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The map label for this gene is thyX [H]

Identifier: 52141802

GI number: 52141802

Start: 3576283

End: 3577044

Strand: Reverse

Name: thyX [H]

Synonym: BCZK3445

Alternate gene names: 52141802

Gene position: 3577044-3576283 (Counterclockwise)

Preceding gene: 52141800

Following gene: 52141804

Centisome position: 67.48

GC content: 39.24

Gene sequence:

>762_bases
ATGGAGAATTTAAATATGGATGTAAAGTTACTAGCACATACGCAATTATCTGAGGAGTTTGTTAATTATTTATCGCTTGT
ATCTGGTATTGGAGAGGAAGGATTTGATCCTACCCATGGGCAAGTGATAGCTTTATCAGCAATCCGTACGTGCTACTCGC
CAAATAGACCTAGTAGGATTGCGACTTTAGAGGGAGAGAAGTACTTCAAAGGAAAAGCAACTGATGGAAAAGGTGGAAAA
GAAGTAGATCGGCTCATTAGACATATTGTGGGTTCAGGGCATACTTCAACACTAGAGCATCTAACATATACCTTTGCAGT
AGAAGGAGTTAGTAGAGCATTACTCACTCAGTTAACACGTCATCGTGTAGGATTCAGTTACTCAGTTCAATCTCAAAGAT
ATGTACGCATGGGAAGTAATGATAAGATAGGTGGCTTTGATTACGTAGTGCCCGAAACTGTTAAAGCTAAAGGAGAACAT
GTTGTTAAAGCTTACAACGAAATGATGTACAAACTACAAAGTGATTATGATCTGCTTAGAACATTAGGAATTCCTGCTGA
GGATGCTCGTAGTGTACTGCCAAACGCGGTTACAACTAATCTAGTATTAACAGTCAATTTACGGGGGCTTTTAGATTTCT
ACAATAAACGTAGAAAAGGGAAAGGTGCTCAAGCTGAAATCGCAGAGTTGGCAGAACAATTAAGGCAAGAAGTTGTCAAA
GTTGAAAAGTGGGTAGACGAGTTTTTCGGAAGTGGAAAGTAA

Upstream 100 bases:

>100_bases
TTACCTATGAGGATGTTATTGATTCGTATAAGGAAAAGAATGCGGAAAACTTTGAGAGACAGAATAGCGGATATTAATCA
AATTTTAGTTTTATTAAGAA

Downstream 100 bases:

>100_bases
CAGAAGCCTAACAAGGTTACAAATAAAAGAGCAGCTAGCAAAAGCTAACTGCTCATCTCCAGGGGAATTGGAGACTGGTG
TATCTGTAGTATTGGCGGAA

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPTHGQVIALSAIRTCYSPNRPSRIATLEGEKYFKGKATDGKGGK
EVDRLIRHIVGSGHTSTLEHLTYTFAVEGVSRALLTQLTRHRVGFSYSVQSQRYVRMGSNDKIGGFDYVVPETVKAKGEH
VVKAYNEMMYKLQSDYDLLRTLGIPAEDARSVLPNAVTTNLVLTVNLRGLLDFYNKRRKGKGAQAEIAELAEQLRQEVVK
VEKWVDEFFGSGK

Sequences:

>Translated_253_residues
MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPTHGQVIALSAIRTCYSPNRPSRIATLEGEKYFKGKATDGKGGK
EVDRLIRHIVGSGHTSTLEHLTYTFAVEGVSRALLTQLTRHRVGFSYSVQSQRYVRMGSNDKIGGFDYVVPETVKAKGEH
VVKAYNEMMYKLQSDYDLLRTLGIPAEDARSVLPNAVTTNLVLTVNLRGLLDFYNKRRKGKGAQAEIAELAEQLRQEVVK
VEKWVDEFFGSGK
>Mature_253_residues
MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPTHGQVIALSAIRTCYSPNRPSRIATLEGEKYFKGKATDGKGGK
EVDRLIRHIVGSGHTSTLEHLTYTFAVEGVSRALLTQLTRHRVGFSYSVQSQRYVRMGSNDKIGGFDYVVPETVKAKGEH
VVKAYNEMMYKLQSDYDLLRTLGIPAEDARSVLPNAVTTNLVLTVNLRGLLDFYNKRRKGKGAQAEIAELAEQLRQEVVK
VEKWVDEFFGSGK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 28247; Mature: 28247

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPTHGQVIALSAIRTCYSPNRPSRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCEE
ATLEGEKYFKGKATDGKGGKEVDRLIRHIVGSGHTSTLEHLTYTFAVEGVSRALLTQLTR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HRVGFSYSVQSQRYVRMGSNDKIGGFDYVVPETVKAKGEHVVKAYNEMMYKLQSDYDLLR
HHCCCEEECCCCHHEECCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TLGIPAEDARSVLPNAVTTNLVLTVNLRGLLDFYNKRRKGKGAQAEIAELAEQLRQEVVK
HCCCCHHHHHHHCCCHHHCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VEKWVDEFFGSGK
HHHHHHHHHCCCC
>Mature Secondary Structure
MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPTHGQVIALSAIRTCYSPNRPSRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCCCCCEE
ATLEGEKYFKGKATDGKGGKEVDRLIRHIVGSGHTSTLEHLTYTFAVEGVSRALLTQLTR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HRVGFSYSVQSQRYVRMGSNDKIGGFDYVVPETVKAKGEHVVKAYNEMMYKLQSDYDLLR
HHCCCEEECCCCHHEECCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
TLGIPAEDARSVLPNAVTTNLVLTVNLRGLLDFYNKRRKGKGAQAEIAELAEQLRQEVVK
HCCCCHHHHHHHCCCHHHCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VEKWVDEFFGSGK
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]