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The map label for this gene is ipdC [H]

Identifier: 52143006

GI number: 52143006

Start: 2361116

End: 2362801

Strand: Reverse

Name: ipdC [H]

Synonym: BCZK2232

Alternate gene names: 52143006

Gene position: 2362801-2361116 (Counterclockwise)

Preceding gene: 52143002

Following gene: 52143011

Centisome position: 44.57

GC content: 34.7

Gene sequence:

>1686_bases
ATGATTCACTTGAAAACTCAATATACTGTAAGTACATATTTATTAGACCGACTAAGCGAATTAGGAATTGAGCATATTTT
TGGTGTCCCTGGTGATTATAATTTGGCTTTTTTAGATGATGTACTCGCACATAAAAATTTAGAGTGGATTGGCAATTGTA
ATGAATTAAATGCGGCATATGCTGCAGATGGATATGCTCGTATAAAAGGAATCGGTGCTCTTATTACCACCTTTGGCGTT
GGAGAATTAAGTGCCATTAACGGAATTGCTGGTTCATATGCTGAAAATGTACCCGTTATAAAAATAACAGGTACGCCAAC
AACAACTGTAATGGAAAATGGGGAGCTCGTTCATCATACGTTAGGCGACGGAAAGTTTAATCACTTTTCCAATATGTATC
GGGAAATTACTGTTGCACAAACTAATTTAACCCCAGAGCATGCAGTCGAAGAAATTGACCGTGTGTTACGTGCATGTTGG
AATGAAAAACGTCCTGTTCATATTAATTTACCTATTGATGTGTATAATAAACCAATTAATAAACCTGCAGAACCAATTTT
ACATAAACCGATTTTAAGTAATAAAGAAACAATGGATAAAATGCTTCTACATGCCATTTCAAAAATAAATAGCGCAAAGA
AACCTATTATTTTAGCGGATTTTGAAGTAGATCGTTTTCATGCAAAAGAATATTTATATCAATTTGTAGAAAAAACAGGG
TTTCCTATTGCAACGTTAAGTATGGGAAAAGGAATATTTCCAGAAAAACACCCTCAATTTATAGGGATTTATACTGGTGA
TGTAAGTTTTCCATACTTGCGTAAAAGAATTGATGAATCTGACTGTATTATTAGTATTGGTGTGAAGTTAACTGATACTA
TTACAGGTGGCTTCACACAAGGTTTTACGAAAGAACAAGTTATTGAAATTCATCCCTACACTGTGAAAATTACAGATAAA
AAATACGGGCCAGTTGTAATGAAAGATGTTTTACAACAGTTAAGTGATATAATTAAGCATCGAAATGAAGAAACGCTTGA
TATTAAGCCATTTATTTCAGAATCGCTATCTATGACAGAAGAGTTCAATCCAAAAGCACACATGGTTACACAAAAACGTT
TTTGGCAACAAATATACCATTTCTTACAAGAAAACGACGTCTTACTTGCAGAGCAAGGAACACCTTTCTTTGGTAGTGCC
GCTATCCCTTTACCAAACAACACTACATATGTAGCGCAACCATTATGGGGATCGATCGGCTATACATTACCTGCTCTACT
TGGTACACAGCTCGCTAATTTATCGCGGCGCAACATTTTAATTATTGGTGATGGTTCTTTCCAATTAACTGTCCAAGAGT
TATCGACCATGCTTCGTCAAAATTTAAAACCGATTATATTTTTAATTAATAACAATGGTTATACTGTTGAACGTGCAATT
CATGGTCAAAACGAACCGTATAATGACATACAAATGTGGGAGTACACAAAACTAGCGAACGTATTCGGAACAGAAGAAAA
AAGCCAAACATTTAAAGTAGAAAATGAAACAGAGTTACAAGAAGTCTTAACTAAAATAAGTATTGATAAGGATCAACTTA
CCTTTGTTGAAGTTGTAATGAGCCAAGGTGATCAGCCTGAACTGCTAGCTAAACTTGGGAAAAGATTCGGCCAACAAAAT
TCTTAA

Upstream 100 bases:

>100_bases
TCCCCCTGTATGTAAATTATACCACATTCTAGTAATGAATATTTTAATCAATACTCTAGAGCTGCTTTCGTTTATTACAA
GAAAGCAAAACGATTAGGAG

Downstream 100 bases:

>100_bases
TATAAAAAGCATAACCTAATTATATAAAAGGAAAAGGATGGAAAGTTCCACCCTTTTCCTTTTATATATACTATTTTAAG
AACCTTCTTCGACTAACGTC

Product: indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVLAHKNLEWIGNCNELNAAYAADGYARIKGIGALITTFGV
GELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINKPAEPILHKPILSNKETMDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSFPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDIIKHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S

Sequences:

>Translated_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVLAHKNLEWIGNCNELNAAYAADGYARIKGIGALITTFGV
GELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINKPAEPILHKPILSNKETMDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSFPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDIIKHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S
>Mature_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVLAHKNLEWIGNCNELNAAYAADGYARIKGIGALITTFGV
GELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHTLGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINKPAEPILHKPILSNKETMDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSFPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDIIKHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=550, Percent_Identity=22.7272727272727, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=21.8348623853211, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786717, Length=480, Percent_Identity=23.9583333333333, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787096, Length=553, Percent_Identity=21.6998191681736, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=25.8264462809917, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=25.8264462809917, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=571, Percent_Identity=39.7548161120841, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6323073, Length=571, Percent_Identity=38.7040280210158, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321524, Length=577, Percent_Identity=37.261698440208, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320123, Length=559, Percent_Identity=35.778175313059, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320588, Length=595, Percent_Identity=30.0840336134454, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323755, Length=307, Percent_Identity=22.1498371335505, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 63278; Mature: 63278

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVLAHKNLEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCHHH
AADGYARIKGIGALITTFGVGELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCCEEEEECCCCEEEEECCCEEEEE
LGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPIN
CCCCCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCC
KPAEPILHKPILSNKETMDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGIYTGDVSFPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCC
GFTKEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDIIKHRNEETLDIKPFISESLSMTE
CCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
EFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNNTTYVAQPLWGSIG
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCEEEECCCCCHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHH
SQGDQPELLAKLGKRFGQQNS
HCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVLAHKNLEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCHHH
AADGYARIKGIGALITTFGVGELSAINGIAGSYAENVPVIKITGTPTTTVMENGELVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCCEEEEECCCCEEEEECCCEEEEE
LGDGKFNHFSNMYREITVAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPIN
CCCCCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCC
KPAEPILHKPILSNKETMDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGIYTGDVSFPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCC
GFTKEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDIIKHRNEETLDIKPFISESLSMTE
CCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
EFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGTPFFGSAAIPLPNNTTYVAQPLWGSIG
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCEEEECCCCCHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTMLRQNLKPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWEYTKLANVFGTEEKSQTFKVENETELQEVLTKISIDKDQLTFVEVVM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHH
SQGDQPELLAKLGKRFGQQNS
HCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]