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The map label for this gene is sqhC [H]

Identifier: 52141979

GI number: 52141979

Start: 3393211

End: 3395064

Strand: Reverse

Name: sqhC [H]

Synonym: BCZK3265

Alternate gene names: 52141979

Gene position: 3395064-3393211 (Counterclockwise)

Preceding gene: 52141977

Following gene: 52141978

Centisome position: 64.05

GC content: 37.65

Gene sequence:

>1854_bases
TTGTTATTATACGAAAAAGTGCATGAAGAAATAGTGAGAAGAGCAACTGCACTTCAAACGATGCAATGGCAAGATGGTAC
GTGGCGGTTTTGTTTTGAAGGAGCTCCATTAACAGATTGCCATATGATTTTTTTATTAAAATTATTAGGTAGAGAAAAAG
AGATAGAACCGTTTGTAGAAAGAATAGCATCACTCCAAACAAATGAAGGAACATGGAAATTGTATGAAGATGAAGTGGGA
GGTAATTTATCAGCTACCATTCAATCTTATGCCGCCTTACTCGCATCGAAAAAATATACAAAAGAAGATGCGAATATGAA
GCGAGCGGAAAATTTTATTAAGGAACGCGGAGGCGTGGCGCGTGCTCATTTTATGACGAAGTTTTTATTAGCAATTCATG
GAGGATATGAATATCCTTCACTCTTTCATTTACCAACACCAATTATGTTTCTGCAAAATGATTCCCCCCTCAGTATATTT
GAATTGAGTAGCTCAGCGCGTATTCATTTAATTCCGATGATGTTGTGTTTAAATAAGAGATTTCGAGTAGGGAAAAAGTT
ATTGCCAAATTTAAATCACATTGCAGGCGGGGGCGGAGAATGGTTTCGAGAAGATCGGTCTCCAGTTTTTCAAACGTTAA
TAAGTGATGTAAAACAAATTATATCGTATCCACTTTCGTTACATCATAAAGGATATGAGGAAATAGAACGTTTTATGAAA
GAGCGTATTGATGAAAATGGAACGTTATATAGTTACGCAACTGCCTCGTTTTATATGATTTATGCTTTACTCGCGTTAGG
ACATTCTCCTCAATCATCAATGATTCAAAAGGCTATAGCTGGGTTAACATCTTATATATGGAAGATGGGAAGAGGGAGTC
ATTTGCAAAACTCTCCTTCAACCGTGTGGGATACAGCTTTACTAAGCTATGCGTTACAAGAGGCCCGCGTTTCAAAGGAT
AATAAGATGATTCAAAATGCAACAGCGTATTTATTAAAAAAACAGCATACAAAAAAAGCTGATTGGAGCGTACATGCTCC
GGCGCTTATTCCTGGCGGTTGGGGTTTTTCAGATGTGAATACGACAATTCCAGATATAGATGATACAACAGCTGTGCTAA
GGGCATTGGCACGAAGTAGAGGAAACAAAAATATAGATAATGCTTGGCAGAAAGGAGTCAATTGGATTAAAGGATTACAA
AATAATGATGGGGGCTGGGGAGCTTTTGAAAAAGGTGTGACGAGCAAATTATTAGCAAATTTACCAATCGAAAATGCAAG
TGATATGATTACAGATCCTTCTACACCAGATATTACAGGGAGAGTGTTAGAGTTTTTCGGGACGTATGCACAAAACGGAT
TGCCTGAGAAACAAAAACAAAGTGCGATAAATTGGTTAATGAATGCACAAGAGGAAAATGGATCATGGTATGGGAAATGG
GGGATTTGTTATATATATGGTACGTGGGCTGTTATGACAGGTTTACGGTCACTCGGAATTCCGTCTAGCAATCCATCATT
GAAACGAGCAGCTTCATGGCTTGAATATATACAGCATGAAGATGGTGGTTGGGGAGAATCATGCCACAGTAGTGTGGAGA
AAAGGTTCGTTACTTTACCATTTAGTACACCATCCCAAACTGCATGGGCGTTAGATGCTCTCATTTCTTACTATGATACA
GAAACGCCAGCTATTCGAAAAGGTGTTTCATATTTGCTTTCGAATCCTTATGTGAATGAAAGATATCCTACTGGAACAGG
TTTACCAGGTGCGTTTTATATTAGATATCATAGCTATGCCCATATATATCCACTACTTACTTTAGCACATTATTTAAAAA
AATATAGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAACATTTTATATGTTCTGCTTTTCTTTGTATTCATACATATTCAGCTACTTTCTTGAATATCGTTATACGGATTT
CAAAAGGGTGGGTGAATAAC

Downstream 100 bases:

>100_bases
ACCGAGAGATATCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTGTTGAAAAGAATAAGGTTGTGCTTCCTTATTTTTC
TGTTGACTGGCGTTTTTGAC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MLLYEKVHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGREKEIEPFVERIASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAIHGGYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLISDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSPQSSMIQKAIAGLTSYIWKMGRGSHLQNSPSTVWDTALLSYALQEARVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALIPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWQKGVNWIKGLQ
NNDGGWGAFEKGVTSKLLANLPIENASDMITDPSTPDITGRVLEFFGTYAQNGLPEKQKQSAINWLMNAQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEYIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK

Sequences:

>Translated_617_residues
MLLYEKVHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGREKEIEPFVERIASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAIHGGYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLISDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSPQSSMIQKAIAGLTSYIWKMGRGSHLQNSPSTVWDTALLSYALQEARVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALIPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWQKGVNWIKGLQ
NNDGGWGAFEKGVTSKLLANLPIENASDMITDPSTPDITGRVLEFFGTYAQNGLPEKQKQSAINWLMNAQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEYIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK
>Mature_617_residues
MLLYEKVHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGREKEIEPFVERIASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAIHGGYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLISDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSPQSSMIQKAIAGLTSYIWKMGRGSHLQNSPSTVWDTALLSYALQEARVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALIPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWQKGVNWIKGLQ
NNDGGWGAFEKGVTSKLLANLPIENASDMITDPSTPDITGRVLEFFGTYAQNGLPEKQKQSAINWLMNAQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEYIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=626, Percent_Identity=23.1629392971246, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI47933397, Length=626, Percent_Identity=23.1629392971246, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI224177558, Length=626, Percent_Identity=23.1629392971246, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI224177556, Length=563, Percent_Identity=22.9129662522202, Blast_Score=117, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321863, Length=288, Percent_Identity=26.7361111111111, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69757; Mature: 69757

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEKVHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGREKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RIASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIKERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGGYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLISDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSPQSSMIQKAIAGLTSYIWKMGRGSHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TVWDTALLSYALQEARVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALIPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCEEECCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWQKGVNWIKGLQNNDGGWGAFEKGVTSKLLAN
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNGLPEKQKQSAINWLMNAQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEECC
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEYIQHEDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYLKKYRK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYEKVHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGREKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RIASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIKERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGGYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLISDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSPQSSMIQKAIAGLTSYIWKMGRGSHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TVWDTALLSYALQEARVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALIPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCEEECCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWQKGVNWIKGLQNNDGGWGAFEKGVTSKLLAN
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNGLPEKQKQSAINWLMNAQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEECC
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEYIQHEDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYLKKYRK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]