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The map label for this gene is dxr [H]

Identifier: 52142188

GI number: 52142188

Start: 3184003

End: 3185160

Strand: Direct

Name: dxr [H]

Synonym: BCZK3054

Alternate gene names: 52142188

Gene position: 3184003-3185160 (Clockwise)

Preceding gene: 52142198

Following gene: 52142186

Centisome position: 60.07

GC content: 35.84

Gene sequence:

>1158_bases
ATGGTAAAATATATATCCATTTTAGGTTCAACAGGATCCATTGGCACATCTGCATTAGATGTCGTTTCAGCTCATCCTGA
ACATTTCAAAATCGTCGGTTTAACCGCAAATTATAATATCGAGCTTCTTGAACAACAAATCAAAATGTTCCAACCTCGCA
TTGTAAGCGTTGCGACAAAAGACTTAGCAGACACGCTTCGTATGCATATTTCAGCAAATACAAAAATCACATACGGAACT
GATGGCTTAATTGCGGTAGCTACTCACCCTGATTCAAATCTTGTATTAAGTTCCGTCGTTGGTGTTTCAGGATTACTCCC
AACAATTGAAGCATTAAAAGCGAAGAAAGATATTGCCATCGCTAATAAAGAAACGTTAGTTGCAGCTGGTCATATTGTAA
CTGAACTGGCCAAACAAAACGGATGTCGTTTAATTCCAGTCGATAGCGAACATTCAGCTATTTTCCAATGTTTAAACGGA
GAAAATAATAAAGAAATTGACAAATTAATCGTTACAGCTTCTGGCGGTGCATTCCGTGATAAAACACGTGAAGAAATGAA
AACTCTACAAGCAAAAGATGCTTTAAAGCACCCAAACTGGTTAATGGGGGCAAAACTAACGATTGATTCTGCCACATTAA
TGAATAAAGGGTTCGAAGTAATGGAAGCGAGATGGCTATTTGATATTCCGTATGAAAAAATTAATGTAATGATTCATAAA
GAAAGTATCATTCATTCTTTAGTAGAATTTATTGATGGATCAGTTATGGCACAGCTCGGTGCTCCTGATATGAGAATGCC
GATTCAATATGCGTTTCACTATCCTACTCGGCTACCTTCTTCCTATGAAAAATTAAATTTATTAGAAATCGGTAGTTTAC
ATTTTGAAAAACCAGATTTAGAGAAGTTTCCTTGTCTACAATACGCATATGAATGTGGCAAAATTGGCGGTACTACTCCT
GCTGTATTAAACGCAGCAAATGAAATTGCGAATGCACTATTCTTAAAAAATGAAATTGCCTTTTTCGATATTGAAAAAAC
AATTTACAAAACAGTTGAAGCCCATCATAACGTAAAAGATCCTTCACTAGATGCTATATTAGAAGCGGATCAATGGGCAC
GCCAATATGCAAATCAATTGTTAATAAAAAAGAGCTAA

Upstream 100 bases:

>100_bases
AACCAAAATTTTCTATTTTATATAGAAGGAATTTCCACTTCAATTGTCTAATATTATATAGGTTTGCAGAAATACTCGAA
ACAACTTTGGAGGTTTTTTC

Downstream 100 bases:

>100_bases
AACAGATAATACTGTTTTAGCTCTTTTTCCTACGTATTCAACTTAACAAATCGATAACCATGCGTAACTAACACTTTTAA
TATCGCATATCCTGGAATTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 1; 1-deoxyxylulose-5-phosphate reductoisomerase 1; 2-C-methyl-D-erythritol 4-phosphate synthase 1 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKMFQPRIVSVATKDLADTLRMHISANTKITYGT
DGLIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Sequences:

>Translated_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKMFQPRIVSVATKDLADTLRMHISANTKITYGT
DGLIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS
>Mature_385_residues
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKMFQPRIVSVATKDLADTLRMHISANTKITYGT
DGLIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNG
ENNKEIDKLIVTASGGAFRDKTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
ESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTP
AVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANQLLIKKS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=39.3939393939394, Blast_Score=293, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42562; Mature: 42562

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKMFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
DLADTLRMHISANTKITYGTDGLIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHEEECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCHHEECCCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGTTPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIELLEQQIKMFQPRIVSVATK
CEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
DLADTLRMHISANTKITYGTDGLIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAI
HHHHHHHHEEECCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
ANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLNGENNKEIDKLIVTASGGAFRD
CCCCCEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCHH
KTREEMKTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYEKINVMIHK
HHHHHHHHHHHHHHHCCCCEEECCEEEECHHHHHHCCHHHHHEEEEEECCHHHEEEEEEH
ESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDL
HHHHHHHHHHHCCHHEECCCCCCCCCCEEEEEECCCCCCCCHHHCCEEEECCCCCCCCCC
EKFPCLQYAYECGKIGGTTPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKD
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCC
PSLDAILEADQWARQYANQLLIKKS
CCHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]