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The map label for this gene is moeA [H]

Identifier: 52141971

GI number: 52141971

Start: 3399752

End: 3401059

Strand: Reverse

Name: moeA [H]

Synonym: BCZK3274

Alternate gene names: 52141971

Gene position: 3401059-3399752 (Counterclockwise)

Preceding gene: 52141968

Following gene: 52141970

Centisome position: 64.16

GC content: 39.07

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAATTAATGGAATTTGCTAATGAGGGTTTAAAGGAGCT
ACTACCTATTGAATTAGCTTACGGACGTGTATTAGCGGAGGATTTAGTAGCTGACCATGACGTACCTTCATTCAATCGTT
CCCCGTATGACGGATTTGCTATTAGAGCAGAAGATACGAATTTAGCAAGTTATGAAACGCCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCGATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGGAGCACAGAT
TCCGAGTGGATGTGATGCAGTTGTTATGCTAGAGCTGGCTCGCCAATATGAGGAGGCTGGCAGTAAGTATATGGAATTGA
AACGGTCATTCAAAGCGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCAAAGAAAGGA
ACATACATTAATCCAGGTATTTTAGCTCTTCTTGCTACGTTCGGGTATAGCGAGGTGCCAGTTGCGAGAAAGCCTGTAGT
TGGACTATTAGCGACTGGCAGTGAATTACTAGATGTAAACGATTCATTACAGCCAGGGAAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTTCATACGTGT
TTTACGGCTGTAAAAGAAGCGTTAGGCAAAGTAGATATGTTAATTACAACGGGCGGTGTATCCGTAGGAGATTACGATTA
TTTACCAGCTATTTATGAAAAGTTAGGTGCTTCTGTTCTTTTTAATAAAGTTGCAATGCGGCCAGGAAGTGTAACGACTG
TAGCGCAATTAAATGGCAAGTTATTATTTGGTTTATCAGGAAATCCATCTGCTTGTTACGTAGGGTTTGAATTGTTTGTA
AGACCTTGTATTCGGACGTATATGTTTAGTCAAAAAGCACATGTAAAAAGAGAAAAAGCATTATTAGGAGAAGACTTTTT
AAAGCCAAATCCATTTACAAGGTTTGTACGAGGAAAACTAACATATAACGAAGGGCAGTTAATCGCTTATCCGTCAGGGT
TTGATAAATCTAGCTCAGTTTCTTCTCTAGCAGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGAGGGTATAAA
AAAGATATGTTCGTAGATATTCTCTTGTTGGAAGATAACGAAGGTAGTGAATGGCCTTGGACATTTTATAAAGTGAGAGG
TGATTCTAATGGGACAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
TTTTCGAGATGGTCGTGTTTTCATTCATGGTACAAATGATATTTCAAAAGCGAAACAGTTATATTATCGCGTATTCGGTT
AATAGAAAGGGTTGTCAATA

Downstream 100 bases:

>100_bases
AATTGTAGATAGACTGATTGTAGTTGAAGAAGTAACGAATAAGGTTGCAAGAAGAGAAGCAGGTGCGATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKLMEFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELARQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGILALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALGKVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSQKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDILLLEDNEGSEWPWTFYKVRGDSNGTSAI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKLMEFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELARQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGILALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALGKVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSQKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDILLLEDNEGSEWPWTFYKVRGDSNGTSAI
>Mature_435_residues
MERRVPITVEEAVRKLMEFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELARQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGILALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALGKVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSQKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDILLLEDNEGSEWPWTFYKVRGDSNGTSAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=34.9489795918367, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI10880983, Length=391, Percent_Identity=35.0383631713555, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=34.5945945945946, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=398, Percent_Identity=28.894472361809, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=391, Percent_Identity=27.1099744245524, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136978, Length=366, Percent_Identity=28.6885245901639, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=366, Percent_Identity=28.6885245901639, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47783; Mature: 47783

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKLMEFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELA
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCHHHHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGILALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALGKVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSQKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDILLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKLMEFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFDEKVGPFQAVRIMTGAQIPSGCDAVVMLELA
EEECCCCCCCCCCCCCEEEHHCCCCCCCCHHCCCCHHEEEEEECCCCCCCCCHHHHHHHH
RQYEEAGSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGILALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALGKVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSQKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDILLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]