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The map label for this gene is hisC [H]

Identifier: 52142567

GI number: 52142567

Start: 2788753

End: 2789853

Strand: Reverse

Name: hisC [H]

Synonym: BCZK2675

Alternate gene names: 52142567

Gene position: 2789853-2788753 (Counterclockwise)

Preceding gene: 52142566

Following gene: 52142568

Centisome position: 52.63

GC content: 37.42

Gene sequence:

>1101_bases
ATGCAAGTAAAAGATCAACTATCATTATTACAACCATATAAACCAGGTAAATCACCTGAACAAATGAAAGAAGTGTACGG
AGATCATTCGTTTGTTAAATTAGCATCGAATGAAAATTCATTCGGCTGTTCGCCACGAGTTTTAGATGAGTTGCAAAAAT
CGTGGTTGGATCATGCTTTATATCCTGACGGAGGTGCTACAACACTCCGTCAAACAATTGCAAATAAGTTACATGTGCAA
ATGGAACAAGTACTTTGCGGTAGTGGTTTAGATGAAGTCATTCAAATAATAAGCCGTGCAGTACTTAAAGCAGGAGATAA
CATCGTAACGGCTGGGGCAACATTCCCGCAGTACCGTCATCATGCAATTATAGAAGGTTGCGAAGTGAAGGAAGTTGCGT
TAAATAACGGTGTATACGACTTAGACGAAATTTCTTCAGTAGTAGATAACAATACAAAAATCGTATGGATTTGTAACCCG
AACAATCCAACAGGCACATATGTGAATGACCGAAAATTGACTCAATTCATTGAAGGGATTAGTGAAAATACGTTAATTGT
CATTGATGAAGCGTACTATGAATACGTAACAGCAAAAGATTTCCCAGAGACATTACCGCTTTTAGAAAAACATAAAAATA
TTCTTGTGCTTAGAACATTTTCTAAAGCGTACGGATTAGCTTCTTTCCGCGTTGGATATGCGGTTGGACATGAAGAATTA
ATCGAAAAATTAAATGTTGTTCGTTTGCCATTTAACGTATCTTCATTAGCGCAAAAAGCAGCGACGATTGCTTTTGGTGA
TGACGAGTTTATTGAAGAAATAGTTCGTGTGAATACAGAAGGTTTACGACAATACGAAAGTTTCTGTAAGGAAAATGAAA
TTCCATTTTATCAGTCACAAACAAATTTCATCTTCTTGCCAGTAGAAAATGGTGGAGAGATTTATGAAGCTTGCGCACAC
GCAGGGTTTATTATTCGTCCGTTCCCGAATGGTGTCCGCATCACAGTCGGAACAAGGGAGCAAAATGAAGGAGTGATTTC
AGTGTTACAACAACACTTTGAAAATAAAAAAAGAAAGTCTCGAGATGAGGCAAATGTGTAA

Upstream 100 bases:

>100_bases
AGTCGAACAATTCGGAAAAGATCGTATGGAATTAATTCAACAAAACATTACGCAACATAATAAATACGCAAAAGAATTTT
AATAAAAAGGTGGTTTTAAC

Downstream 100 bases:

>100_bases
AAAGGTAGTATTAATTGGAACGGGTTTAATCGGAGGCTCTCTCGCATTAGCGATTAAGAAGGAGCACGATGTAACGATAA
CAGGTTATGATATATTTCAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MQVKDQLSLLQPYKPGKSPEQMKEVYGDHSFVKLASNENSFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVQ
MEQVLCGSGLDEVIQIISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNNTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANV

Sequences:

>Translated_366_residues
MQVKDQLSLLQPYKPGKSPEQMKEVYGDHSFVKLASNENSFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVQ
MEQVLCGSGLDEVIQIISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNNTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANV
>Mature_366_residues
MQVKDQLSLLQPYKPGKSPEQMKEVYGDHSFVKLASNENSFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVQ
MEQVLCGSGLDEVIQIISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNNTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=305, Percent_Identity=30.8196721311475, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788627, Length=234, Percent_Identity=27.3504273504274, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=363, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41137; Mature: 41137

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKDQLSLLQPYKPGKSPEQMKEVYGDHSFVKLASNENSFGCSPRVLDELQKSWLDHAL
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVQMEQVLCGSGLDEVIQIISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNNTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANV
CCCCCC
>Mature Secondary Structure
MQVKDQLSLLQPYKPGKSPEQMKEVYGDHSFVKLASNENSFGCSPRVLDELQKSWLDHAL
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVQMEQVLCGSGLDEVIQIISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNNTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCCHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]