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The map label for this gene is npr [H]

Identifier: 52142150

GI number: 52142150

Start: 3220834

End: 3222531

Strand: Reverse

Name: npr [H]

Synonym: BCZK3091

Alternate gene names: 52142150

Gene position: 3222531-3220834 (Counterclockwise)

Preceding gene: 52142151

Following gene: 52142154

Centisome position: 60.79

GC content: 34.22

Gene sequence:

>1698_bases
ATGAAAAATTTCGTAAAAGTAGGTTTAACTACAGGAGTGGTGTTATCGGCGATTATGCCTTATGGAGGAGTACATGCGGC
AACAGAAGATTTAAAAGTGGAAACAAAAGAAGATACGTTCCGAACAGGTAATTTAACAGCACCTTCTCAAAAATCGGCAG
AAAATGTAGCAAAAGATGCGCTAAAAGGAAAAACAGAACAAGCATTATCATCAAAGCAAATTAACACGGAATCAAAAGTT
AATTATAATGTTACGCAAAGTCGTAAATCTTATGATGGTACTACATTGGTGCGTCTTCAACAAACATATGAAGGGCGTGA
TGTATACGGATATCAACTAACAGCACATATTAATGATGATGGTGTACTTACGAGTGTTTCGGGGGATAGTGCCCAAGATT
TACAACAACAAGAAGATTTGAAACAACCTATTACTCTATCAGAAGAGGATGCAAAGAAGCAGCTTTTTAAAATCTATGGG
GATAATCTCACATTTGTTGAAGAACCAGAAATTAAACAAGTGGTATATGTAGATGAAAATACAAATAAAGCTACAAACGC
ATATCAAATTACTTTTAGTGCATCTACACCTGAATATGTATCAGGTACGGTATTAATTGATGCATTTGTTGGGGATCTAT
TAAAAGAACTCGTTCAAAAATTGGGTATACAAGTAGATAGTAGTATTGTCCAATCTGCGACAGCAAATAAATCACAAGAT
CCTTCAAAATTAACAGGAACAGGAAAAGATGATTTAGGTATTAATCGTACGTTTGGAATTACACAGCGAAGTGATGGAAC
GTACACTCTTGCAGATTATTCTCGTGGTAAAGGAATTGAAACGTATACTGCGAATTATAAAGATTATAATAATTATAGAA
GAAATGTATGGGGTTATTTGGATGATTTAGTAACAAGTAATTCTACAAATTTTACAGATCCTAAAGCAGTTAGTGCACAT
TATTTAGCGACGAAAGTATATGATTTTTATCAAGAAAAATATAGTCGTAACAGCTTTGATAATAATGGACAAAAAGTAAT
TTCAGTCGTTCATGGCTGGAATACAAATGGTAAGAATATAGGAAATCCTAAGCAGTGGTTTAATGCATTTAGTAATGGGG
CTATGCTAGTATACGGAGATCCAATTGTTAGAGCATTTGATGTGGCAGGACATGAGTTTACACACGCGGTTACAAGAAAT
GAGTCTGGACTTGAGTACGCAGGAGAAGCTGGTGCCATTAATGAGGCTCTATCTGATATTTTAGGGGTAGCAGTTGAAAA
GTATGCCAATAACGGAAAGTTCAATTGGACAATGGGGGAACAATCAGGTCGTATATTTAGAGATATGAAAAACCCATCAT
CTATCTCTTCTAGATATCCAGAAGATTATAGACATTATAACAATTTACCTATTGATGCTGATCACGATTATGGTGGTGTA
CACACGAACTCTAGCATTATAAATAAAGTAGCTTATTTAATTGCTAGTGGTGGAAATCATAATGGAGTAAATGTACAAGG
CATTGGGGAAGATAAAATGTTTGATATTTTCTATTATGCAAATACGGATGAATTAAATATGACTTCTGATTTTAAAGAAT
TAAAAGAAGCTTGTATTCGTGTAGCAACGAATTTATATGGTAAAGACTCCTTAGAAGTACAGGCTGTTCAACAAGCATTT
AAAGCAGCTTATATTTAA

Upstream 100 bases:

>100_bases
TATGTAAAATCGATTGGCTATAGTTAAAAGGTTTATCTATGCTAAAAATTGTAAAATACATTTATTTAATTTAATAATAC
GATTATAAAGGAGTAAAAAT

Downstream 100 bases:

>100_bases
TACTATTGTGATGAATTGAAAACTCTCTTATTTTAATATAATGATTGATTTGTATATGTAGGCAAAAACCTTGTAGAATT
TTTCTGCAAGGTTTTTTAGA

Product: neutral protease (bacillolysin)

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MKNFVKVGLTTGVVLSAIMPYGGVHAATEDLKVETKEDTFRTGNLTAPSQKSAENVAKDALKGKTEQALSSKQINTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANKSQD
PSKLTGTGKDDLGINRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSLEVQAVQQAF
KAAYI

Sequences:

>Translated_565_residues
MKNFVKVGLTTGVVLSAIMPYGGVHAATEDLKVETKEDTFRTGNLTAPSQKSAENVAKDALKGKTEQALSSKQINTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANKSQD
PSKLTGTGKDDLGINRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSLEVQAVQQAF
KAAYI
>Mature_565_residues
MKNFVKVGLTTGVVLSAIMPYGGVHAATEDLKVETKEDTFRTGNLTAPSQKSAENVAKDALKGKTEQALSSKQINTESKV
NYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDDGVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYG
DNLTFVEEPEIKQVVYVDENTNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANKSQD
PSKLTGTGKDDLGINRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYLDDLVTSNSTNFTDPKAVSAH
YLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNIGNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRN
ESGLEYAGEAGAINEALSDILGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIRVATNLYGKDSLEVQAVQQAF
KAAYI

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 62565; Mature: 62565

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFVKVGLTTGVVLSAIMPYGGVHAATEDLKVETKEDTFRTGNLTAPSQKSAENVAKDA
CCCEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
LKGKTEQALSSKQINTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDD
HCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCC
GVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYGDNLTFVEEPEIKQVVYVDEN
CEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
TNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANKSQD
CCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
PSKLTGTGKDDLGINRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYL
CCCCCCCCCCCCCCCCEECCEECCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHH
DDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNI
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDI
CCHHHHHHHHCCCEEEEECCCHHEEHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCE
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIR
ECCHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
VATNLYGKDSLEVQAVQQAFKAAYI
HHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNFVKVGLTTGVVLSAIMPYGGVHAATEDLKVETKEDTFRTGNLTAPSQKSAENVAKDA
CCCEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCCCCCCHHHHHHHHHHH
LKGKTEQALSSKQINTESKVNYNVTQSRKSYDGTTLVRLQQTYEGRDVYGYQLTAHINDD
HCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEEEECCC
GVLTSVSGDSAQDLQQQEDLKQPITLSEEDAKKQLFKIYGDNLTFVEEPEIKQVVYVDEN
CEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
TNKATNAYQITFSASTPEYVSGTVLIDAFVGDLLKELVQKLGIQVDSSIVQSATANKSQD
CCCCCCEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
PSKLTGTGKDDLGINRTFGITQRSDGTYTLADYSRGKGIETYTANYKDYNNYRRNVWGYL
CCCCCCCCCCCCCCCCEECCEECCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHH
DDLVTSNSTNFTDPKAVSAHYLATKVYDFYQEKYSRNSFDNNGQKVISVVHGWNTNGKNI
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GNPKQWFNAFSNGAMLVYGDPIVRAFDVAGHEFTHAVTRNESGLEYAGEAGAINEALSDI
CCHHHHHHHHCCCEEEEECCCHHEEHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LGVAVEKYANNGKFNWTMGEQSGRIFRDMKNPSSISSRYPEDYRHYNNLPIDADHDYGGV
HHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCE
HTNSSIINKVAYLIASGGNHNGVNVQGIGEDKMFDIFYYANTDELNMTSDFKELKEACIR
ECCHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHH
VATNLYGKDSLEVQAVQQAFKAAYI
HHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]