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The map label for this gene is pbp2 [H]

Identifier: 52142994

GI number: 52142994

Start: 2372096

End: 2373862

Strand: Reverse

Name: pbp2 [H]

Synonym: BCZK2245

Alternate gene names: 52142994

Gene position: 2373862-2372096 (Counterclockwise)

Preceding gene: 52142991

Following gene: 52142998

Centisome position: 44.78

GC content: 33.16

Gene sequence:

>1767_bases
ATGTTACATACAAAAATAAAAAAATGGGGATTTTTTGCGGTTCTTTCTATTGTAGGTTTGATTTTACTAATTCTATTTAA
AATCAACTTCATTTCAATTACTATCGCAACTTCTTCAGCCGAAAGAGGAAAAATCTTTGATCAAAATGGTGTAATACTAG
CTACAAATAAGAAAGTTAAGTCTCTATATTGTACTTCTAATGATGAAAAGCTATCGAAACAAGATACATCAAACACATTA
GCTTTTTTCGACCAATTTTCAAGTAAGTTTCAACATGATATTTCTTCAGAGAGCATAAAATCTCAATTACAACAATCTTG
TAAAAAACAGACTATGCATGATATACCGTTATACTCTGATATAGCTGAGAATGAACTTGCATTCATAAACAAAAACAAAC
CGAATAATGTAATAATTAAAGATGAATGGGTTCGATATTATCCTAAACATGAAATTGGTTCACAGGTAATTGGGTATGTA
GAAAATAACCTTAATTCAAAGCATATGCCGGTTGGAAAAAGTGGGATTGAGCTGCAATATGAAGATGATTTAAAAGGAAA
ACCGGGTAAAACTCTTATTTTTAAAATGAATAATAAAGAGTTCTTATGGAACATTCAAAAAGTACAAAAAGGTAAGGATA
TCAGGCTAGCTTTAGATTCTAAATTGCAACAAAAATCAGAGGAAGCATTACGATCGCAAATTAAGAAATTACCTGATGCT
AAAGCTGGTTATGCTGTAGTGAGTGATGCAAAAACTGGCGCAATTTTAACTATGGCCAACTCAGCAGTTTTTGATCCAAA
TATATTACATACTCATGTATCAACTAAAATAGATAACTTAAAATCACTTTCGCAAAATAAAGCAATTCAAAAATTAAAGT
ATGGTGAATCTTATATAAATATGGCCTCTACTATAAAACCACTTACTATTTTAATTGGATTAAACGAAAAACTTTTTCAA
CCTGAAGATACTTATCTAGATAAAGGTACTTTTCAGTATGATAATCAGAATAACATTACAAATGCACCTGGAACACCTAC
AGGTGAGATTACACCGAGGCAAGCTATCATTAATTCGTCTAACACATTTATGACAGCAAAAGTAGCTCTTCCATTATTTA
ACCAACATAATGGCAATGTAGAAAAAGTGGCACATATATGGACAGATTATTTAATGCAATTCGGCCTACGTTCTAAAACC
GGGATTGATTTACCCTTTGAAGAAGACGGACACTATGAATTCCACCCTTCCAATAAGTTTGAAAATGGAATCTCCGCTTT
ATTAAATGCTTCGTGGGGCGGAAACGAAGTGCATACTCCGCTTCAACTCGCTCAATATGCAGCAACTTTAGCAAGTAAAG
GTGATAAATATAAACCTCAAATCGTAAGTGCTATTATTGGGCCGGATGGTAAGGAAACAAAAAAGTTTAAACCAATTTTA
GAAAGTTCAAATCGTTACCCGACGAACTTTTGGAGTGTTGTGCAAGGTGGAATGAGTCAAAATATAGAGGAGATTAAAAA
GTTGCCCTTTGACGTCGCTGGTAAAACAGGTATTACAGGTTTTCCGAATGAGCAAGCAAGAATGATAAATCATTCTCTAT
TCATTGCATATGCTCCTACCGAAGATCCACAGATTGCCGTTTCTGTCGTTATTCCTGGAAGTAATTCAGAAAAAAACATT
GCTGCTCTCGTTACATCAGAAATTTTACAGTCCTGGAATACGCTTCAAAAAGAGAATACAAACAAAAAGGAAGGTTCATT
AAAGTGA

Upstream 100 bases:

>100_bases
CTGTAGTACTTAATAGACAATCTAAATAATAAAGTTGTTCCACATTTACAAAAAAAATAATTAACTATAAGATGAAGTAG
GCTACAAAAGGGAGGATTTT

Downstream 100 bases:

>100_bases
ACCTTCCTTTTTTACCAAATAGAATCTATACTTATTATTTTCCATTCACCTTCATTATTCTTTTCAAACATAAAAGAGTA
TTTAATGTCAGTTAAAACAT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWVRYYPKHEIGSQVIGYV
ENNLNSKHMPVGKSGIELQYEDDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KAGYAVVSDAKTGAILTMANSAVFDPNILHTHVSTKIDNLKSLSQNKAIQKLKYGESYINMASTIKPLTILIGLNEKLFQ
PEDTYLDKGTFQYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGHYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGPDGKETKKFKPIL
ESSNRYPTNFWSVVQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILQSWNTLQKENTNKKEGSLK

Sequences:

>Translated_588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWVRYYPKHEIGSQVIGYV
ENNLNSKHMPVGKSGIELQYEDDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KAGYAVVSDAKTGAILTMANSAVFDPNILHTHVSTKIDNLKSLSQNKAIQKLKYGESYINMASTIKPLTILIGLNEKLFQ
PEDTYLDKGTFQYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGHYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGPDGKETKKFKPIL
ESSNRYPTNFWSVVQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILQSWNTLQKENTNKKEGSLK
>Mature_588_residues
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVKSLYCTSNDEKLSKQDTSNTL
AFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSDIAENELAFINKNKPNNVIIKDEWVRYYPKHEIGSQVIGYV
ENNLNSKHMPVGKSGIELQYEDDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
KAGYAVVSDAKTGAILTMANSAVFDPNILHTHVSTKIDNLKSLSQNKAIQKLKYGESYINMASTIKPLTILIGLNEKLFQ
PEDTYLDKGTFQYDNQNNITNAPGTPTGEITPRQAIINSSNTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKT
GIDLPFEEDGHYEFHPSNKFENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGPDGKETKKFKPIL
ESSNRYPTNFWSVVQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPTEDPQIAVSVVIPGSNSEKNI
AALVTSEILQSWNTLQKENTNKKEGSLK

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=624, Percent_Identity=21.474358974359, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786272, Length=554, Percent_Identity=24.7292418772563, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65673; Mature: 65673

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCEECCCCEEEEECCCEE
SLYCTSNDEKLSKQDTSNTLAFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSD
EEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
IAENELAFINKNKPNNVIIKDEWVRYYPKHEIGSQVIGYVENNLNSKHMPVGKSGIELQY
HCCCCEEEEECCCCCEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
EDDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
CCCCCCCCCCEEEEEECCCCEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
KAGYAVVSDAKTGAILTMANSAVFDPNILHTHVSTKIDNLKSLSQNKAIQKLKYGESYIN
CCCEEEEECCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MASTIKPLTILIGLNEKLFQPEDTYLDKGTFQYDNQNNITNAPGTPTGEITPRQAIINSS
HHHCCCEEEEEEECCHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHCCCC
NTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKTGIDLPFEEDGHYEFHPSNKF
CCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCH
ENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGPDGKETKKFKPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHEECCCCCCHHHHHHHH
ESSNRYPTNFWSVVQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPT
HCCCCCCCHHHHHHHCHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
EDPQIAVSVVIPGSNSEKNIAALVTSEILQSWNTLQKENTNKKEGSLK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLHTKIKKWGFFAVLSIVGLILLILFKINFISITIATSSAERGKIFDQNGVILATNKKVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCEECCCCEEEEECCCEE
SLYCTSNDEKLSKQDTSNTLAFFDQFSSKFQHDISSESIKSQLQQSCKKQTMHDIPLYSD
EEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
IAENELAFINKNKPNNVIIKDEWVRYYPKHEIGSQVIGYVENNLNSKHMPVGKSGIELQY
HCCCCEEEEECCCCCEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
EDDLKGKPGKTLIFKMNNKEFLWNIQKVQKGKDIRLALDSKLQQKSEEALRSQIKKLPDA
CCCCCCCCCCEEEEEECCCCEEEEHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
KAGYAVVSDAKTGAILTMANSAVFDPNILHTHVSTKIDNLKSLSQNKAIQKLKYGESYIN
CCCEEEEECCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MASTIKPLTILIGLNEKLFQPEDTYLDKGTFQYDNQNNITNAPGTPTGEITPRQAIINSS
HHHCCCEEEEEEECCHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHCCCC
NTFMTAKVALPLFNQHNGNVEKVAHIWTDYLMQFGLRSKTGIDLPFEEDGHYEFHPSNKF
CCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCH
ENGISALLNASWGGNEVHTPLQLAQYAATLASKGDKYKPQIVSAIIGPDGKETKKFKPIL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHEECCCCCCHHHHHHHH
ESSNRYPTNFWSVVQGGMSQNIEEIKKLPFDVAGKTGITGFPNEQARMINHSLFIAYAPT
HCCCCCCCHHHHHHHCHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEEEECCC
EDPQIAVSVVIPGSNSEKNIAALVTSEILQSWNTLQKENTNKKEGSLK
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]