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The map label for this gene is yjjG [H]

Identifier: 52142783

GI number: 52142783

Start: 2590690

End: 2591385

Strand: Reverse

Name: yjjG [H]

Synonym: BCZK2458

Alternate gene names: 52142783

Gene position: 2591385-2590690 (Counterclockwise)

Preceding gene: 52142780

Following gene: 52142782

Centisome position: 48.89

GC content: 27.87

Gene sequence:

>696_bases
TTGATGAGTTATAAAGCTATGCTGTTTGATTTAGATGATACGTTACTTAATAGGGATATGGCAGTAAATACATTGTTTTT
ATTTGTTTTAGAAAAGTGTTATGAAGATGTTAGTGATACAGTTAAAAACAATATGCTACGGAAATTCAAAGAATATGATA
AAAGAGAATATGGCATGAGTGATAAAACGATAGTTTTAGAATCGTTGTTTGATGAATTTCCGCCGAAGTATAGATTGTCA
CGCAATTATATCCAAGATTTTTGGAATGAAAACTTCCCAAAATGTTTTTCACTTGATCAAAATACTATTCATTTCTTAAA
TCATATAAAGAAGTACTTTGAAATTGGAATTATAACAAATGGCTCAAGTCTGAGGCAAAGAGCTAAAATAATTAACACGA
ATTTAAACAATTACTTTGATACAATCATTATTTCTGAAGAAGTAGGATTTAGTAAACCAGATAAACGTATATTCGAACTA
GCATTAAATAAACTTGATGTGCAACCAGAAGATGTATTATTTATTGGAGATGACTTAGAAAAGGATATTGCTGGTCCTCA
AAATACAAATATAAAAGGGATATGGTTTAATCCTCATAGAATCATGAATAAAACTGAAATAAAACCATATTCTGAGATTG
ACACTTTTAATAGTTTATTAAGTTATGTTACTCCGCAATGTTTTTATAATAAGTAA

Upstream 100 bases:

>100_bases
AACTCTTAGAATATCGTTCTATTAGAAGTTCTTTGAGATGAATTGTTTTTTTGATTACTTTTGATTATAACTAGGAAATA
TAGGAAGGTTGTGAATTTAT

Downstream 100 bases:

>100_bases
AAATATTGCGGAGTAATGAATTTTTATATTCTAAATAAATAATTAAAAAAGATTTTATTTAGCGCTTTGTAAGTAAGAAC
AAAGAAACACTCATTACTGG

Product: HAD superfamily hydrolase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MMSYKAMLFDLDDTLLNRDMAVNTLFLFVLEKCYEDVSDTVKNNMLRKFKEYDKREYGMSDKTIVLESLFDEFPPKYRLS
RNYIQDFWNENFPKCFSLDQNTIHFLNHIKKYFEIGIITNGSSLRQRAKIINTNLNNYFDTIIISEEVGFSKPDKRIFEL
ALNKLDVQPEDVLFIGDDLEKDIAGPQNTNIKGIWFNPHRIMNKTEIKPYSEIDTFNSLLSYVTPQCFYNK

Sequences:

>Translated_231_residues
MMSYKAMLFDLDDTLLNRDMAVNTLFLFVLEKCYEDVSDTVKNNMLRKFKEYDKREYGMSDKTIVLESLFDEFPPKYRLS
RNYIQDFWNENFPKCFSLDQNTIHFLNHIKKYFEIGIITNGSSLRQRAKIINTNLNNYFDTIIISEEVGFSKPDKRIFEL
ALNKLDVQPEDVLFIGDDLEKDIAGPQNTNIKGIWFNPHRIMNKTEIKPYSEIDTFNSLLSYVTPQCFYNK
>Mature_231_residues
MMSYKAMLFDLDDTLLNRDMAVNTLFLFVLEKCYEDVSDTVKNNMLRKFKEYDKREYGMSDKTIVLESLFDEFPPKYRLS
RNYIQDFWNENFPKCFSLDQNTIHFLNHIKKYFEIGIITNGSSLRQRAKIINTNLNNYFDTIIISEEVGFSKPDKRIFEL
ALNKLDVQPEDVLFIGDDLEKDIAGPQNTNIKGIWFNPHRIMNKTEIKPYSEIDTFNSLLSYVTPQCFYNK

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=117, Percent_Identity=31.6239316239316, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790833, Length=225, Percent_Identity=28, Blast_Score=88, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28571108, Length=234, Percent_Identity=24.3589743589744, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552117, Length=117, Percent_Identity=29.0598290598291, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 27351; Mature: 27351

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSYKAMLFDLDDTLLNRDMAVNTLFLFVLEKCYEDVSDTVKNNMLRKFKEYDKREYGMS
CCCCHHHEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKTIVLESLFDEFPPKYRLSRNYIQDFWNENFPKCFSLDQNTIHFLNHIKKYFEIGIITN
CHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHEEEEC
GSSLRQRAKIINTNLNNYFDTIIISEEVGFSKPDKRIFELALNKLDVQPEDVLFIGDDLE
CHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHH
KDIAGPQNTNIKGIWFNPHRIMNKTEIKPYSEIDTFNSLLSYVTPQCFYNK
HHCCCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MMSYKAMLFDLDDTLLNRDMAVNTLFLFVLEKCYEDVSDTVKNNMLRKFKEYDKREYGMS
CCCCHHHEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKTIVLESLFDEFPPKYRLSRNYIQDFWNENFPKCFSLDQNTIHFLNHIKKYFEIGIITN
CHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHEEEEC
GSSLRQRAKIINTNLNNYFDTIIISEEVGFSKPDKRIFELALNKLDVQPEDVLFIGDDLE
CHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCHH
KDIAGPQNTNIKGIWFNPHRIMNKTEIKPYSEIDTFNSLLSYVTPQCFYNK
HHCCCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]