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The map label for this gene is fes [H]

Identifier: 52142805

GI number: 52142805

Start: 2572390

End: 2574015

Strand: Reverse

Name: fes [H]

Synonym: BCZK2435

Alternate gene names: 52142805

Gene position: 2574015-2572390 (Counterclockwise)

Preceding gene: 52142804

Following gene: 52142807

Centisome position: 48.56

GC content: 32.47

Gene sequence:

>1626_bases
GTGACTACAATAATCAGTCCTACGTTAGAGAAGCTTAAAAATCAATTAAAGAATGGAAACGAAAAAGCTCTTTATACTTT
TTTGGATGAAATCAAGTCAAATCATACACCACTTGTAGAACAATGTCCTATAGATAATCAGTATAAACTTATAACGTATA
TATGGTTAGGTGATCAAAATACTGAAAATGTTTATGTAGTCGGTAGTTTTCCTGGTTGGGATCTGTCTGTAAATCAATTA
CAACGATTGTTACAGACAGATATTTGGTATGTTACGTTTAGGACGAATAAGAGGTTCATTTCAACTTATTATTTTACAGT
AAATGATTTTTTCAAAAATGATTGGATAAAGCGTAGTGAACAGTACCGACTAGACCCATTCAATGAAAATGTATTTGGAG
AAGGTGCCAATAAAGCGTCTGTGTTAAAAATAGATATGGAAGTGCAGTATAGCAGTCGTTTTCCTTCAAATCATTATCCA
TCCGGAAAGATTGAAACATATTCTTTTTATAGTTCGATTTTAAATAACACACGTAAACTTCATATTTATACGCCTCATGA
TTATTCTCACACTTCACACCTTCAAGAACTTCTCATTGTATTTGATGGGAATTCATTCATTAATGACCTTTCAATCACAA
AAACACTTAATTATTTAATTTATGAAAAAGAAATCCCATCGTGTATTGCTGTTGCTATAGATCCTGTTGAGCGATTAGAA
GAGCTAACTTATAACGATAAAATGAATACATTTTTAACGAAGGAATTACTTCCATGGATTCAAACTAAATATCATGTGTA
TCAAAAAGCAAAACATACAACAATTGTGGGTTTCAGCCTTGGTGGCTTAGCCGCTTTTTATGTAGCACTTCAAAATCCAC
ATATTTTCGGAAATGTGTTGTCAATGTCTGGATCCGTACATTGGAAAAAGGATGATTATGAAAATACAATTCCTTGGATT
GAAAATCAAATTTCATCAATAAATTCTAATGCGACTCATCTATATTCTTACATAACAGTAGGTGAACTTGAAAACGAATC
TCTTTTAACGGCTAATAGACGGCTATATAAAGCTTTAAAAGAAAAGAAATACCAAACCACTTATGAAGAGTTTCAAGGCG
GACATGATAGCGTGTGGTGGCGAGAAAAGCTATTCGATGGATTAAGGGCATTAGAACTTACAAAAACGACACTAAAAAAT
AAAAAGGAGAGAGAATCTATGAATCAAGAAGAACTAGATAAAAAACTAAAAAAGCAAGAGATTTTAGTAAAAGATGAGAA
AGTTTGGTCCTATACGTATGAGGATCATATTAGTTCTATCGTTAAAGAGGCAGAAAAGAAAGGGGCTTTCGATCATTTAC
CTGGTAAAGGGAAACCTCTTAATCTTGATAAAGACCTTTCGTACAATCCTGAAAAGCAACTGTATAGAACTTTGAAAAAT
AATCATGTTTTACCTAGGTGGATTGAGCTTTCAAAGGAAATTGATGACTTAAAAGAAAAACTAAAAGAAAATACAAATAC
TGCAGAAGCAGCGGATTTAATTCGAACTATTAATAAAAAGGTTTTAGAACATAACCTACTTTGTCCACCAAGCGCGCAAA
AAACGAGGGTGAAAACGGACTTTTAA

Upstream 100 bases:

>100_bases
CTAATCAATAACTTCTCTAAACACATAAATTACGACTACTTTTATATAGGGATTCTAATGAAAAAAACTACATATAGAAT
ACTACAAACGAGGAGGAGAG

Downstream 100 bases:

>100_bases
CAATTTTTAATAAAGCTATCTCTTGCTATATAATTAAGTAAGGCATTTTCAATTCATTATTAAAGGGAGGCAAATGTGAT
GAAAAATACGTATGAACTTC

Product: esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTTIISPTLEKLKNQLKNGNEKALYTFLDEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTDIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMEVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVERLE
ELTYNDKMNTFLTKELLPWIQTKYHVYQKAKHTTIVGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSINSNATHLYSYITVGELENESLLTANRRLYKALKEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKN
KKERESMNQEELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF

Sequences:

>Translated_541_residues
MTTIISPTLEKLKNQLKNGNEKALYTFLDEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQL
QRLLQTDIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMEVQYSSRFPSNHYP
SGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVERLE
ELTYNDKMNTFLTKELLPWIQTKYHVYQKAKHTTIVGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWI
ENQISSINSNATHLYSYITVGELENESLLTANRRLYKALKEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKN
KKERESMNQEELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF
>Mature_540_residues
TTIISPTLEKLKNQLKNGNEKALYTFLDEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQ
RLLQTDIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLKIDMEVQYSSRFPSNHYPS
GKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVERLEE
LTYNDKMNTFLTKELLPWIQTKYHVYQKAKHTTIVGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIE
NQISSINSNATHLYSYITVGELENESLLTANRRLYKALKEKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNK
KERESMNQEELDKKLKKQEILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKNN
HVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTDF

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=326, Percent_Identity=25.7668711656442, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 63292; Mature: 63161

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIISPTLEKLKNQLKNGNEKALYTFLDEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTDIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEHHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMEVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKL
CCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVERLE
EEECCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCEEHHHHCHHHHHH
ELTYNDKMNTFLTKELLPWIQTKYHVYQKAKHTTIVGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCEEHHH
SMSGSVHWKKDDYENTIPWIENQISSINSNATHLYSYITVGELENESLLTANRRLYKALK
CCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
EKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNKKERESMNQEELDKKLKKQE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHH
ILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
HEEECCHHEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
F
C
>Mature Secondary Structure 
TTIISPTLEKLKNQLKNGNEKALYTFLDEIKSNHTPLVEQCPIDNQYKLITYIWLGDQN
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCC
TENVYVVGSFPGWDLSVNQLQRLLQTDIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSE
CCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEEECCCEEEEEEEEEHHHHHHHHHHCCCC
QYRLDPFNENVFGEGANKASVLKIDMEVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKL
CCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEE
HIYTPHDYSHTSHLQELLIVFDGNSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVERLE
EEECCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHHHHEECCCCCCEEHHHHCHHHHHH
ELTYNDKMNTFLTKELLPWIQTKYHVYQKAKHTTIVGFSLGGLAAFYVALQNPHIFGNVL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCCCEEHHH
SMSGSVHWKKDDYENTIPWIENQISSINSNATHLYSYITVGELENESLLTANRRLYKALK
CCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
EKKYQTTYEEFQGGHDSVWWREKLFDGLRALELTKTTLKNKKERESMNQEELDKKLKKQE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHH
ILVKDEKVWSYTYEDHISSIVKEAEKKGAFDHLPGKGKPLNLDKDLSYNPEKQLYRTLKN
HEEECCHHEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
NHVLPRWIELSKEIDDLKEKLKENTNTAEAADLIRTINKKVLEHNLLCPPSAQKTRVKTD
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]