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The map label for this gene is menA [H]

Identifier: 52142358

GI number: 52142358

Start: 3013698

End: 3014609

Strand: Reverse

Name: menA [H]

Synonym: BCZK2885

Alternate gene names: 52142358

Gene position: 3014609-3013698 (Counterclockwise)

Preceding gene: 52142356

Following gene: 52142360

Centisome position: 56.87

GC content: 37.72

Gene sequence:

>912_bases
ATGGGGACAGAAAAAGAAATTAGTTCCGCTAAATTAATATGGAAGATGACGCGCCCGCATACGTTAACGGCGACGTTTTC
TCCTGTAATTTTAGGAACAGTGGCATCACTTTATGTTGCCAAAATTGATTGGCTTTTATTTATTGCGATGATGTGCGCAT
GTTTAGCATTGCAAATAGCAACGAACTTATTTAATGAGTACTATGATTTCAAACGTGGATTAGATACCGCTGATTCTGTT
GGAATTGGTGGCGGAATTGTTCGTCATGGATTGAAACCAAAAAATGTTTTAACAGTTGCGCTTTTATTGTACGTAGTAGC
AGCAATTATTGGAGTTTATATTTGTATGAATAGCAGCTGGTGGTTAGTTGTCATCGGTTTAATTGGGATGGCGGTTGGCT
ATTTATATACAGGTGGTCCATTACCAATTGCGTACACTCCGTTTGGAGAATTAGTTTCTGGATTGTTAATGGGGACATGT
TTTGTACTCATCGCTTTCTTTATTCAAACGAATACGATAACGACTGAAAGTGTATTAATTTCCATTCCAATTGGAATTTT
AGTCGGTGCAATCAACATGTCAAATAACATCCGAGATATCGAAGAAGATATTAAAGGTGGAAGAAAGACGTTGGTAATCC
TCCTTGGGAGAGAAAAAGCAATAGTAACACTAGCTGTAGCCTTTTTCATTGCTTATTTATGGATCGCCGTAATTGTATTA
ATGGGTTATATAAGCCCCTGGGCATTAGTTATGTTCCTAGGTTTGAGAAAGCCAATCTCTGCCATTCAAAGTTTCCAAAA
AGGGGCAAAAGATTCCGGGTATATGCGCATCGCCATGAAATCAACAGCGATGACAAATACGATTTTTGGCTTCTTATTAT
CGGCAGGATTATTAATCAGTTACTTGTTTTAA

Upstream 100 bases:

>100_bases
CACCAATTCATTTTTTGATATAATAGATGCGTGGCAGGAAATAGATAGAAAGATACTGCTAGCAATTTATACTTAAAATG
TTGGGAGATTGAACAGAGTT

Downstream 100 bases:

>100_bases
ATAAAAAATATTATTACGTGACTAAACCCCAATTTCTCAATTTTAATATAGAGAAATTGGGGTTTTATTTTTATAGCGTG
TATTTTCCCTTTTAATCAAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMCACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTC
FVLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAIVTLAVAFFIAYLWIAVIVL
MGYISPWALVMFLGLRKPISAIQSFQKGAKDSGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Sequences:

>Translated_303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMCACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTC
FVLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAIVTLAVAFFIAYLWIAVIVL
MGYISPWALVMFLGLRKPISAIQSFQKGAKDSGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF
>Mature_302_residues
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMCACLALQIATNLFNEYYDFKRGLDTADSVG
IGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCF
VLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAIVTLAVAFFIAYLWIAVIVLM
GYISPWALVMFLGLRKPISAIQSFQKGAKDSGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=290, Percent_Identity=27.2413793103448, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790365, Length=224, Percent_Identity=27.6785714285714, Blast_Score=85, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737429, Length=290, Percent_Identity=27.5862068965517, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32964; Mature: 32833

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMCACLALQIA
CCCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCFVLIAFFIQTNTITTESVLI
HHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHE
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAIVTLAVAFFIAYLWIAVIVL
EECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDSGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC
>Mature Secondary Structure 
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMCACLALQIA
CCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCFVLIAFFIQTNTITTESVLI
HHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHE
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAIVTLAVAFFIAYLWIAVIVL
EECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDSGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]