Click here to switch to the map view.

The map label for this gene is iunH [H]

Identifier: 52142625

GI number: 52142625

Start: 2734539

End: 2735504

Strand: Reverse

Name: iunH [H]

Synonym: BCZK2619

Alternate gene names: 52142625

Gene position: 2735504-2734539 (Counterclockwise)

Preceding gene: 52142620

Following gene: 52142624

Centisome position: 51.6

GC content: 34.27

Gene sequence:

>966_bases
GTGAGTATAGTTAATAAGAAAATCATCTTTTTTGGAGACTTTGGTATTGATGATGCTGTGGCGTTAATTTATGCAAATAA
AACATGTAAATTAGATATTTTAGGTATTGTTGCTGAATATGGGAATGTATCGAGAGAAATCGTAACAGAAAATGTGTATT
TTTTAGAAAGATACTATGCTACAAAAGTAAAAATCATTGAGGGTGCAGCAAGACCGATGACAGCTGAAGAACCTTTGTTT
TTTCCTGAAATTCATGGAGAGCACGGCCTAGGTCCCATTATTCCACCTGAAATGAGGATTTGTAAACGGGAAAATTTTTG
TGAATTAATTAAATTAATTGAGCCTTGTCCAGAAGATATTATTATCGTAGCGACAGGACGATTAACAACATTGGCAACAT
TATTTTTATTATATCCAAATGTCATGGATAAAGTATGTTCGTATTATATTATGGGCGGTGCGTTTTTATTTCCTGGTAAT
GTTACTCCTGTATCAGAAGCGAATTTTTATGGAGATCCAATTGCTGCAAATATTGTAATGAAGTACGCAAAGAATGCGAC
TATTTATCCATTAAATGTAACGCAACAGGCCCTAATTACGCCTGAAATGGTGGATATTATTAATAAAGAAGGAACAGGGC
AGGCAAAGCTTATTAAACCAATGATTGATTTTTATTATGAGAACTTTTATAAAAAAGAATACCCGGGTATTGCTGGAAGT
CCGATTCACGATTTGCTTCCGTTCATTTCATTTATAAATGATGATATTTTTGAATATAAAAAATCTGCAGTTTGGATTAG
TACGACAAATGACGTAACAAGAGGACAAAGTGTGGCTGACTTTAGAAAAATAGCTGAGCCGACGAGGTTTGATGATCGGC
CGATACAAAGAATTGCGGTTGGTTTTAATTATCCTGCATTTAAAGAAGAGTTTATGCGGACAATATTGAAGCCCGATTGT
CCATAA

Upstream 100 bases:

>100_bases
AGATTGAAGTCGCCAATAAATAGGCGGCTTTTTTAGTTTGCACCGTTTCACAGCCTTGTCTTTTTTACATACTAATAATA
GTAGATAATGCTGAAGAGGG

Downstream 100 bases:

>100_bases
TAAGTGTAATATCTCAAGCTGCATAAATCGTTAGTCAAAAAAGTTAATTAACATGTATTATTTTTACAAAAAAATACAGT
TATGCTCCATGAATAACTTA

Product: inosine-uridine preferring nucleoside hydrolase

Products: D-ribose; purine

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSIVNKKIIFFGDFGIDDAVALIYANKTCKLDILGIVAEYGNVSREIVTENVYFLERYYATKVKIIEGAARPMTAEEPLF
FPEIHGEHGLGPIIPPEMRICKRENFCELIKLIEPCPEDIIIVATGRLTTLATLFLLYPNVMDKVCSYYIMGGAFLFPGN
VTPVSEANFYGDPIAANIVMKYAKNATIYPLNVTQQALITPEMVDIINKEGTGQAKLIKPMIDFYYENFYKKEYPGIAGS
PIHDLLPFISFINDDIFEYKKSAVWISTTNDVTRGQSVADFRKIAEPTRFDDRPIQRIAVGFNYPAFKEEFMRTILKPDC
P

Sequences:

>Translated_321_residues
MSIVNKKIIFFGDFGIDDAVALIYANKTCKLDILGIVAEYGNVSREIVTENVYFLERYYATKVKIIEGAARPMTAEEPLF
FPEIHGEHGLGPIIPPEMRICKRENFCELIKLIEPCPEDIIIVATGRLTTLATLFLLYPNVMDKVCSYYIMGGAFLFPGN
VTPVSEANFYGDPIAANIVMKYAKNATIYPLNVTQQALITPEMVDIINKEGTGQAKLIKPMIDFYYENFYKKEYPGIAGS
PIHDLLPFISFINDDIFEYKKSAVWISTTNDVTRGQSVADFRKIAEPTRFDDRPIQRIAVGFNYPAFKEEFMRTILKPDC
P
>Mature_320_residues
SIVNKKIIFFGDFGIDDAVALIYANKTCKLDILGIVAEYGNVSREIVTENVYFLERYYATKVKIIEGAARPMTAEEPLFF
PEIHGEHGLGPIIPPEMRICKRENFCELIKLIEPCPEDIIIVATGRLTTLATLFLLYPNVMDKVCSYYIMGGAFLFPGNV
TPVSEANFYGDPIAANIVMKYAKNATIYPLNVTQQALITPEMVDIINKEGTGQAKLIKPMIDFYYENFYKKEYPGIAGSP
IHDLLPFISFINDDIFEYKKSAVWISTTNDVTRGQSVADFRKIAEPTRFDDRPIQRIAVGFNYPAFKEEFMRTILKPDCP

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=277, Percent_Identity=30.6859205776173, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788486, Length=277, Percent_Identity=27.7978339350181, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786213, Length=274, Percent_Identity=28.4671532846715, Blast_Score=85, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320608, Length=293, Percent_Identity=30.3754266211604, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: 3.2.2.1

Molecular weight: Translated: 36313; Mature: 36181

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVNKKIIFFGDFGIDDAVALIYANKTCKLDILGIVAEYGNVSREIVTENVYFLERYYA
CCCCCCEEEEEECCCCCCEEEEEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TKVKIIEGAARPMTAEEPLFFPEIHGEHGLGPIIPPEMRICKRENFCELIKLIEPCPEDI
HHEEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCE
IIVATGRLTTLATLFLLYPNVMDKVCSYYIMGGAFLFPGNVTPVSEANFYGDPIAANIVM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHH
KYAKNATIYPLNVTQQALITPEMVDIINKEGTGQAKLIKPMIDFYYENFYKKEYPGIAGS
HHHCCCEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIHDLLPFISFINDDIFEYKKSAVWISTTNDVTRGQSVADFRKIAEPTRFDDRPIQRIAV
CHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHEEE
GFNYPAFKEEFMRTILKPDCP
CCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIVNKKIIFFGDFGIDDAVALIYANKTCKLDILGIVAEYGNVSREIVTENVYFLERYYA
CCCCCEEEEEECCCCCCEEEEEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TKVKIIEGAARPMTAEEPLFFPEIHGEHGLGPIIPPEMRICKRENFCELIKLIEPCPEDI
HHEEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCE
IIVATGRLTTLATLFLLYPNVMDKVCSYYIMGGAFLFPGNVTPVSEANFYGDPIAANIVM
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHH
KYAKNATIYPLNVTQQALITPEMVDIINKEGTGQAKLIKPMIDFYYENFYKKEYPGIAGS
HHHCCCEEEEECCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIHDLLPFISFINDDIFEYKKSAVWISTTNDVTRGQSVADFRKIAEPTRFDDRPIQRIAV
CHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHEEE
GFNYPAFKEEFMRTILKPDCP
CCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-D-ribosylpurine; H2O

Specific reaction: an N-D-ribosylpurine + H2O = D-ribose + a purine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA