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The map label for this gene is glcR [H]

Identifier: 52142742

GI number: 52142742

Start: 2629683

End: 2630453

Strand: Reverse

Name: glcR [H]

Synonym: BCZK2498

Alternate gene names: 52142742

Gene position: 2630453-2629683 (Counterclockwise)

Preceding gene: 52142740

Following gene: 52142743

Centisome position: 49.62

GC content: 33.07

Gene sequence:

>771_bases
ATGTTTACTGAAGAGCGTAGAGAGAAAATTTTAGAGTTACTTAAGAAAAATGGAAGGGTAATTGCAAAGGATCTTGCGGA
AAGTTTCGATATGTCTATCGATTCTATAAGAAGAGATTTGTCTATTATGGAGAAGGATGGCTTGTTAAAAAGAACACATG
GAGGAGCAATTGAACTTGCTAGAGTAAGGAATTTAGCTGCCAAGCCATTGAAACGTTATAGTAATGGTTCTGTATATGAA
GATGCAATTGCAAAAATCGCAGCTTCTTATATACAAGAGGGAGATTCCGTTTTTATTGGTGGAGCTTCTATTCATTATGC
CATGTTAAAATATTTACCTGAAACATCATTTACAGTTATTACGAATGCTTTAGAAATTGCTAGTACGTTACGGGAATATA
AGAACATTGATATGTACTTAATTGGTGGAATGGTGAAACCATCAGGAAATATGACAGATACACTTGCCTCAGAGTTGATA
AGTAGATTTTCTATTGATCTTAATTTCTCTACAGGTGATGGCATTTCATTAAACGGTATAAGTACTGCAACGCCGGAAAT
TGCTTTTTTTAGTAAATCAGTAAGTAAGATTGCTAGAAGAAATATTTGTTTAGCTCTTCATAATAAACTTGGAATAGACT
ACTTTATAAAAGGAGAGTCACTGATTGAAATTGACCTTATAATAACAGATTCGGAGGCTAGTAAAGAAACAATTCAAGAA
TTTGAGAAACAAGGTAAAGAAATTGTAATAGCACCAATAGACTGCATTTAA

Upstream 100 bases:

>100_bases
CGGAGTGAATAAGAATTGAAAATATTGTAAAGCGGAAGAGACATGCATATAATTAAAATAAGGATAAGATTTCAGAATCT
TCAATAATGGCGGTGGACAC

Downstream 100 bases:

>100_bases
AAGGAGTTTGTAATGATTATAAAAGGGCAAGAGTTTCACATAAATGGATTAACTTATACAATTCGTTCTGCAGCTGAAAC
AGATGCGGAACAGTTATCGG

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELARVRNLAAKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVITNALEIASTLREYKNIDMYLIGGMVKPSGNMTDTLASELI
SRFSIDLNFSTGDGISLNGISTATPEIAFFSKSVSKIARRNICLALHNKLGIDYFIKGESLIEIDLIITDSEASKETIQE
FEKQGKEIVIAPIDCI

Sequences:

>Translated_256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELARVRNLAAKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVITNALEIASTLREYKNIDMYLIGGMVKPSGNMTDTLASELI
SRFSIDLNFSTGDGISLNGISTATPEIAFFSKSVSKIARRNICLALHNKLGIDYFIKGESLIEIDLIITDSEASKETIQE
FEKQGKEIVIAPIDCI
>Mature_256_residues
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELARVRNLAAKPLKRYSNGSVYE
DAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVITNALEIASTLREYKNIDMYLIGGMVKPSGNMTDTLASELI
SRFSIDLNFSTGDGISLNGISTATPEIAFFSKSVSKIARRNICLALHNKLGIDYFIKGESLIEIDLIITDSEASKETIQE
FEKQGKEIVIAPIDCI

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=254, Percent_Identity=30.7086614173228, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=24.901185770751, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI226510968, Length=253, Percent_Identity=26.4822134387352, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790635, Length=250, Percent_Identity=24.4, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789829, Length=247, Percent_Identity=24.2914979757085, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790753, Length=252, Percent_Identity=25.7936507936508, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082344, Length=142, Percent_Identity=28.8732394366197, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788069, Length=243, Percent_Identity=26.3374485596708, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787540, Length=191, Percent_Identity=29.8429319371728, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789170, Length=177, Percent_Identity=27.1186440677966, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28356; Mature: 28356

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELA
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEHHH
RVRNLAAKPLKRYSNGSVYEDAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCHHHH
TNALEIASTLREYKNIDMYLIGGMVKPSGNMTDTLASELISRFSIDLNFSTGDGISLNGI
HHHHHHHHHHHHHHCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEECCCCCEEECCC
STATPEIAFFSKSVSKIARRNICLALHNKLGIDYFIKGESLIEIDLIITDSEASKETIQE
CCCCCHHHHHHHHHHHHHHHHHHEEEHHHCCCEEEECCCCEEEEEEEEECCCCCHHHHHH
FEKQGKEIVIAPIDCI
HHHCCCEEEEEECCCC
>Mature Secondary Structure
MFTEERREKILELLKKNGRVIAKDLAESFDMSIDSIRRDLSIMEKDGLLKRTHGGAIELA
CCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCEEHHH
RVRNLAAKPLKRYSNGSVYEDAIAKIAASYIQEGDSVFIGGASIHYAMLKYLPETSFTVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCHHHH
TNALEIASTLREYKNIDMYLIGGMVKPSGNMTDTLASELISRFSIDLNFSTGDGISLNGI
HHHHHHHHHHHHHHCCCEEEECCEECCCCCCHHHHHHHHHHHHEEEEEECCCCCEEECCC
STATPEIAFFSKSVSKIARRNICLALHNKLGIDYFIKGESLIEIDLIITDSEASKETIQE
CCCCCHHHHHHHHHHHHHHHHHHEEEHHHCCCEEEECCCCEEEEEEEEECCCCCHHHHHH
FEKQGKEIVIAPIDCI
HHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]