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The map label for this gene is pyrE [H]

Identifier: 52141607

GI number: 52141607

Start: 3779903

End: 3780535

Strand: Reverse

Name: pyrE [H]

Synonym: BCZK3641

Alternate gene names: 52141607

Gene position: 3780535-3779903 (Counterclockwise)

Preceding gene: 52141605

Following gene: 52141609

Centisome position: 71.32

GC content: 39.18

Gene sequence:

>633_bases
ATGAAAAAAGAAATCGCATCGCATTTATTAGAAATTGGAGCAGTATTTTTACAACCAAATGATCCATTCACATGGTCTTC
AGGTATGAAATCACCAATTTATTGTGATAACCGTTTAACTTTATCTTATCCGAAAGTACGTCAAGCAATTGCAGCTGGAT
TAGAAGAGTTAATTAAAGAGCACTTCCCAACTGTAGAAGTTATTGCAGGAACAGCAACTGCTGGTATTGCGCACGCTGCA
TGGGTAAGCGATCGTATGGATTTACCAATGTGCTACGTACGTAGTAAAGCAAAAGGTCATGGTAAAGGGAACCAAATTGA
AGGAAAAGCTGAAAAAGGTCAAAAAGTAATAGTAGTAGAAGACTTAATTTCAACTGGCGGTAGTGCTATTACATGTGTAG
AAGCACTTCGCGAAGCTGGCTGTGAAGTATTAGGAATCGTATCAATCTTCACATACGAGCTAGAAGCAGGAAAAGAAAAG
CTAGAAGCAGCTAACGTAGCATCATACTCTTTAAGCGACTACAGTGCATTAACTGAAGTAGCAGCAGAAAAAGGTATGAT
CGGACAAGCTGAAACGAAAAAATTACAAGAGTGGCGTAAAAATCCAGCTGACGAAGCTTGGATCACAGCGTAA

Upstream 100 bases:

>100_bases
TTGGCTCAAGCTATATCGTAGTTGGACGTAGTATTACAAAAGCAGAAAATCCGCTTGAAGCGTATAAAACAGTAAAACAA
CAGTGGGAAGGTGTAACAGT

Downstream 100 bases:

>100_bases
CACGAAAAAAGACGACTGCGGGGGAACGCGGTCGTCTTTTTTATATCATTGTTAAAACTTCATGTGAAGTTCCATCAATA
TCAAAGAAAATCATATGACA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVIVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA

Sequences:

>Translated_210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVIVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA
>Mature_210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVIVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LEAANVASYSLSDYSALTEVAAEKGMIGQAETKKLQEWRKNPADEAWITA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=170, Percent_Identity=25.8823529411765, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=180, Percent_Identity=30, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=170, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=27.5510204081633, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22716; Mature: 22716

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKE
CHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHH
HFPTVEVIAGTATAGIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVIVVE
HCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHCCCCEEEEEH
DLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLEAANVASYSLSDYSALTEV
HHHHCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AAEKGMIGQAETKKLQEWRKNPADEAWITA
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKE
CHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHH
HFPTVEVIAGTATAGIAHAAWVSDRMDLPMCYVRSKAKGHGKGNQIEGKAEKGQKVIVVE
HCCCEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCHHCCCCEEEEEH
DLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLEAANVASYSLSDYSALTEV
HHHHCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AAEKGMIGQAETKKLQEWRKNPADEAWITA
HHHCCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA