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The map label for this gene is pbp [H]

Identifier: 52142326

GI number: 52142326

Start: 3044469

End: 3046544

Strand: Reverse

Name: pbp [H]

Synonym: BCZK2916

Alternate gene names: 52142326

Gene position: 3046544-3044469 (Counterclockwise)

Preceding gene: 52142325

Following gene: 52142329

Centisome position: 57.47

GC content: 41.52

Gene sequence:

>2076_bases
ATGGAAAATAAATTATCTGGAGTGTTAGCCGCTACCTTAGCTCTAACGATGAGCCTACCAACAGGAGCGATAGCGTCTTC
TAGCAGTAAGACTCCGGTTGTATCTAGCCAAGAAGTTGCTAGCAAAGATTTGGAGAAGATTGCTGCAGAGAACGCTGCAC
TGCTCACGAAGTCCTATGAGACGACTAGTGTACAGTATGCGCTGATTGATAATGGTAAACTTATTTTGTCAGGACAGACA
GGCAAGAATGACATAGAGGGGAAAGAGCCATTAACCAAAGATACTCTATACGGAATTGGTTCAACCAGTAAAGTATATAC
AGCTGCGGCTGTTATGAAATTAGTAGACGAAGGACAAGTTGATTTGGATGCTTCTGTTACCCGCTATATTCCTGAGTTCA
AAATGAAAGATGAACGATATAAACGCATTACACCGCGTATGCTGTTGAATCACTCCTCAGGTTTGCAAGGTTCGACGCTT
AATAATGCATTTTTATTTAAAGATAATGATGTTTATGCCCATGATATCTTGTTGCAACAATTGTCCAACCAAAACTTGAA
GGCAGACCCTGGCGCGTTCTCAGTATACTGTAATGACGGTTTTACGCTGGCTGAGATCTTGGTAGAAAGAGTCAGCGGTA
TGAGTTTTACTGAATTTCTACATCAAAAGTTTACAGAGCCATTAAAACTGAATCATACGATAACATCGCAAGATAAATGG
GAAGATGAAAAGCGGGCTGGACAGTATTCTCCGACATACCAGGGACAGCTTCCAAGTGAAATGGTAAATGTGATTGGTAC
GGGAGGAATCTCTTCTACTGCAGAAGATGTGGTGCGATTCTCACAAATATTTATGGGACAGGGAAAAGAAATCCTCTCTA
ATAAAGCAGTCAAGACGATGGAACAAGAAGAATATAAAAAAGGAATGTGGCCGGGAGATAGCGGAAATGTGTTCAACTAT
GGTCTTGGCTGGGATAGTGTGAAACTATACCCATTCAGTGAATATGGGATAAAAGCGTTGACTAAGGGTGGGGATACGAT
GCTGCAACATGCTACATTGGTCGTACTTCCAGAACAGAAGATGGCAGCAGCTGTATTGTCCTCCGGCGGCTCCAGCATGA
CAAATCAACTGTTGGCAAATAAATTACTGCTAGCTAGGCTTAAAGAGAAAGGGACAATTAAGGATATAAAACCAGATAAA
TCCTTCGGCAAGCCCGTCAAGGCTAAAGTGCCTCAAGACGTGGTAAAAAAAGCAGGATTTTATGGAAATAGCTATAGCCA
TTTCAAAATAGAAATTACGAAGAAGGGAGAACTGTTTTTACCAACTAAACCAGAAGAAAAATATGTATATACGGCGGATG
GAAGCTTTATAAATGAGAAGGGCACTTCCAAGCTTAACTTCGTCACAGAGAAGAATGGAAAAGTTTATTTGAGAGAGAGC
GCATATGAATTATCGCCGGGATTGGGGCAAAATGTGCTGACTCACTATTTAGCCCAGAAATTAGAAAACAATGTGTTACC
GAAGAAAACAGGTGCTGCATGGGCGAAGCGCGAGGGCGGCAAGTTCTACCTCGTTAACGAAAAATTTAATTCTATAAATT
ATTTAGGACAACAAATACCTCTTAACACACAAATTACGCTCAAAGATGGCTATTGGGACGGCAAAAAAATTACAGGTCCG
AATACGGCGACGCATCAAATTCAAATTCCCGTGATGAATGGGCGGGATACAAAGGAAGCCCATTTCTATACAGAGGATGG
TACTGAATATATGGAGATGTCCAGCTTTTTATACGTCAGTGAATCTAACGTAAAATCCCTTGATACAGGTCACTTATCGA
AAGTTACATTGCAAAAAAGTGGGCATGCGAAATGGTTTACGATCCCGCAAGAGGCAGCAGGGAAAATGATGAATGTGGAG
TTGCCATCAGGAAGTTCATTCGCGGTGTATGATGAGAATGGAGTATGCGTCAATTTTACCGTCGTTAGTGACAATAACAA
AGTGAAACTACCAGAGAACGGAACGGTTGTATTTGCTGGCGCACCGAACTCAGAATTTACAGTCGCATTGAACTAG

Upstream 100 bases:

>100_bases
ACGACAGTAGAGATAAAGCCAGAATAGTAGTTTATGTGATGTTTGTAATTGAGTAAATAAAAGATGAAACCGATCATTTA
TCTAAGGAGGAATTTTTCTT

Downstream 100 bases:

>100_bases
TTACAACTCGAGGTAGACTTTAATAAAACAGTATCACTTGGAAAAGATATTTTATTTGTATCTTAAGTATTCCCTTAAAT
GATATTACACTTAAATTCTT

Product: penicillin-binding protein

Products: substituted beta-amino acid

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGQVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKTMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTGAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGHLSKVTLQKSGHAKWFTIPQEAAGKMMNVE
LPSGSSFAVYDENGVCVNFTVVSDNNKVKLPENGTVVFAGAPNSEFTVALN

Sequences:

>Translated_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGQVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKTMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTGAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGHLSKVTLQKSGHAKWFTIPQEAAGKMMNVE
LPSGSSFAVYDENGVCVNFTVVSDNNKVKLPENGTVVFAGAPNSEFTVALN
>Mature_691_residues
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYETTSVQYALIDNGKLILSGQT
GKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGQVDLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTL
NNAFLFKDNDVYAHDILLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKTMEQEEYKKGMWPGDSGNVFNY
GLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQKMAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDK
SFGKPVKAKVPQDVVKKAGFYGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
AYELSPGLGQNVLTHYLAQKLENNVLPKKTGAAWAKREGGKFYLVNEKFNSINYLGQQIPLNTQITLKDGYWDGKKITGP
NTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVSESNVKSLDTGHLSKVTLQKSGHAKWFTIPQEAAGKMMNVE
LPSGSSFAVYDENGVCVNFTVVSDNNKVKLPENGTVVFAGAPNSEFTVALN

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=252, Percent_Identity=28.1746031746032, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786574, Length=315, Percent_Identity=24.7619047619048, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=280, Percent_Identity=27.5, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17550934, Length=298, Percent_Identity=27.1812080536913, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6

Molecular weight: Translated: 75936; Mature: 75936

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGQV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTLNNAFLFKDNDVYAHDILLQQ
CCCCHHHHHCCCCCCCCHHHHHCCHHHEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKTM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCCHHHHCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDKSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCC
YGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEECC
AYELSPGLGQNVLTHYLAQKLENNVLPKKTGAAWAKREGGKFYLVNEKFNSINYLGQQIP
CEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEECCCCCCHHHHHCCCC
LNTQITLKDGYWDGKKITGPNTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVS
CCEEEEEECCCCCCCEECCCCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHCEEEEEE
ESNVKSLDTGHLSKVTLQKSGHAKWFTIPQEAAGKMMNVELPSGSSFAVYDENGVCVNFT
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSDNNKVKLPENGTVVFAGAPNSEFTVALN
EECCCCEEECCCCCEEEEEECCCCCEEEEEC
>Mature Secondary Structure
MENKLSGVLAATLALTMSLPTGAIASSSSKTPVVSSQEVASKDLEKIAAENAALLTKSYE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCC
TTSVQYALIDNGKLILSGQTGKNDIEGKEPLTKDTLYGIGSTSKVYTAAAVMKLVDEGQV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHCCCC
DLDASVTRYIPEFKMKDERYKRITPRMLLNHSSGLQGSTLNNAFLFKDNDVYAHDILLQQ
CCCCHHHHHCCCCCCCCHHHHHCCHHHEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSGMSFTEFLHQKFTEPLKLNHTITSQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCEECCCCCC
EDEKRAGQYSPTYQGQLPSEMVNVIGTGGISSTAEDVVRFSQIFMGQGKEILSNKAVKTM
CHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EQEEYKKGMWPGDSGNVFNYGLGWDSVKLYPFSEYGIKALTKGGDTMLQHATLVVLPEQK
HHHHHHCCCCCCCCCCEEEECCCCCCEEEEECHHCCCCEECCCCCHHHHCEEEEEECCHH
MAAAVLSSGGSSMTNQLLANKLLLARLKEKGTIKDIKPDKSFGKPVKAKVPQDVVKKAGF
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCHHHHHHCCC
YGNSYSHFKIEITKKGELFLPTKPEEKYVYTADGSFINEKGTSKLNFVTEKNGKVYLRES
CCCCCCEEEEEEEECCCEECCCCCCCCEEEECCCCEECCCCCCEEEEEEECCCEEEEECC
AYELSPGLGQNVLTHYLAQKLENNVLPKKTGAAWAKREGGKFYLVNEKFNSINYLGQQIP
CEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEECCCCCCHHHHHCCCC
LNTQITLKDGYWDGKKITGPNTATHQIQIPVMNGRDTKEAHFYTEDGTEYMEMSSFLYVS
CCEEEEEECCCCCCCEECCCCCCEEEEEEEEECCCCCCCCEEEECCCHHHHHHCEEEEEE
ESNVKSLDTGHLSKVTLQKSGHAKWFTIPQEAAGKMMNVELPSGSSFAVYDENGVCVNFT
CCCCCCCCCCCCEEEEEECCCCEEEEECCHHHCCCEEEEECCCCCEEEEECCCCEEEEEE
VVSDNNKVKLPENGTVVFAGAPNSEFTVALN
EECCCCEEECCCCCEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: beta-lactam; H2O

Specific reaction: A beta-lactam + H2O = a substituted beta-amino acid

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]