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The map label for this gene is mmgA [H]

Identifier: 52141915

GI number: 52141915

Start: 3462270

End: 3463361

Strand: Reverse

Name: mmgA [H]

Synonym: BCZK3329

Alternate gene names: 52141915

Gene position: 3463361-3462270 (Counterclockwise)

Preceding gene: 52141914

Following gene: 52141916

Centisome position: 65.34

GC content: 41.67

Gene sequence:

>1092_bases
ATGAATAGAGCAGTTATTGTAGAAGCGAAAAGGACACCTATTGGTAAGAAGAATGGGATGTTAAAAGACTATGAAGTTCA
GCAATTAGCAGCACCGCTTCTTACATTTTTAAGTAAAGGAATGGAGAGAGCGATAGACGATGTCATATTAGGGAATGTTG
TTGGGCCAGGAGGGAATGTTGCGAGATTATCTGCTTTAGAAGCAGGGCTTAGTCATCATATTCCGGGTGTAACGATTGAC
CGGCAATGTGGTGCCGGATTGGAAGCGATTCGCACCGCGTGTCATTTCATTCAAGGCGGGGCCGGTAAGTGTTATATCGC
CGGAGGAGTAGAGAGTACAAGTATGTCACCTTTTCAAAATAGAGCACGATTTTCACCAGAAACAATAGGCGATCCTAATA
TGGGAGTAGCGGCTGAATATGTTGCAGAAAGTTATAACATCACGAGAGAAATGCAAGACGAGTATGCATGCCTCAGTTAT
AAACGAACACTGCAAGCATTAGCAAAAGGATATATACATGAGGAAATATTGTCTTTTAATGGATTGCTAGATGAATCCAT
TAAGCCAGAAATGAATTATGAACGAATCATTAAAAGAACAAAACCTGCATTTTTACACAATGGTACAGTAACGGCAGGTA
ATTCGTGCGGTGTAAATGATGGAGCATGTACCGTTCTTGTAATGGAAGAGGGACAAGCCCGAAAATTAGGATACAAGCCT
GTACTTCGTTTCGTTCGTAGTGTTGTAGTTGGAGTGGATCCCAACCTTCCGGGGACTGGTCCGATATTTGCGTTGAACAA
ATTATTAGACGAAATGAATATGAAAGTAGAGGACATCGATTATTTTGAAATAAACGAAGCGTTCGCTTCAAAAGTTGTAG
CTTGTGCAAAGGAATTACAAATTCCGTATGAAAAATTAAATGTAAATGGTGGTGCAATTGCGCTCGGTCATCCGTACGGT
GCATCTGGGGCTATGCTTATAACGCGCTTGTTTTATCAGGCGAAACGAGAGCGTATGAAATACGGAATCGCGACGTTAGG
AATAGGGGGCGGGATAGGTCTTGCACTATTATTTGAGAAAGTAGAAGACTAG

Upstream 100 bases:

>100_bases
CCGAAAGAATGGTATTTTGTAGATGAAATACCGTATACAAATAGCGGGAAAATCGCTCGTATGGAAGCGAAAAGTATCAT
TGAAAATCAGGAGAAAATAT

Downstream 100 bases:

>100_bases
AAAGGAACTAGTTTTCTACTTTCTGAGGAACATAAGCATTGCTACCAGGTTTTGCTTTTATTTCATTCCAAGCAGCGATA
GCATCAGCTTTTGATTTTCC

Product: acetyl-CoA acetyltransferase

Products: CoA; acetoacetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLSHHIPGVTID
RQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSMSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACTVLVMEEGQARKLGYKP
VLRFVRSVVVGVDPNLPGTGPIFALNKLLDEMNMKVEDIDYFEINEAFASKVVACAKELQIPYEKLNVNGGAIALGHPYG
ASGAMLITRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED

Sequences:

>Translated_363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLSHHIPGVTID
RQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSMSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACTVLVMEEGQARKLGYKP
VLRFVRSVVVGVDPNLPGTGPIFALNKLLDEMNMKVEDIDYFEINEAFASKVVACAKELQIPYEKLNVNGGAIALGHPYG
ASGAMLITRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED
>Mature_363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLSHHIPGVTID
RQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSMSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACTVLVMEEGQARKLGYKP
VLRFVRSVVVGVDPNLPGTGPIFALNKLLDEMNMKVEDIDYFEINEAFASKVVACAKELQIPYEKLNVNGGAIALGHPYG
ASGAMLITRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED

Specific function: May be involved in fatty acid metabolism [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=35.969387755102, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=33.3333333333333, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4501853, Length=384, Percent_Identity=34.8958333333333, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=32.2335025380711, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI4504327, Length=419, Percent_Identity=29.5942720763723, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI194353979, Length=364, Percent_Identity=28.2967032967033, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=37.3711340206186, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=38.0597014925373, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=38.6934673366834, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=36.5239294710327, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=27.6029055690073, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=37.2448979591837, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=31.7948717948718, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=29.9528301886792, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=30.4123711340206, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=26.6149870801034, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=34.3669250645995, Blast_Score=185, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=31.9201995012469, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=37.7833753148615, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=36.9230769230769, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=32.1428571428571, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI17137578, Length=420, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.9

Molecular weight: Translated: 39270; Mature: 39270

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00737 THIOLASE_2 ; PS00139 THIOL_PROTEASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNV
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSMSPFQN
HHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHH
RARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSYKRTLQALAKGYIHEEILSFN
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACTVLVMEEGQARKLGYKP
CCCCCCCCCCCCHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEECCCCCCCCCHHH
VLRFVRSVVVGVDPNLPGTGPIFALNKLLDEMNMKVEDIDYFEINEAFASKVVACAKELQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHC
IPYEKLNVNGGAIALGHPYGASGAMLITRLFYQAKRERMKYGIATLGIGGGIGLALLFEK
CCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHH
VED
HCC
>Mature Secondary Structure
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNV
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
ARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSMSPFQN
HHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHH
RARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSYKRTLQALAKGYIHEEILSFN
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACTVLVMEEGQARKLGYKP
CCCCCCCCCCCCHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEECCCCCCCCCHHH
VLRFVRSVVVGVDPNLPGTGPIFALNKLLDEMNMKVEDIDYFEINEAFASKVVACAKELQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHC
IPYEKLNVNGGAIALGHPYGASGAMLITRLFYQAKRERMKYGIATLGIGGGIGLALLFEK
CCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHH
VED
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA

Specific reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]