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The map label for this gene is yrkA [H]

Identifier: 52142176

GI number: 52142176

Start: 3193582

End: 3194910

Strand: Reverse

Name: yrkA [H]

Synonym: BCZK3066

Alternate gene names: 52142176

Gene position: 3194910-3193582 (Counterclockwise)

Preceding gene: 52142175

Following gene: 52142177

Centisome position: 60.27

GC content: 36.57

Gene sequence:

>1329_bases
TTGGAAATATTTAATTTAGTCATGGTTGCGATTTTAATCGCATTTACTGGATTTTTCGTAGCAGCTGAGTTTGCGATTGT
AAAAGTACGTTCAAGTCGTATTGATCAGCTTGTTGCAGAAGGAAAACGCGGTGCTTTAGCAGCGAAAAAGGTAACAACAA
ATTTAGATGAATATTTATCTGCTTGTCAATTAGGTATTACAGTTACGGCTATGGGATTAGGTTGGTTAGGTGAACCGACA
ATTGAAAAGTTATTACACCCGTTATTTGAGAAATGGAACTTAAACCCTTCTATTTCATCAGTATTAACATTTGGTCTTGC
TTTTATGTTAATGACGTATTTACACGTTGTAGTAGGGGAATTAGCTCCGAAAACGATGGCAATTCAAAAGGCTGAAAGGG
TAACGTTATTATTGGCAGGTCCATTAATGATGTTCTATAAAGTAATGTATCCATTTATTTGGGTATTGAACGGTTCAGCG
CGTGTTGTAACTGGCTTATTCGGTTTAAAACCGGCTTCTGAACATGAAGTAGCTCATACAGAGGAAGAATTACGCCTTAT
CCTTTCAGATAGCTATGAAAGTGGCGAAATTAATCAGGCTGAATACAAGTATGTAAATAACATTTTTGAATTTGATAATC
GTATTGCAAAAGAGATTATGGTACCGCGAACAGAAATCGTTGGTTTCTACCTGGAAGATTCAGTAGAAGAACACATGAAA
GTAATCCAAAATGAGCGATACACACGTTATCCGATTTTTGGAGAAGATAAAGATGATATTATCGGTATGGTTAACGTAAA
AGATTTCTTTATTCGATATATGACCGAGGATCAAAAAGATTTATCATCCATTCGCTCGTATATGCGTCCGATTATTGAAG
TGATGGAAACAACTCCAATTCACGATTTATTACTTCAAATGCAGAAGAAGCGAATTCCGATGGCTGTTTTATATGATGAG
TACGGAGGAACAGCTGGAATTGTAACGCTTGAGGACATCTTGGAGGAAATCGTCGGCGAAATTCGTGATGAATATGATGA
AGATGAAGCACCACCAATTCAACATGTGAACGAGCAACATATCATTGTTGATGGAAAAGTGCTTATCTCAGAAGTGAAAG
ATTTATTTGGATTACACATTGAAGAAGATGATGTGGATACAATCGGTGGATGGATTATGATGCAAAATCACGAAATCGAA
GAAGGACAACACGTTGAGGCGGAAGGTTATGAATTTAAAGTGTTAGAAAAAGACGCTTACCAAATTAAACGTGTTGAAAT
TCGTAAGATGGAAGAGGAACAAGAAGAAGAAAAAGCAGCAACTGTGTAA

Upstream 100 bases:

>100_bases
CTTTAATTTTTGTATCGGGCTATGTTTTCTAAGAAACAAATAAGAAAACATTATAGTATACAGGAGGTGGACACCTTAGT
TTTTTAACTAAGGGGATTCA

Downstream 100 bases:

>100_bases
GTTGCTGCTTTTCTTCTAAAGTATAAAAAATGAGAAATTAGGAGCGGATATTTTGATTCAAGCAGCCTTACGTGTATATC
GATTACAATTGTATGTGATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAERVTLLLAGPLMMFYKVMYPFIWVLNGSA
RVVTGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV

Sequences:

>Translated_442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAERVTLLLAGPLMMFYKVMYPFIWVLNGSA
RVVTGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV
>Mature_442_residues
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPT
IEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAERVTLLLAGPLMMFYKVMYPFIWVLNGSA
RVVTGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDE
YGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIE
EGQHVEAEGYEFKVLEKDAYQIKRVEIRKMEEEQEEEKAATV

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=404, Percent_Identity=47.2772277227723, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1790664, Length=432, Percent_Identity=23.3796296296296, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI145693175, Length=426, Percent_Identity=25.3521126760563, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786879, Length=255, Percent_Identity=30.1960784313725, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082033, Length=270, Percent_Identity=25.1851851851852, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788119, Length=246, Percent_Identity=25.609756097561, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539402, Length=261, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50552; Mature: 50552

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHH
ACQLGITVTAMGLGWLGEPTIEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGE
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAPKTMAIQKAERVTLLLAGPLMMFYKVMYPFIWVLNGSARVVTGLFGLKPASEHEVAHT
HCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCHHCC
EEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPI
HHHCCCCEECCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
HDLLLQMQKKRIPMAVLYDEYGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQH
HHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCE
IIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIEEGQHVEAEGYEFKVLEKDAY
EEEEHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCHH
QIKRVEIRKMEEEQEEEKAATV
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHH
ACQLGITVTAMGLGWLGEPTIEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGE
HHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAPKTMAIQKAERVTLLLAGPLMMFYKVMYPFIWVLNGSARVVTGLFGLKPASEHEVAHT
HCCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCCHHCC
EEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPI
HHHCCCCEECCCCCCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCH
HDLLLQMQKKRIPMAVLYDEYGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQH
HHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCE
IIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIEEGQHVEAEGYEFKVLEKDAY
EEEEHHHHHHHHHHHHCCCCCCCCCHHCCCEEEEECCCCCCCCCCCCCCCEEEEECCCHH
QIKRVEIRKMEEEQEEEKAATV
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]