCGAA
TTGGTAAAAAAATATCTTTAACCGAAGCTGGGAGGATTTTATTATTACATAGTGAAACAATTTTTCATGAAGTTGAACAA
GCCCGTTCTGCTATTCAAGATTTAAACGGATTACAACAAGGTTCCTTAACAATTGGATCATTATTAACCGTCGTAAATTA
CTTACTACCACCAGCTATTTTAAATTTTAATAATTTATATCCCAATATAGAACTTTCTGTATTAGGACTTCGCACAGGAG
ATATTCGTGAAAAATTATTACAAAACGAACTAAATATTGGCATTACATTTCTACCGGTGCAAGATAAAGAAATTATTTCT
ACCCCTCTCTACAAAAGTGAACTTATAATAGTCGTACCAACTGGTCATCAATTAGCTGAACATAATCATGTATCTATTGC
TGAATTGCAGAATTACCCTTTAATTCTTTTACCTAAAAATTTCTTTTTAACCGAATTAATTACATCCCATTGTCAAAAAT
TCAACTTTAAGCCAAAACCGATTTTAGAAATTAGTACAATGGAATCTTTAATCCAAATGGTTTCAAAAGGCATGGGAATT
ACAGTTTTACCAAAACCGTATATAGACTTTTTACAAAATAAAAACATTCAAGCTATTAAAATAGAAAATCCTACTCCAAC
AATAGAAATAGGGCTTATTTATAGAAAAGATAAATATATGTGTGCTGCAACTCGAGAATTTATTAAACAATTGAAACTAA
CCGTACATTCTTTACAAAATTAA

Upstream 100 bases:

>100_bases
TATCTCTTTTATATAAAGATGATTATAAAACCTAAAAAATCATTGTTCAATCCAATTATTTATATAATAATAATAGGTAA
AACCTATTATTGTACTTGAG

Downstream 100 bases:

>100_bases
ACGAACAAAAGAGATTATCCTATGAAGTCATTTCATAACGACCTAGTAGAATAATCTCTTTTCATAATGAAATAAAGTAT
TAACTATAAATTTCAGTGTA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRALEHEVGMPLFDRIGKKISLTEAGRILLLHSETIFHEVEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELNIGITFLPVQDKEIIS
TPLYKSELIIVVPTGHQLAEHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN

Sequences:

>Translated_300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRALEHEVGMPLFDRIGKKISLTEAGRILLLHSETIFHEVEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELNIGITFLPVQDKEIIS
TPLYKSELIIVVPTGHQLAEHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
>Mature_300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRALEHEVGMPLFDRIGKKISLTEAGRILLLHSETIFHEVEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELNIGITFLPVQDKEIIS
TPLYKSELIIVVPTGHQLAEHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=282, Percent_Identity=33.6879432624113, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=29.616724738676, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788887, Length=291, Percent_Identity=30.9278350515464, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787879, Length=294, Percent_Identity=30.2721088435374, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790399, Length=273, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=28.740157480315, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=30.1694915254237, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787806, Length=274, Percent_Identity=25.1824817518248, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787530, Length=293, Percent_Identity=23.8907849829352, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787601, Length=306, Percent_Identity=24.8366013071895, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=24.2214532871972, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=27.2357723577236, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789204, Length=258, Percent_Identity=26.3565891472868, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=244, Percent_Identity=23.7704918032787, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=25.8620689655172, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082132, Length=242, Percent_Identity=23.5537190082645, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790262, Length=257, Percent_Identity=25.6809338521401, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789173, Length=145, Percent_Identity=31.0344827586207, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87081904, Length=296, Percent_Identity=24.3243243243243, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790783, Length=252, Percent_Identity=26.984126984127, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786401, Length=292, Percent_Identity=22.6027397260274, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787589, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=247, Percent_Identity=24.2914979757085, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787128, Length=300, Percent_Identity=21.6666666666667, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788626, Length=244, Percent_Identity=26.2295081967213, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34056; Mature: 34056

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRALEHEVGMPLFDRIGKKISL
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEEEE
TEAGRILLLHSETIFHEVEQARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLY
ECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCC
PNIELSVLGLRTGDIREKLLQNELNIGITFLPVQDKEIISTPLYKSELIIVVPTGHQLAE
CCEEEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCCCCCEEEEEECCCHHHC
HNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
CCCEEHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCE
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
EECCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRALEHEVGMPLFDRIGKKISL
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHCCCEEEE
TEAGRILLLHSETIFHEVEQARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLY
ECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCC
PNIELSVLGLRTGDIREKLLQNELNIGITFLPVQDKEIISTPLYKSELIIVVPTGHQLAE
CCEEEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCCCCCEEEEEECCCHHHC
HNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
CCCEEHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCE
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
EECCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]