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The map label for this gene is ribBA [H]

Identifier: 52142144

GI number: 52142144

Start: 3229127

End: 3229864

Strand: Reverse

Name: ribBA [H]

Synonym: BCZK3097

Alternate gene names: 52142144

Gene position: 3229864-3229127 (Counterclockwise)

Preceding gene: 52142142

Following gene: 52142146

Centisome position: 60.93

GC content: 33.6

Gene sequence:

>738_bases
ATGGTTACAACAGATACAATTCATATGTTAGAAGATAAAATTCAATTTATACATCAAGATAGAAAGGATATTTATTTAGT
AGGTCCTATCAAATTGCCAATTAATTTATATGGGGAGACTAAAGCTTTCCAATGGTATTCTTGGTTACAATGTAGTGAGG
GTACAAATAGTGTAGAAGGGATTATTGAAAAACTTTCATCTATTAATTTAGCTGATATGCAGCAATCTAGTGTGCTTGTA
TATGGTGATTTTGAGAATTCTGAAGATGCTCTAATTCGTATGCATAGTATTTGTCACACGGGTGATATTTTTGGTAGTAA
ACGTTGTGACTGTGGATTCCAATTAAAGCAGTCTTTACACATGATTACAGAACATGGTTCAGGTGCTTTATTTTACTTAG
CGAATCATGAAGGAAGAGGAATTGGCTTGTTTAGTAAAGCGATGACGTACCTCTTACAAGAAAATGGGTTAGATACAGTA
GAAGCTAATCTAAAACTAGGTTTTGAAGATGATGTTCGAAACTATGATGATACAATTGAAGTATTAAAAGCACTACGCTC
AAAACCTGTAAAACTTATTACAAATAATCCGAAAAAATTAGAAGCGTTACAAAAAGCTGGATTAAATGTTACGAGTCGTG
AACCGTTATGGGGTGATGTCTCAGAGTTTAATGAGAAATATTTGCAAACGAAGATTCAACGTTCTGGACATTTTGAAGGG
GGACACTTACATGCTTGA

Upstream 100 bases:

>100_bases
AATATCATCTGTAAAAACACTTACGTTGTGTAAGTTAAACAATAAAAAATATAACGATGGAAGAGGATTTTTAGAGATTC
TCTATACTAGGAGGTACCTA

Downstream 100 bases:

>100_bases
GCATGAATTGTATATGAAGTTAGCACTAGAAAATGCCAAGGCTATGAAGGGACAAACGACTCCAAATCCACTGGTTGGAT
CTGTAATTGTAAATGATAAC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MVTTDTIHMLEDKIQFIHQDRKDIYLVGPIKLPINLYGETKAFQWYSWLQCSEGTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLHMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLKLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA

Sequences:

>Translated_245_residues
MVTTDTIHMLEDKIQFIHQDRKDIYLVGPIKLPINLYGETKAFQWYSWLQCSEGTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLHMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLKLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA
>Mature_245_residues
MVTTDTIHMLEDKIQFIHQDRKDIYLVGPIKLPINLYGETKAFQWYSWLQCSEGTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLHMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLKLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=169, Percent_Identity=46.7455621301775, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=38.5964912280702, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 27697; Mature: 27697

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTDTIHMLEDKIQFIHQDRKDIYLVGPIKLPINLYGETKAFQWYSWLQCSEGTNSVEG
CCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCCHHHHHHHEEECCCCCHHHH
IIEKLSSINLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLH
HHHHHHCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLKLGFEDDVRNYDDTIE
HHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHCCHHHHHH
VLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GHLHA
CCCCC
>Mature Secondary Structure
MVTTDTIHMLEDKIQFIHQDRKDIYLVGPIKLPINLYGETKAFQWYSWLQCSEGTNSVEG
CCCCHHHHHHHHHHHHHHCCCCCEEEEECEEEEEEECCCCCHHHHHHHEEECCCCCHHHH
IIEKLSSINLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLH
HHHHHHCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLKLGFEDDVRNYDDTIE
HHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHCCHHHHHH
VLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GHLHA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA